PTP epsilon (PTPRE) (NM_006504) Human Untagged Clone

CAT#: SC109676

PTPRE (untagged)-Human protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRE
• Synonyms: HPTPE; PTPE; R-PTP-EPSILON
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_006504 edited
  CGGCCGCGAAATTCGGCACGAGGCCTCGTGCCGAATTCGGCACGAGGGGAATACTCAGTA
  AATGATGTATTGCCTTTCGCATCAGTAGCCTGCTTGGAAATGTTCAAATTATCAGCCCAG
  GAGACTCCAGTGCTGTGGACATGGGTCTGAACGAATTGATCACCTAGGGGCTACTGAGAA
  CGCGGTGCTCTGTCCACCATGGAGCCCTTGTGTCCACTCCTGCTGGTGGGTTTTAGCTTG
  CCGCTCGCCAGGGCTCTCAGGGGCAACGAGACCACTGCCGACAGCAACGAGACAACCACG
  ACCTCAGGCCCTCCGGACCCGGGCGCCTCCCAGCCGCTGCTGGCCTGGCTGCTACTGCCG
  CTGCTGCTCCTCCTCCTCGTGCTCCTTCTCGCCGCCTACTTCTTCAGGTTCAGGAAGCAG
  AGGAAAGCTGTGGTCAGCACCAGCGACAAGAAGATGCCCAACGGAATCTTGGAGGAGCAA
  GAGCAGCAAAGGGTGATGCTGCTCAGCAGGTCACCCTCAGGGCCCAAGAAGTATTTTCCC
  ATCCCCGTGGAGCACCTGGAGGAGGAGATCCGTATCAGATCCGCCGACGACTGCAAGCAG
  TTTCGGGAGGAGTTCAACTCATTGCCATCTGGACACATACAAGGAACTTTTGAACTGGCA
  AATAAAGAAGAAAACAGAGAAAAAAACAGATATCCCAACATCCTTCCCAATGACCATTCT
  AGGGTGATTCTGAGCCAACTGGATGGAATTCCCTGTTCAGACTACATCAATGCTTCCTAC
  ATAGATGGTTACAAAGAGAAGAATAAATTCATAGCAGCTCAAGGTCCCAAACAGGAAACG
  GTTAACGACTTCTGGAGAATGGTCTGGGAGCAAAAGTCTGCGACCATCGTCATGTTAACA
  AACTTGAAAGAAAGGAAAGAGGAAAAGTGCCATCAGTACTGGCCCGACCAAGGCTGCTGG
  ACCTATGGAAACATCCGGGTGTGCGTGGAGGACTGCGTGGTTTTGGTCGACTACACCATC
  CGGAAGTTCTGCATACAGCCACAGCTCCCCGACGGCTGCAAAGCCCCCAGGCTGGTCTCA
  CAGCTGCACTTCACCAGCTGGCCCGACTTCGGAGTGCCTTTTACCCCCATTGGGATGCTG
  AAGTTCCTCAAGAAAGTAAAGACGCTCAACCCCGTGCACGCTGGGCCCATCGTGGTCCAC
  TGTAGCGCGGGCGTGGGCCGGACGGGCACCTTCATTGTGATCGATGCCATGATGGCCATG
  ATGCACGCGGAGCAGAAGGTGGATGTGTTTGAATTTGTGTCTCGAATCCGTAATCAGCGC
  CCTCAGATGGTTCAAACGGATATGCAGTACACGTTCATCTACCAAGCCTTACTCGAGTAC
  TACCTCTACGGGGACACAGAGCTGGACGTGTCCTCCCTGGAGAAGCACCTGCAGACCATG
  CACGGCACCACCACCCACTTCGACAAGATCGGGCTGGAGGAGGAGTTCAGGAAATTGACA
  AATGTCCGGATCATGAAGGAGAACATGAGGACGGGCAACTTGCCGGCAAACATGAAGAAG
  GCCAGGGTCATCCAGATCATCCCGTATGACTTCAACCGAGTGATCCTTTCCATGAAAAGG
  GGTCAAGAATACACAGACTACATCAACGCATCCTTCATAGACGGCTACCGACAGAAGGAC
  TATTTCATCGCCACCCAGGGGCCACTGGCACACACGGTTGAGGACTTCTGGAGGATGATC
  TGGGAATGGAAGTCCCACACTATCGTGATGCTGACGGAGGTGCAGGAGAGAGAGCAGGAT
  AAATGCTACCAGTATTGGCCAACCGAGGGCTCAGTTACTCATGGAGAAATAACGATTGAG
  ATAAAGAATGATACCCTTTCAGAAGCCATCAGTATACGAGACTTTCTGGTCACTCTCAAT
  CAGCCCCAGGCCCGCCAGGAGGAGCAGGTCCGAGTAGTGCGCCAGTTTCACTTCCACGGC
  TGGCCTGAGATCGGGATTCCCGCCGAGGGCAAAGGCATGATTGACCTCATCGCAGCCGTG
  CAGAAGCAGCAGCAGCAGACAGGCAACCACCCCATCACCGTGCACTGCAGTGCCGGAGCT
  GGGCGAACAGGTACATTCATAGCCCTCAGCAACATTTTGGAGCGAGTAAAAGCCGAGGGA
  CTTTTAGATGTATTTCAAGCTGTGAAGAGTTTACGACTTCAGAGACCACATATGGTGCAA
  ACCCTGGAACAGTATGAATTCTGCTACAAAGTGGTACAAGATTTTATTGATATATTTTCT
  GATTATGCTAATTTCAAATGAAGATTCCTGCCTTAAAATATTTTTTTAATTTAATGGTCA
  GTATATTTTGTAAAAATCATGTTAATTTATTTCATAGTTGACATTAATATCTTCCCTAAT
  TTCTTTGTATATATTTTGTTATGCCTTAAAGGCCACCTGCTATACAGTTGTTAAATCTTA
  AATATGCTTTTTAAAAATTGGATAATGTATTAAGGTCAAATAATATCCCATAAAATATAT
  ATTTCTGCTAATATTA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006504 unedited
  CTTGGGCCGGGCCTCGTGCCTTTTGGGGACGAGGGGNAATACTCAGTAAATGATGTATTG
  CCTTTCGCATCAGTAGCCTGCTTGGAAATGTTCAAATTATCAGCCCAGGAGACTCCAGTG
  CTGTGGACATGGGTCTGAACGAATTGATCACCTAGGGAGCTACTAGAAAACTCGGCTGCG
  CTGTCCACCATGGAGCCCTTGTGTCCACTCCTGCTGGTGGGTTTTAGCTTGCCGCTCGCC
  AGGGCTCTCAGGGGCAACGAGACCACTGCCGACAGCAACGAGACAACCACGACCTCAGGC
  CCTCCGGACCCGGGCGCCTCCCAGCCGCTGCTGGCCTGGCTGCTACTGCCGCTGCTGCTC
  CTCCTCCTCGTGCTCCTTCTCGCCGCCTACTTCTTCAGGTTCAGGAAGCAGAGGAAAGCT
  GTGGTCAGCACCAGCGACAAGAAGATGCCCAACGGAATCTTGGAGGAGCAAGAGCAGCAA
  AGGGTGATGCTGCTCAGCAGGTCACCCTCAGGGCCCAAGAAGTATTTTCCCATCCCCGTG
  GAGCACCTGGAGGAGGAGATCCGTATCAGATCCGCCGACGACTGCAAGCAGTTTCGGGAG
  GAGTTCAACTCATTGCCCTCTGGACACATACAAGGAACTTTTGAACCTGGCAATTACGAA
  GAAAACAGAGGAAAAAACAGATATCCCAACATCCTTTCAAAAGACCATTCTAGGGTGATC
  CTGAGCCAACTGGATGGAATTCCCTGTTCAGACTACATCAATGCTTCCCACTAGATGGTT
  ACAAAGAGGAAAATAAATTCCTAGCAGCCTAAGGTCCCAAACAGAAAACGGTAACGACTC
  CTGAAAATGGTCCCGGGAGCAAAATCTGCGACCTTCGTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006504 unedited
  NTTTCACTCTGGACCCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTC
  CCCGTCAGTCAATCTTATCTGGTAATGGGATCATTACTGTTATCCAGTGTCAATGGTCTC
  AGTAGTATTTCCATTCAAAAATAATTTAGCTTTTAAATTAAGGATTTCTCTTTTTGTTTT
  ATTAAACATTGAAAGGTGGGACTTTAAAAAATGGTATAAATCTAGATTTTAAGGATTCTT
  TTCTTACAAACTGTCTCAGCTTTTTACAAGAAATGTTTAAATACCAAAATGCTGCTCAGA
  AAATTTAAAGTTTAATTGCCCGTGGTTATTCTACTGTTTCTATCCTAATGTGTGCTCCTC
  TGTACTGCGTGTGTAAGACGCTCAGTTCATCTGAATGTTTGGATGGGAAGTTTTGTGTTG
  AGCCTCCAGGCATAGCACTGGACCAGCCCAGGCCGCTGTGGCAAAACGGGAGGGGAGAAT
  GGGAGAGGCAGCTGGTTTTTTTCTGAGGGTGGTCTGGGCCAAACGACAGGCAGCTGGACA
  GCAAATGGTGCTTTGGGGTGTAACTCCGATGGCTGGTTTTGTTGTACCCAACGCCGTGGG
  TCAACGGGACCACCCAGCATTTACATCTCTTCTCGTTCAGCCAAGATAGTGTAAACACAG
  TCTTGATGGTGTAGACACAGCATTTTAAAATATTATTTATAGTCACCAGCTACTCTAGTG
  TGTTTTAGACCTGGATTCAGGTTGTAAAGACTTCTTTGATCTTTAAATGTAAAGATAAAC
  CACATGGACCCGAAACTGAGAACTNTACACGAGTCCCCATTTACATTGTACCATCACGAA
  CAGTTTGCCTTCCAAAATGCTGCTGGTCAGGGTTGTGATCCACTGCTAGGAAAGGCCATT
  TCGCACTGACTTTTGAGTTTTAACCGTTTTCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006504
• Insert Size: 3460 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_006504.3, NP_006495.1
• RefSeq Size: 5376 bp
• RefSeq ORF: 2103 bp
• Locus ID: 5791
• Cytogenetics: 10q26.2
• Domains: Y_phosphatase, PTPc_motif
• Protein Families: Druggable Genome, Phosphatase, Transmembrane
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]'
  Transcript Variant: This variant (1) lacks a 5' exon compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. The encoded protein is a receptor type isoform of this PTP. Variants 1, 4, and 5 all encode the same isoform (1).