p38 (CRK) (NM_005206) Human Untagged Clone

CAT#: SC320373

CRK (untagged)-Human v-crk sarcoma virus CT10 oncogene homolog (avian) (CRK), transcript variant I

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CRK
• Synonyms: CRKII; p38
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005206.3 GGGCACGAGGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGG
  GGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGC
  GGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGA
  GGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCAC
  CAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCAT
  CAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGT
  GAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGA
  ATTCTACAAAATACACTATTTGGACACTACAACGTTGATAGAACCAGTTTCCAGATCCAG
  GCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGA
  CTTTAATGGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCG
  GGACAAGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAGCGAAGGCAAGAGAGGGATGAT
  TCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGG
  AGGTCGGTGAGCTGGTAAAGGTTACGAAGATTAATGTGAGTGGTCAGTGGGAAGGGGAGT
  GTAATGGCAAACGAGGTCACTTCCCATTCACACATGTCCGTCTGCTGGATCAACAGAATC
  CCGATGAGGACTTCAGCTGAGTATAGTTCAACAGTTTTGCTGACAGATGGGAACAATCTT
  TTTTTTTTTTTTTCCAACTGCCATCTATACAATTTTCTTACAGATGTCAAAAGCAGTCTA
  GTTTATATAAGCATTCTGTTACCTGTGATATTTTTTAGACTGAACTGCTCCATTCCTAGT
  CTTAATTACCATATTCAGGGTACGAACTGGAGGGCTTGTGTGTTAGCTTCTGAATTGGCA
  ATTGGAGGCGGTAGTGGTCGTGCCTGTGTGTATCAGAAGGGATAGGTATCTTGCCTCCTT
  TCTCTCAGGCAGTGCAAATCACCCTGTGGAAAACCGATGGACAGGAAGGAGTGTTACACA
  CTGCTTACCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATCAAATGG
  CGACAGACTGTTCCGTTCCACCCCCGTGAAGTAATCATGCACCGTGTGAATAGTATCAAG
  CAGGATTGCTTTCATTGTATGGAGCATGACCAGCGTGTGACTCATTCTGACATTTCAGAT
  CCTAAGAATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCTTCATAC
  TTTTTCTTGGGATTCTTTTAGCCCTTGACATTCTTGTCCCCCAAACCTGTAAGTAGGTGA
  ATTCCTAAGATAAGTGTGTATTTTCATTCCAGGTGAAAAGCAGGATGTACCGAGCACTTT
  ATTCAGTGCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCTCCCAGC
  TCTCTGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCCTTCTACAGCAGCTAACTAGAGTC
  CTAACTAATGGGATCCAGCAGGGCCATTTCTCCAGAGGGCCAGTATCCTATTAGGAGACT
  CTTGGAATTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATTCTGTGG
  AAGGTTTTGGGGTCAAATTCTGCCCTCTGCATTCTGTGCAACTTGTATAAAAGTCAAGTT
  AGTATTACATGAATTTGGGGTAGGGTTAGTGCTTTGAAAAAATGTTGAACCGGCTGGGCG
  CGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGT
  CAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTGCTAAAGATATAAA
  AAATTAGCCCGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAG
  GAGAATTGCTTCAACCTGGGAGGTGGAGGCTGCAGTGAGCCGAGATCGCACCACTGCGTT
  CCAGCCTGAGCGACAGGGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005206.3 unedited
  TACTACTGAGCTACAACTTGTTGACTACTACTATACGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACT
  AGTTAGCGGACCGACGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAA
  GCAGGCTTGTAAAACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTG
  GCGAATTCGGGCACGAGGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGG
  GCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCA
  GCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGT
  CGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGAC
  TCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCAC
  TACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCG
  CCCGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCT
  TTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGATAGAACCAGTTTCC
  AGATCCAGGCAGGGTAGTGGAGTGATTCTCAGCAGGAGGAGCGGAGTATGTGCGAGCCCT
  CTTTGACTTTAATGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTGAGAT
  CCGGGACAAGCCTGAGAGCAGTGTGATGCGAGACAGCGAAGCAGAGAGGATGATTCAGTC
  CCTACGTCGAGAGTATAGACTGCTCGCTCAGTATCGCTCTGATTGAGTCGGTGAGCTGTA
  AGGTT
• Restriction Sites: Please inquire
• ACCN: NM_005206
• ORF Size: 615 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005206.3, NP_005197.3
• RefSeq Size: 2245
• RefSeq ORF: 615
• Locus ID: 1398
• Domains: SH2, SH3
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma
• Gene Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (I) represents the shorter transcript and encodes the shorter isoform (b). Isoform b increases transformation activity due to the loss of a SH3 domain.