CAMK2A (NM_171825) Human Untagged Clone

CAT#: SC109000

CAMK2A (untagged)-Human calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2


  "NM_171825" in other vectors (7)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CAMK2A
Synonyms CAMKA; CaMKIINalpha; MRD53; MRT63
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109000 sequence for NM_171825 edited (data generated by NextGen Sequencing)
ATGGCCACCATCACCTGCACCCGCTTCACGGAAGAGTACCAGCTCTTCGAGGAATTGGGC
AAGGGAGCCTTCTCGGTGGTGCGAAGGTGTGTGAAGGTGCTGGCTGGCCAGGAGTATGCT
GCCAAGATCATCAACACAAAGAAGCTGTCAGCCAGAGACCATCAGAAGCTGGAGCGTGAA
GCCCGCATCTGCCGCCTGCTGAAGCACCCCAACATCGTCCGACTACATGACAGCATCTCA
GAGGAGGGACACCACTACCTGATCTTCGACCTGGTCACTGGTGGGGAACTGTTTGAAGAT
ATCGTGGCCCGGGAGTATTACAGTGAGGCGGATGCCAGTCACTGTATCCAGCAGATCCTG
GAGGCTGTGCTGCACTGCCACCAGATGGGGGTGGTGCACCGGGACCTGAAGCCTGAGAAT
CTGTTGCTGGCCTCCAAGCTCAAGGGTGCCGCAGTGAAGCTGGCAGACTTTGGCCTGGCC
ATAGAGGTGGAGGGGGAGCAGCAGGCATGGTTTGGGTTTGCAGGGACTCCTGGATATCTC
TCCCCAGAAGTGCTGCGGAAGGACCCGTACGGGAAGCCTGTGGACCTGTGGGCTTGTGGG
GTCATCCTGTACATCCTGCTGGTTGGGTACCCCCCGTTCTGGGATGAGGACCAGCACCGC
CTGTACCAGCAGATCAAAGCCGGCGCCTATGATTTCCCATCGCCGGAATGGGACACTGTC
ACCCCGGAAGCCAAGGATCTGATCAATAAGATGCTGACCATTAACCCATCCAAACGCATC
ACAGCTGCCGAAGCCCTTAAGCACCCCTGGATCTCGCACCGCTCCACCGTGGCATCCTGC
ATGCACAGACAGGAGACCGTGGACTGCCTGAAGAAGTTCAATGCCAGGAGGAAACTGAAG
GGAGCCATTCTCACCACGATGCTGGCCACCAGGAACTTCTCCGGAGGGAAGAGTGGGGGA
AACAAGAAGAGCGATGGTGTGAAGGAATCCTCAGAGAGCACCAACACCACCATCGAGGAT
GAAGACACCAAAGTGCGGAAACAGGAAATTATAAAAGTGACAGAGCAGCTGATTGAAGCC
ATAAGCAATGGAGATTTTGAGTCCTACACGAAGATGTGCGACCCTGGCATGACAGCCTTC
GAACCTGAGGCCCTGGGGAACCTGGTTGAGGGCCTGGACTTCCATCGATTCTATTTTGAA
AACCTGTGGTCCCGGAACAGCAAGCCCGTGCACACCACCATCCTGAATCCCCACATCCAC
CTGATGGGCGACGAGTCAGCCTGCATCGCCTACATCCGCATCACGCAGTACCTGGACGCT
GGCGGCATCCCACGCACCGCCCAGTCGGAGGAGACCCGTGTCTGGCACCGCCGGGATGGC
AAATGGCAGATCGTCCACTTCCACAGATCTGGGGCGCCCTCCGTCCTGCCCCACTGA

Clone variation with respect to NM_171825.2
>OriGene 5' read for NM_171825 unedited
GGGGTGGGGGTTAAATAATANAATATAAANNNTTTCTTTCCCCCGCCCGTTGCCGCATTG
GGCGGTAGGCGTGTACGGTGGNGAGTCTATATAAGCAGAGCTCATTTAGGTGACACTATA
GAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGGTCAGTCAAA
CCGGTTCTCTGTTTGCACTCGGCAGCACGGGCAGGCAAGTGGTCCCTAGGTTCGGGAGCA
GAGCAGCAGCGCCTCAGTCCTGGTCCCCCAGTCCCAAGCCTCACCTGCCTGCCCAGCGCC
AGGATGGCCACCATCACCTGCACCCGCTTCACGGAAGAGTACCAGCTCTTCGAGGAATTG
GGCAAGGGAGCCTTCTCGGTGGTGCGAAGGTGTGTGAAGGTGCTGGCTGGCCAGGAGTAT
GCTGCCAAGATCATCAACACAAAGAAGCTGTCAGCCAGAGACCATCAGAAGCTGGAGCGT
GAAGCCCGCATCTGCCGCCTGCTGAAGCACCCCAACATCGTCCGACTACATGACAGCATC
TCAGAGGAGGGACACCACTACCTGATCTTCGACCTGGTCACTGGTGGGGAACTGTTTGAA
GATATCGTGGCCCGGGAGTATTACAGTGAGGCGGATGCCAGTCACTGTATCCAGCAGATC
CTGGAGGCTGTGCTGCACTGCCACCAGATGGGGGTGGTGCACCGGGACCTGAAGCCTGAG
AATCTGTTGCTGGCCTCCAAGCTCAAGGGTGCCGCAGTGAAGCTGGCAGACTTTGGCCTG
GCCATAGAGGTGGAGGGGGAGCACCAGGCATGTTTTGGGTTTGCAGGGACTCCTGGATAT
CTCTCCCCAAAGTGCTGCGGAAGGACCCGTACGGAAGCCTGTGGACCTGTGGCCTTGTGG
GGTCATCCTGTCATCCTGCCTGTTGGGTCCCCCCCGTCTGGGATAG
>OriGene 3' read for NM_171825 unedited
AACCCTAGGGATGGAAACTCCCCATTCCAGTATAGCACTGGGGNAGGGTCACAGGGCTGC
CACCCGGGTTCTGTTCAGAAAAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCACAAAAGTTTGTAGCTTTTTATTGCACT
GAAAACACCAAGAATAAAACAAACGCCCCTTTTTTTTATTCCACCCCCCCCCCAATAGCA
AAAAGTTTGAGCAGTGTTCATTCAAGTTCACAGCCACCTTTTTTTAAAAAAGAAAAGAAA
AAAAAAAAAGAACTTAAACAAAACCCCAAACAAATTGTAACAAAGAAACCAGCACGGGGA
GTCTGGCAAACTCATCCCCCAAAAGGGTCTCCCTTTGAAGGGAGACAGGAGGCCTTGGGT
CAGGATTCGCACCATGGTGGGCACAAACCCAGGAAAACACTTTCCTGTAAACGTGTTTTC
ATGCTGGAGCCAAGGTTTTGACTTGGGGTNGGATTTTTATTTATTTATTTATTATTATTA
TTATTATTTCGCAACCAAAGGATGTTTTGGAAGAACACAAATTTTGTCTGGGGAGGGTAG
GCTCTGGGCAAATTTTTCTGTGAATCTCCCCTGCCTGGCGCATTAAGATCATCCCTGGTG
CCCTGTGGTGGCACCAGGTGGCCTGCCCACCCACAGCGGTGCCCTTCACATGGGGGCCAT
TTTAGCCGTGGGGGAAAGATTTGGCTCCACTTTTCTGGCACTTTGGAGATGGACCATTGG
ACAAGGAGTGTTGTTAACCCAATGAAGGGAAGGACCTCGAGCTCCTTCCACTTTATTTCC
TTTGGGGGGGGAAAACCAAACCCCAAAAAGGGGAAGGGAATTGCG
Restriction Sites NotI-NotI     
ACCN NM_171825
Insert Size 4700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_171825.1, NP_741960.1
RefSeq Size 4803 bp
RefSeq ORF 1437 bp
Locus ID 815
Cytogenetics 5q32
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Calcium signaling pathway, ErbB signaling pathway, Glioma, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Wnt signaling pathway
Gene Summary 'The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]'
Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 4 both encode the same isoform (2). Isoforms 2 and 5 are the same length but differ in sequence. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

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