Sulfatase 2 (SULF2) (NM_198596) Human Untagged Clone

CAT#: SC110537

SULF2 (untagged)-Human sulfatase 2 (SULF2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SULF2
• Synonyms: HSULF-2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110537 sequence for NM_198596 edited (data generated by NextGen Sequencing)
  ATGGGCCCCCCGAGCCTCGTGCTGTGCTTGCTGTCCGCAACTGTGTTCTCCCTGCTGGGT
  GGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGACCGCAGG
  AACATCCGCCCCAACATCATCCTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCC
  ATGCAGGTGATGAACAAGACCCGGCGCATCATGGAGCAGGGCGGGGCGCACTTCATCAAC
  GCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACCGGCAAGTAC
  GTCCACAACCACAACACCTACACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCA
  CAGCACGAGAGCCGCACCTTTGCCGTGTACCTCAATAGCACTGGCTACCGGACAGCTTTC
  TTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAAGGAGTGG
  GTCGGACTCCTTAAAAACTCCCGCTTTTATAACTACACGCTGTGTCGGAACGGGGTGAAA
  GAGAAGCACGGCTCCGACTACTCCAAGGATTACCTCACAGACCTCATCACCAATGACAGC
  GTGAGCTTCTTCCGCACGTCCAAGAAGATGTACCCGCACAGGCCAGTCCTCATGGTCATC
  AGCCATGCAGCCCCCCACGGCCCTGAGGATTCAGCCCCACAATATTCACGCCTCTTCCCA
  AACGCATCTCAGCACATCACGCCGAGCTACAACTACGCGCCCAACCCGGACAAACACTGG
  ATCATGCGCTACACGGGGCCCATGAAGCCCATCCACATGGAATTCACCAACATGCTCCAG
  CGGAAGCGCTTGCAGACCCTCATGTCGGTGGACGACTCCATGGAGACGATTTACAACATG
  CTGGTTGAGACGGGCGAGCTGGACAACACGTACATCGTATACACCGCCGACCACGGTTAC
  CACATCGGCCAGTTTGGCCTGGTGAAAGGGAAATCCATGCCATATGAGTTTGACATCAGG
  GTCCCGTTCTACGTGAGGGGCCCCAACGTGGAAGCCGGCTGTCTGAATCCCCACATCGTC
  CTCAACATTGACCTGGCCCCCACCATCCTGGACATTGCAGGCCTGGACATACCTGCGGAT
  ATGGACGGGAAATCCATCCTCAAGCTGCTGGACACGGAGCGGCCGGTGAATCGGTTTCAC
  TTGAAAAAGAAGATGAGGGTCTGGCGGGACTCCTTCTTGGTGGAGAGAGGCAAGCTGCTA
  CACAAGAGAGACAATGACAAGGTGGACGCCCAGGAGGAGAACTTTCTGCCCAAGTACCAG
  CGTGTGAAGGACCTGTGTCAGCGTGCTGAGTACCAGACGGCGTGTGAGCAGCTGGGACAG
  AAGTGGCAGTGTGTGGAGGACGCCACGGGGAAGCTGAAGCTGCATAAGTGCAAGGGCCCC
  ATGCGGCTGGGCGGCAGCAGAGCCCTCTCCAACCTCGTGCCCAAGTACTACGGGCAGGGC
  AGCGAGGCCTGCACCTGTGACAGCGGGGACTACAAGCTCAGCCTGGCCGGACGCCGGAAA
  AAACTCTTCAAGAAGAAGTACAAGGCCAGCTATGTCCGCAGTCGCTCCATCCGCTCAGTG
  GCCATCGAGGTGGACGGCAGGGTGTACCACGTAGGCCTGGGTGATGCCGCCCAGCCCCGA
  AACCTCACCAAGCGGCACTGGCCAGGGGCCCCTGAGGACCAAGATGACAAGGATGGTGGG
  GACTTCAGTGGCACTGGAGGCCTTCCCGACTACTCAGCCGCCAACCCCATTAAAGTGACA
  CATCGGTGCTACATCCTAGAGAACGACACAGTCCAGTGTGACCTGGACCTGTACAAGTCC
  CTGCAGGCCTGGAAAGACCACAAGCTGCACATCGACCACGAGATTGAAACCCTGCAGAAC
  AAAATTAAGAACCTGAGGGAAGTCCGAGGTCACCTGAAGAAAAAGCGGCCAGAAGAATGT
  GACTGTCACAAAATCAGCTACCACACCCAGCACAAAGGCCGCCTCAAGCACAGAGGCTCC
  AGTCTGCATCCTTTCAGGAAGGGCCTGCAAGAGAAGGACAAGGTGTGGCTGTTGCGGGAG
  CAGAAGCGCAAGAAGAAACTCCGCAAGCTGCTCAAGCGCCTGCAGAACAACGACACGTGC
  AGCATGCCAGGCCTCACGTGCTTCACCCACGACAACCAGCACTGGCAGACGGCGCCTTTC
  TGGACACTGGGGCCTTTCTGTGCCTGCACCAGCGCCAACAATAACACGTACTGGTGCATG
  AGGACCATCAATGAGACTCACAATTTCCTCTTCTGTGAATTTGCAACTGGCTTCCTAGAG
  TACTTTGATCTCAACACAGACCCCTACCAGCTGATGAATGCAGTGAACACACTGGACAGG
  GATGTCCTCAACCAGCTACACGTACAGCTCATGGAGCTGAGGAGCTGCAAGGGTTACAAG
  CAGTGTAACCCCCGGACTCGAAACATGGACCTGGATGGAGGAAGCTATGAGCAATACAGG
  CAGTTTCAGCGTCGAAAGTGGCCAGAAATGAAGAGACCTTCTTCCAAATCACTGGGACAA
  CTGTGGGAAGGCTGGGAAGGTTAA
  
  Clone variation with respect to NM_198596.2
  291 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_198596 unedited
  NGTCAGATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACCAGAGACGCAACTT
  GAGACTCCCGCATCCCAAAAAAAGCACCAGATCAGCAAAAAAAGAAGATGGGCCCCCCGA
  GCCTCGTGCTGTGCTTGCTGTCCGCAACTGTGTTCTCCCTGCTGGGTGGAAGCTCGGCCT
  TCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGACCGCAGGAACATCCGCCCCA
  ACATCATCCTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCCATGCAGGTGATGA
  ACAAGACCCGGCGCATCATGGAGCAGGGCGGGGCGCACTTCATCAACGCCTTCGTGACCA
  CACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACCGGCAAGTACGTCCACAACCACA
  ACACCTACACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCACAGCACGAGAGCC
  GCACCTTTGCCGTGTACCTCAATAGCACTGGCTACCGGACAGCTTTCTTCGGGAAGTATC
  TTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAAGGAGTGGGTCGGACTCCTTA
  AAAACTCCCGCTTTTATAACTACACGCTGTGTCGGAACGGNGTGAAAGAGAAGCACGGCT
  CCGACTACTCCAAGGATTACCTCACAGACCTCATCACCAATGACAGCGTGAGCTTCTTCC
  GCACGTCCAAGAAGATGTACCCGCACAGGCCAGTCCTCATGGTCATCAGCCATGCAGCCC
  CCCACGGCCCTGAGATCAGCCCCACATATCACGCCTCTTCCAACGCATCTCACACTCACG
  CCGAGCTACACTACGCGCCCAACCGGACAACACTGNATCATGCGCTACACGGNGCCCATG
  AAGCCCATCCACTGGNAATCACCACATGCTCAGCGAAGCGCTTGCAGACCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_198596 unedited
  CATTTGGACCGCGCCGCATTCTANGATCGATTTTTTTTTTTTTTTTTTTTTTTTTTCTTT
  TACACTGGCCACAGAGCGTTTATTGACACCACCACTCCTGAAAATTGGGATTTCTTATTA
  GGTTCCCCTAAAAGTTCCCATGTTGATTACATGTAAATAGTCACATATATACAATGAAGG
  CAGTTTCTTCAAAGGCAACCAGGGTTTATAGTGCTAGGTAAATGTCATCTCTTTTGTGCT
  ACTGACTCATTGTCAAACGTCTCTGCACTGTTTTCAGCCTCTCCACGTTGCCTCTGTCCT
  GCTTCTTAGTTCCTTCTTTGTGACAAACCAAAAGAATAAGAGGATTTAGAACAGGACTGC
  TTTTCCCCTATGATTTAAAAATTCCAATGACTTTCGCCCTTGGGAGAAATTTCCAAGGAA
  ATCTCTCTCGCTCGCTCTCTCCGTTTTCCTTTGTGAGCTTCTGGGGGAGGGTTAGTGGTG
  ACTTTTTGATACGAAAAAATGCATTTTGTGCAGCTGGTGAGGTATAATCCAAAGCAAAAG
  CAGGGGCAAAAATGGACTTCCTGAAGTTATCTCTGCTCCTGCTGGTTATCCTCCAGAATC
  TGTCATGTTGACTGAAAGTGCGTGCTTGCTTTCTCAGGCCTCCTGGCCAATAGCACAGGT
  CTGCTGGAAATCACCCACATGGTTTTTCATTGCCTGTGCAGTCAGGTGATGCCTCTATGT
  TTTTGGAGGTCCACCTCTGTTGTTTTCTTAACTTTCCCACCCTTCCCAAGTTTGTCCAAT
  GATTTGGAAGAAAGTCCCTTCATTTCTGCCCATTTCAACGCCTGAAACTGCCTGATTGCT
  CAAAACTTCCTCCATCTTTAAATCCCAGGCCATGGTTCNAGTCCGGGGGTTACACTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_198596
• ORF Size: 2559 bp
• Insert Size: 4000
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_198596.1, NP_940998.1
• RefSeq Size: 4239
• RefSeq ORF: 2559
• Locus ID: 55959
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]). [supplied by OMIM, Mar 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.