PLA2G12A (NM_030821) Human Untagged Clone

CAT#: SC109014

PLA2G12A (untagged)-Human phospholipase A2, group XIIA (PLA2G12A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PLA2G12A
• Synonyms: GXII; PLA2G12; ROSSY
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109014 sequence for NM_030821 edited (data generated by NextGen Sequencing)
  ATGGCCCTGCTCTCGCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGTC
  AGGTGCCAGGAGCAGGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAAC
  GGCGTTCATAAGATAGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGAC
  GGTCTCTGCCAGTATAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAA
  CCCTCCCCACCGAATGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATC
  CCTTCCCTGACAAAGTGTTGCAACCAACACGACAGGTGCTATGAAACCTGTGGCAAAAGC
  AAGAATGACTGTGATGAAGAATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAG
  AAAACACTAGGACTAACTCAGCATGTTCAGGCATGTGAAACAACAGTGGAGCTCTTGTTT
  GACAGTGTTATACATTTAGGTTGTAAACCATATCTGGACAGCCAACGAGCTGCATGCAGG
  TGTCATTATGAAGAAAAAACTGATCTTTAA
  
  Clone variation with respect to NM_030821.4
  345 g=>a;531 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_030821 unedited
  TATACGACTCACTATAGGGCGGCCGCGAATCGGCACGAGGGCTGGCCCAGGTGAGCGGGC
  GCGCTGGTCCAGGTGAGCGGGCGCGTCCCCGCGACGGCGCTGCCTTCCCGAGGCGGTTCA
  CGTAAAGACAGCGAGATCCTGAGGGCCAGCCGGGAAGGAGGCGTGGATATGGAGCTGGCT
  GCTGCCAAGTCCGGGGCCCGCGCCGCTGCCTAGCGCGTCCTGGGGACTCTGTGGGGACGC
  GCCCCGCGCCGCGGCTCGGGGACCCGTAGAGCCCGGCGCTGCGCGCATGGCCCTGCTCTC
  GCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGTCAGGTGCCAGGAGCA
  GGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAACGGCGTTCATAAGAT
  AGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGACGGTCTCTGCCAGTA
  TAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAACCCTCCCCACCGAA
  TGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATCCCTTCCCTGACAAA
  GTGTTGCAACCAACACGACAGGTGCTATGAAACCTGTGGCAAAAGCAAGATGACTGTGAT
  GAAGAATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAGAAACACTANGACTAA
  CTCAGCATGTTCAGGCATGTGAAACACAGTGGAGCTCTTGTTTGACAGTGTTATCATTTT
  AGGGNTGTAACCATATCTGGACAGNCAACGAGCTGATGGCAGGTGTCATTATGAGAAAAA
  ACTGATCTTTAAGGAGATGCGACAGCTAGTGACAGATGAGATAGGAGAACATAACTTGGA
  CAAAACCTATGGTTTTACACTAAACTGTCTAATTTTGGGAAGGATATTTTGAACA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_030821
• ORF Size: 570 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_030821.3, NP_110448.2
• RefSeq Size: 1699
• RefSeq ORF: 570
• Locus ID: 81579
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway
• Gene Summary: Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]). [supplied by OMIM, Mar 2008]