TBXAS1 (NM_001061) Human Untagged Clone

CAT#: SC109823

TBXAS1 (untagged)-Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1


  "NM_001061" in other vectors (5)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TBXAS1
Synonyms BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109823 sequence for NM_001061 edited (data generated by NextGen Sequencing)
ATGATGGAAGCCTTGGGGTTTCTAAAATTGGAAGTGAATGGCCCCATGGTGACGGTGGCC
CTGTCAGTGGCTCTCTTGGCCCTCCTGAAATGGTACTCCACATCAGCATTCTCAAGACTG
GAGAAGTTAGGCCTCAGACATCCCAAGCCTTCTCCTTTCATTGGAAACTTGACATTTTTC
CGCCAGGGTTTTTGGGAAAGCCAAATGGAGCTCAGAAAGCTGTATGGACCTCTGTGTGGG
TACTATCTTGGTCGTCGGATGTTTATTGTTATTTCTGAGCCAGACATGATCAAGCAGGTG
TTGGTTGAGAACTTCAGTAACTTTACCAACAGAATGGCGTCGGGTTTGGAGTTCAAGTCG
GTAGCCGACAGCGTTCTGTTTTTACGTGACAAAAGATGGGAAGAGGTCAGAGGTGCCCTG
ATGTCTGCTTTCAGTCCTGAAAAGCTGAACGAGATGGTTCCCCTCATCAGCCAAGCCTGC
GACCTTCTCCTGGCTCATTTAAAACGCTATGCGGAATCTGGGGACGCATTTGACATCCAG
AGGTGCTACTGCAATTACACCACAGATGTGGTTGCCAGCGTCGCCTTTGGCACCCCGGTG
GACTCCTGGCAGGCCCCTGAGGATCCCTTTGTGAAACACTGCAAGCGTTTCTTCGAATTC
TGCATCCCCAGACCTATCCTGGTTTTACTCTTATCATTTCCATCCATAATGGTCCCACTG
GCCCGGATTTTGCCCAATAAGAACCGAGACGAACTGAATGGCTTTTTTAACAAACTCATT
AGGAATGTGATTGCCTTGCGGGACCAGCAAGCTGCCGAAGAGAGGCGGAGAGACTTCCTC
CAAATGGTCCTGGATGCCCGACATTCTGCAAGTCCCATGGGCGTGCAAGACTTTGACATC
GTCAGAGACGTTTTCTCCTCTACTGGGTGCAAGCCGAACCCTTCCCGGCAACACCAGCCC
AGCCCTATGGCCAGGCCTTTGACTGTGGATGAGATTGTGGGCCAGGCCTTCATCTTCCTC
ATCGCTGGCTATGAAATCATCACCAACACACTTTCTTTTGCCACCTACCTACTGGCCACC
AACCCTGACTGCCAAGAGAAGCTTCTGAGAGAGGTAGACGTTTTTAAGGAGAAACACATG
GCCCCTGAGTTCTGCAGCCTCGAGGAAGGCCTGCCCTATCTGGACATGGTGATTGCAGAG
ACGCTGAGGATGTACCCGCCAGCTTTCAGATTCACACGGGAGGCAGCTCAGGACTGCGAG
GTGCTGGGGCAGCGCATCCCCGCAGGCGCTGTGCTAGAGATGGCCGTGGGTGCCCTGCAC
CATGACCCTGAGCACTGGCCAAGCCCGGAGACCTTCAACCCTGAAAGGTTCACGGCTGAG
GCCCGGCAGCAGCACCGGCCCTTCACGTACCTGCCCTTCGGGGCCGGCCCACGGAGCTGC
CTCGGGGTGCGTCTAGGGCTGCTTGAGGTCAAGTTGACACTGCTCCACGTGCTGCACAAG
TTCCGGTTCCAAGCCTGCCCTGAGACCCAGGTACCGCTGCAGCTAGAATCCAAATCTGCC
CTAGGTCCAAAAAATGGTGTCTATATCAAGATCGTATCCCGCTGA

Clone variation with respect to NM_001061.4
>OriGene 5' read for NM_001061 unedited
TATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGCCTCGTGCCGAATTCGGCACGA
GGGTGATGTTTGCTTGGTTGCCTGTTCCCTTTTCTACCTGCAGAGCACGGTTCCCATAAG
GGCGGCGAGATCAGCCTCCTGTCTCATCTGGAAGACCACCACTCTGGGGTCTCAGAGGAA
TGATGGAAGCCTTGGGGTTTCTAAAATTGGAAGTGAATGGCCCCATGGTGACGGTGGCCC
TGTCAGTGGCTCTCTTGGCCCTCCTGAAATGGTACTCCACATCAGCATTCTCAAGACTGG
AGAAGTTAGGCCTCAGACATCCCAAGCCTTCTCCTTTCATTGGAAACTTGACATTTTTCC
GCCAGGGTTTTTGGGAAAGCCAAATGGAGCTCAGAAAGCTGTATGGACCTCTGTGTGGGT
ACTATCTTGGTCGTCGGATGTTTATTGTTATTTCTGAGCCAGACATGATCAAGCAGGTGT
TGGTTGAGAACTTCAGTAACTTTACCAACAGAATGGCGTCGGGTTTGGAGTTCAAGTCGG
TAGCCGACAGCGTTCTGTTTTTACGTGACAAAAGATGGGAAGAGGTCAGAGGTGCCCTGA
TGTCTGCTTTCAGTCCTGAAAAGCTGAACGAGATGGTTCCCCTCATCAGCCAAGCCTGCG
ACCTTCTCCTGGCTCATTTAAAACGCTATGCGGAATCTGGGGACGCATTTGACTCCAGAG
GTGCTACTGCAATTACCCACAGATGTGGTTGCCAGCGTCGCCTTGGCACCCCGTGGACTC
CTGGNCAGCCCTTGAGATCCCTTTTGTGAACACTGCAGCGTTTCTTCGAATCTGCATCCC
AGACTATNCNGGNTTTACTCTTATCATTTCTCCATATGGNCCACTGCCCCNGATTTTGCC
AATAGACCGAGAGACT
>OriGene 3' read for NM_001061 unedited
GCAACTTTCCAGGGCCAGGAAGNAGCACTGGGGNAGGGTCACAGGGATGCCACCCGGGAT
CTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGNTTTTTTTTTTTTTT
TTTTTTTTTCCAAGGGCAACAAACGTTTATTAAGCATTTAGGAAATGTTATGTAAAGAAC
CTTTTATCCTTGCATGCCAGGCACTCTTTCAATCACTTCAGGGACATTTTTCCAAAATTC
TGAACATCCACACTTAGGGTTTTCTTTGAATTTGGGGGGGCCCTCCCCCCACCCGGCAGC
CTTTTGTGTCAGCGGGATACGATCTTGATATAAACACCATTTTTTGGACCTAGGGCAGAT
TTGGATTCTAGCTGCAGCGGTACCTGGGTCTCAGGGCAGGCTTGGAACCGGAACTTGTGG
NNNACGTGGAGCAGTGTCAACTTGACCTCAAGCAGCCCTAAACGCACCCCGAGGCAGCTC
CGTGGGCCGGCCCCGAAGGGCAGGTACGTGAAGGGCCGGTGCTGCTGCCGGGCNCTCACC
GTGAACCTTTCAGGGTTGAAGGTCTCCGGGCTTGGCCAGTGCTCAGGGTCATGGGGCAGG
GCACCCACGGCCATCTCTAGCACANCGCCTGCGGGGATGCGCTTGCCCAGCACCTCGCAG
TCCTGAGCTGCCTCCCGTGGGAATTGAAAGCTGGCGGGACATCCTCAGCGGTTCTGCAAT
CACCATGTCCACAAAGNNNNACCCTCCTCGAGGCTGCAAACTCAGGGGCCATGGGTTTCT
CTTAAAAACGTCTACCTCTTTCAAAACTTTTCTTGGCAATAAGGGTTGGGTGGCACGTAG
GTAGTGGCAAAGAAAGAGGTGTGGGTGAAGATCTATTACCCACGATAGGAAAATGAAGGC
TTGCCCACATTTCTTCCAGGCAAGGGCGGCATAGGG
Restriction Sites NotI-NotI     
ACCN NM_001061
Insert Size 1960 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001061.2, NP_001052.1
RefSeq Size 1946 bp
RefSeq ORF 1605 bp
Locus ID 6916
Cytogenetics 7q34
Domains p450
Protein Families Druggable Genome, P450
Protein Pathways Arachidonic acid metabolism, Metabolic pathways
Gene Summary 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]'
Transcript Variant: This variant (1, also known as TXS-I) encodes isoform 1, which is also known as isoform TXS-I. Both variants 1 and 3 encode the same isoform. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is better supported by available conservation data and peptide data. This CCDS represents use of a downstream start codon, shortening the protein by a single amino acid.

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