p38 (CRK) (NM_005206) Human Untagged Clone

CAT#: SC109105

CRK (untagged)-Human v-crk sarcoma virus CT10 oncogene homolog (avian) (CRK), transcript variant I


  "NM_005206" in other vectors (5)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CRK
Synonyms CRKII; p38
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_005206, the custom clone sequence may differ by one or more nucleotides


ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGG
TGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTA
TGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCG
GTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGT
TTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGATAGAACC
AGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTC
TTTGACTTTAATGGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACA
AGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAGCGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGT
CGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGGTCGGTGA


>OriGene 5' read for NM_005206 unedited
TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGTTCGGGCGCTGCTG
TGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGC
GCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCG
GAGGAGCGGAGTAGCTGGTACTGGGGGCGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTG
CAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTAT
GTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCG
CGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTCCAGACTC
CGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACAC
TATTTGGACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTG
ATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGGGAATGAT
GAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAG
CAGTGGTGGAATGCGGAGGACAGCGNAAGCAAGAGAGGGATGATTCCAGTCCCTTACGTC
GAGAAGTATAGACCTGCCTNCGCCTCAGTATCGGCTCTGATTGGAGGGTCGTGAGCTGGT
AAAGGNTACGAAGATTAATGTGAGTGGNTCANTGGGAANGGGGGAGTGTATGGCAANACG
AGTCACTTNCCATTACACATGTNCGTCTGCTGGATCAACAGAANTCCGATGAGGGACTCA
GCTGAGTATAGNTCAACAN
>OriGene 3' read for NM_005206 unedited
TTTTTTGCTTTGTACCGGCGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTGAG
ACTGAGTCTTGCCCTGTCGCTCAGGCTGGAACGCAGTGGTGCGATCTCGGCTCACTGCAG
CCTCCACCTCCCAGGTTGAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTAC
AGGCGTGCACCACCACGCCGGGCTAATTTTTTATATCTTTAGCAGAGATGGGGTCTCACT
ATGTCGGCCAGGCTGGCCTCGAACTCCTGACCTCATGATCCACCCGCCTCGGCCTTCCAA
AGTGCTGGGATTACAGACGTGAGCCACCGTGCCCAGTCGGTCCAACATTTTTTTAAAGCA
CTAACCCTACCCCAAATTCCTGTCACTACTAGCCCCGCCTCTTATCCCCGTTGCACCCCC
TCGCAGACGGCCCCAACCTGACCCCTAAACCCTCCCCCACCACTATTATTAGGTGATATG
TTCCCTGGGACCCACCCGACCCCCACCTTCGCGACCCCCCCCGAGGCTGCCTACTCCGCC
TCCCGCCCCCTCTCGCCCTACACGGCTCGTGTCGAGACATCCTAAATTTTCTTCCTTCTA
ATCATCCCCCCTCCCCTCCTTTTCGCATTCCCCCCCGTCCCCCCTCTCCCGCAACTCTTA
CACTATCTCCCCTTCCCCCCCCTCCGCCCCCCCACCCACCCCCACACCCCGCCTTCCTCC
TCCGCCCCCACCATGGTTTTCTCCCTCTTCCGCCGCCCTCTCNTCCCACATTATATTAAT
TAATTTCGCGGCCCCCGCCCGAACCGCCCTGCGTACCCTCTCGTTGTTGTGCACCTCCTT
TCTCTTTCCCTTCCCTTCCTTCCCTCTACACCATNTTCCCCCCCTATCCCTCCTCATTCA
TGATTTCCCGCCCCCGCGATAGCCCTACAGGCCACTCCCCCCGCCGCTTCGCGTCACCAC
CGCTCCCCCGCTCGTATCTCCCTGCCCT
Restriction Sites NotI-NotI     
ACCN NM_005206
ORF Size 615 bp
Insert Size 2190
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_005206.3, NP_005197.3
RefSeq Size 2245
RefSeq ORF 615
Locus ID 1398
Domains SH2, SH3
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma
Gene Summary This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (I) represents the shorter transcript and encodes the shorter isoform (b). Isoform b increases transformation activity due to the loss of a SH3 domain.

Other Versions

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.