DPP6 (NM_001936) Human Untagged Clone

CAT#: SC109170

DPP6 (untagged)-Human dipeptidyl-peptidase 6 (DPP6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DPP6
• Synonyms: DPL1; DPPX; MRD33; VF2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109170 sequence for NM_001936 edited (data generated by NextGen Sequencing)
  ATGACCACAGCCAAGGAGCCAAGCGCTTCGGGGAAATCCGTGCAGCAGCAGGAACAGGAG
  CTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTC
  ATTCTGGTCATCTGCTCCTTGATCGTCACCTCGGTCATACTTCTGACACCAGCGGAAGAT
  AATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTGAAGACTTCAAA
  ATTCATGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAA
  GGAACAGTGAGACTGTGGAATGTTGAAACAAATACTTCTACTGTCTTAATAGAAGGCAAA
  AAAATTGAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAGAGTATGCACTT
  TTTTCATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTATGTCCTGAGC
  AAAATTCCTCATGGGGATCCTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCAAAGCTT
  CAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGATATTTATTTTTGAAAACAATATC
  TACTACTGTGCACATGTCGGGAAACAGGCCATCCGTGTGGTCTCCACTGGCAAGGAAGGT
  GTGATTTACAATGGCCTCAGTGACTGGCTGTATGAAGAGGAGATTTTGAAGACACACATC
  GCACACTGGTGGTCTCCGGATGGCACGAGACTCGCCTACGCCGCCATCAATGATTCCCGT
  GTCCCCATCATGGAGCTCCCAACTTACACCGGCTCCATCTACCCCACCGTGAAGCCCTAC
  CACTATCCCAAGGCTGGAAGTGAGAACCCCAGCATTTCCCTACACGTTATTGGCTTAAAT
  GGACCCACCCATGATCTGGAGATGATGCCGCCTGATGATCCACGGATGAGGGAGTACTAC
  ATCACCATGGTGAAGTGGGCCACCAGCACCAAGGTCGCCGTGACCTGGCTGAACCGGGCG
  CAGAACGTGTCCATCCTCACCCTCTGCGACGCCACCACGGGGGTCTGCACGAAGAAACAC
  GAGGATGAAAGTGAGGCCTGGCTCCACAGACAGAATGAAGAACCTGTGTTCTCCAAGGAT
  GGCCGAAAGTTTTTCTTCATCAGAGCCATCCCCCAGGGAGGACGAGGGAAATTCTATCAC
  ATCACGGTGTCCTCGTCCCAGCCCAACAGCAGCAACGACAACATCCAGTCCATCACCTCC
  GGGGACTGGGACGTGACCAAGATCCTAGCCTACGATGAGAAGGGGAATAAGATCTACTTC
  CTGAGCACGGAGGACCTGCCTCGGAGACGACAACTCTACAGTGCCAACACGGTGGGCAAC
  TTCAACAGGCAGTGCCTCTCCTGTGACCTGGTTGAGAACTGCACCTACTTCAGCGCTTCC
  TTCAGCCATAGCATGGACTTCTTCCTGCTCAAGTGCGAAGGTCCTGGTGTTCCTATGGTG
  ACGGTGCACAACACAACAGATAAGAAAAAAATGTTTGACCTAGAAACAAATGAACATGTC
  AAGAAGGCCATAAATGACCGACAGATGCCTAAAGTGGAATACAGGGACATTGAGATTGAT
  GATTACAACCTGCCCATGCAGATACTGAAGCCAGCAACCTTCACCGACACCACCCACTAC
  CCTCTGCTCCTGGTGGTGGATGGCACCCCGGGCAGCCAGAGTGTGGCTGAGAAGTTCGAG
  GTGAGCTGGGAGACGGTGATGGTGAGCAGCCACGGCGCGGTGGTGGTAAAGTGTGACGGC
  CGTGGCAGCGGCTTCCAAGGGACCAAGCTCCTGCACGAAGTGAGGCGGCGGCTGGGCTTG
  CTGGAGGAGAAGGACCAGATGGAGGCCGTGCGGACGATGCTGAAGGAGCAGTACATTGAC
  AGGACGCGCGTGGCCGTGTTTGGGAAGGATTACGGTGGCTACCTGAGCACCTACATCCTC
  CCAGCAAAGGGAGAAAATCAAGGCCAGACATTCACCTGCGGCTCTGCTCTCTCTCCAATA
  ACAGACTTCAAACTCTATGCCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCATGGACTT
  GACAACAGAGCATACGAGATGACCAAGGTAGCCCATCGAGTCTCCGCGCTGGAAGAACAG
  CAGTTCCTGATCATTCATCCCACTGCCGATGAAAAAATTCATTTCCAGCACACAGCAGAA
  CTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAGATTTACCCGGACGAA
  AGCCATTACTTTACCAGCTCCAGCCTCAAACAGCATCTGTACCGGTCCATCATCAACTTC
  TTCGTGGAATGCTTCAGGATCCAGGACAAACTGCTGACAGTCACAGCGAAAGAGGACGAG
  GAGGAGGACTAA
  
  Clone variation with respect to NM_001936.3
  471 c=>t;537 a=>g;1710 a=>g
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001936 unedited
  GGTTCACATTTGTATACGACTCCTATAGGCGGCCGCGNAATTCGCACGAGGCGGGCGAGG
  AGGCAGCGCGCATCACTCGGGTCCCCTTCCTGCACCCAGCCGCCACTTGCCGGTTGCTAA
  GCAGTTATCATTGTTTCTGTGGCGATTGCAGAGGCTGTTGCTAATTGGAGAAGCCCCACT
  AAGCAGCGGCAGCTTCCTGCTTCGGATCCTCTCTCTGCTGCTTGCATTTAAAGAGCAAAC
  TCGCTNTGTCTACCCACCCTCCCTCCCCCATCCTCCCCAAAATAGCCTTGTGATTTCGGA
  AGTATGGACTAAAATCACACTCCTCCTTACCTTACCGCTTGGACTCTGGTGGCTCCCAAC
  TCGCCGTCAGACCCCACCTGCCCCGGTGGTGGGAAGCGCCTGGACAGACCATGACCACAG
  CCAAGGAGCCAAGCGCTTCGGGGAAATCCGTGCAGCAGCAGGAACAGGAGCTGGTGGGGA
  GTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATTCTGGTCA
  TCTGCTCCTTGATCGTCACCTCGGTCATACTTCTGACACCAGCGGAAGATAATAGTCTGT
  CTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTGAAGACTTCAAAATTCATGACC
  CCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGAACAGTGA
  GACTGTGGAATGTTGAAACAAATACTTCTACTGTCTTAATANGAAGCAAAAAAATTGAAT
  CATTAAGAGCCATCAGATATGANATATCTCCAGATAGAGAGTATGCACTNTTTTCATACC
  ATGTGGAAACCATATATCAACACTCGTATACTGGATATTATGTCCTGAGCAAATTCCTCA
  TGGNGATCCTCAAAGTCTGGACCCACN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001936 unedited
  ATGGACCGGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTAACCAAATG
  TCATGGGGAAAGAGCTTGATACGGTACCAAGGAGGACAAGGATGGTTGTAAGGACGGATG
  TAAATAGACAGTGCACACCTACAGCCAAGCCCTAGCATAGCTGAGTGGGAGAGAGGTTTT
  ATTTAGGTATTTCTTTTAATGGGTGCTATTGGCTGTCTTCCCCCTCAGTGTTTAGGAACG
  TCTCCAAGACGTCTGAAGACAACCTTGAGGAGGGAGCAGTTACTTCCGATCTGCTTCTTC
  ATCAAGCGCAAAGTCTACACGTGGACTGGAGAAAGGAAAGGGAAACAAGGCCCAACCCCA
  AACAGCAAAACAACCCCATGACGGAGACAGTGGAGCATCAGGTTAAAACCATAGAAAAAT
  ACGAGTTAATTCTATCAGGTTAACCATTAGCGTAGCTACAGTAAGACTCTGTACAGAAAA
  GCGTTTTCTTGTAGCCCCTCACCATGTTGAACGTCCTCATTACAGGAAGTAGCAAGCCCA
  TATATGAACACGCACTGCTAAAACAATGGTGCTGTAACTGCTGCGTCCATGGCACTGCGA
  CGTGAGACAGGGTGTGATGTCCCTAACGGGAACACAGAGGCTAGTGCGGGCGGGTCTCAC
  GCCTTCGCTTGGTGGCTGGAATTTAGGCGCCGGTGCTCTGTGGGCTCGGTGGGGCCTGTG
  GCCACCATCCTTTGCTCTGTTCCTTGCGGAAGGGGCCGTGGCGTGCCGCTCCTCTCGTTC
  GCCCTACGGAGGGCCTGCCGTGGCCCCACCGTCGCCCCCTGTGCCTGGGCGCCGGGACCG
  TGACCCCGGGCAAGCCCCTGTTTCCCCGCCTACTGTCTTCGCGTTTGAGAAACATGCTCG
  CCCCCCCGTGTCCCCCCGCCCTGCNTTCCCGGTCCAGTGGTGCCCTCCCCCTCTTCCTCC
  CTCTTGCCGTTCACCATTCCCCCCCCTTCGCTCTTCCTCCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001936
• Insert Size: 3460 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001936.2, NP_001927.2
• RefSeq Size: 3560 bp
• RefSeq ORF: 2412 bp
• Locus ID: 1804
• Cytogenetics: 7q36.2
• Domains: Peptidase_S9, DPPIV_N_term
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: 'This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]'
  Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2, also referred to as S) has a shorter and distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.