HIF 2 alpha (EPAS1) (NM_001430) Human Untagged Clone

CAT#: SC110883

EPAS1 (untagged)-Human endothelial PAS domain protein 1 (EPAS1)


  "NM_001430" in other vectors (7)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol EPAS1
Synonyms bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_001430 edited
CCCGCCCGGGCCGCGGGGAGCGGACGAGGGCCACAGCCCCCCACCCGCCAGGGAGCCCAG
GTGCTCGGCGTCTGAACGTCTCAAAGGGCCACAGCGACAATGACAGCTGACAAGGAGAAG
AAAAGGAGTAGCTCGGAGAGGAGGAAGGAGAAGTCCCGGGATGCTGCGCGGTGCCGGCGG
AGCAAGGAGACGGAGGTGTTCTATGAGCTGGCCCATGAGCTGCCTCTGCCCCACAGTGTG
AGCTCCCATCTGGACAAGGCCTCCATCATGCGACTGGCAATCAGCTTCCTGCGAACACAC
AAGCTCCTCTCCTCAGTTTGCTCTGAAAACGAGTCCGAAGCCGAAGCTGACCAGCAGATG
GATAACTTGTACCTGAAAGCCTTGGAGGGTTTCATTGCCGTGGTGACCCAAGATGGCGAC
ATGATCTTTCTGTCAGAAAACATCAGCAAGTTCATGGGACTTACACAGGTGGAGCTAACA
GGACATAGTATCTTTGACTTCACTCATCCCTGCGACCATGAGGAGATTCGTGAGAACCTG
AGTCTCAAAAATGGCTCTGGTTTTGGGAAAAAAAGCAAAGACATGTCCACAGAGCGGGAC
TTCTTCATGAGGATGAAGTGCACGGTCACCAACAGAGGCCGTACTGTCAACCTCAAGTCA
GCCACCTGGAAGGTCTTGCACTGCACGGGCCAGGTGAAAGTCTACAACAACTGCCCTCCT
CACAATAGTCTGTGTGGCTACAAGGAGCCCCTGCTGTCCTGCCTCATCATCATGTGTGAA
CCAATCCAGCACCCATCCCACATGGACATCCCCCTGGATAGCAAGACCTTCCTGAGCCGC
CACAGCATGGACATGAAGTTCACCTACTGTGATGACAGAATCACAGAACTGATTGGTTAC
CACCCTGAGGAGCTGCTTGGCCGCTCAGCCTATGAATTCTACCATGCGCTAGACTCCGAG
AACATGACCAAGAGTCACCAGAACTTGTGCACCAAGGGTCAGGTAGTAAGTGGCCAGTAC
CGGATGCTCGCAAAGCATGGGGGCTACGTGTGGCTGGAGACCCAGGGGACGGTCATCTAC
AACCCTCGCAACCTGCAGCCCCAGTGCATCATGTGTGTCAACTACGTCCTGAGTGAGATT
GAGAAGAATGACGTGGTGTTCTCCATGGACCAGACTGAATCCCTGTTCAAGCCCCACCTG
ATGGCCATGAACAGCATCTTTGATAGCAGTGGCAAGGGGGCTGTGTCTGAGAAGAGTAAC
TTCCTATTCACCAAGCTAAAGGAGGAGCCCGAGGAGCTGGCCCAGCTGGCTCCCACCCCA
GGAGACGCCATCATCTCTCTGGATTTCGGGAATCAGAACTTCGAGGAGTCCTCAGCCTAT
GGCAAGGCCATCCTGCCCCCGAGCCAGCCATGGGCCACGGAGTTGAGGAGCCACAGCACC
CAGAGCGAGGCTGGGAGCCTGCCTGCCTTCACCGTGCCCCAGGCAGCTGCCCCGGGCAGC
ACCACCCCCAGTGCCACCAGCAGCAGCAGCAGCTGCTCCACGCCCAATAGCCCTGAAGAC
TATTACACATCTTTGGATAACGACCTGAAGATTGAAGTGATTGAGAAGCTCTTCGCCATG
GACACAGAGGCCAAGGACCAATGCAGTACCCAGACGGATTTCAATGAGCTGGACTTGGAG
ACACTGGCACCCTATATCCCCATGGACGGGGAAGACTTCCAGCTAAGCCCCATCTGCCCC
GAGGAGCGGCTCTTGGCGGAGAACCCACAGTCCACCCCCCAGCACTGCTTCAGTGCCATG
ACAAACATCTTCCAGCCACTGGCCCCTGTAGCCCCGCACAGTCCCTTCCTCCTGGACAAG
TTTCAGCAGCAGCTGGAGAGCAAGAAGACAGAGCCCGAGCACCGGCCCATGTCCTCCATC
TTCTTTGATGCCGGAAGCAAAGCATCCCTGCCACCGTGCTGTGGCCAGGCCAGCACCCCT
CTCTCTTCCATGGGGGGCAGATCCAATACCCAGTGGCCCCCAGATCCACCATTACATTTT
GGGCCCACAAAGTGGGCCGTCGGGGATCAGCGCACAGAGTTCTTGGGAGCAGCGCCGTTG
GGGCCCCCTGTCTCTCCACCCCATGTCTCCACCTTCAAGACAAGGTCTGCAAAGGGTTTT
GGGGCTCGAGGCCCAGACGTGCTGAGTCCGGCCATGGTAGCCCTCTCCAACAAGCTGAAG
CTGAAGCGACAGCTGGAGTATGAAGAGCAAGCCTTCCAGGACCTGAGCGGGGGGGACCCA
CCTGGTGGCAGCACCTCACATTTGATGTGGAAACGGATGAAGAACCTCAGGGGTGGGAGC
TGCCCTTTGATGCCGGACAAGCCACTGAGCGCAAATGTACCCAATGATAAGTTCACCCAA
AACCCCATGAGGGGCCTGGGCCATCCCCTGAGACATCTGCCGCTGCCACAGCCTCCATCT
GCCATCAGTCCCGGGGAGAACAGCAAGAGCAGGTTCCCCCCACAGTGCTACGCCACCCAG
TACCAGGACTACAGCCTGTCGTCAGCCCACAAGGTGTCAGGCATGGCAAGCCGGCTGCTC
GGGCCCTCATTTGAGTCCTACCTGCTGCCCGAACTGACCAGATATGACTGTGAGGTGAAC
GTGCCCGTGCTGGGAAGCTCCACGCTCCTGCAAGGAGGGGACCTCCTCAGAGCCCTGGAC
CAGGCCACCTGAGCCAGGCCTTCTACCTGGGCAGCACCTCTGCCGACGCCGTCCCACCAG
CTTCACTCTCTCCGTCTGTTTTTGCAACTAGGTATTTCTAACGCCAGCACAC
>OriGene 5' read for NM_001430 unedited
CCCAATCGCCGCCCGTTGCCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAA
GCAGAGTTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG
CGAATTCGGCACGAGGGCCACACGGGTCCGGTGCCCGCTGCGCTTCCGCCCCAGCGCTCC
TGAGGCGGCCGTACAATCCTCGGCAGTGTCCTGAGACTGTATGGTCAGCTCAGCCCGGCC
TCCGACTCCTTCCGACTCCCAGCATTCGAGCCACTTTTTTTTTCTTTGAAAACTCAGAAA
AGTGACTCCTTTTCCAGGGAAAAAGGAACTTGGGTTCCCTTCTCTCCGTCCTCTTTTCGG
GTCTGACAGCCTCCACCCACTCCTTCCCCGGACCCCGCCTCCGCGCGCAGGTTCCTCCCA
GTCACCTTTCTCCACCCCCGCCCCCGCACCTAGCCCGCCGCGCGCCACCTTCCACCTGAC
TGCGCGGGGCGCTCGGGACCTGCGCGCACCTCGGACCTTCACCACCCGCCCGGGCCGCGG
GGAGCGGACGAGGGCCACAGCCCCCCACCCGCCAGGGAGCCCAGGTGCTCGGCGTCTGAA
CGTCTCAAAGGGCCACAGCGACAATGACAGCTGACCAGGAGAAGACAAGGAGTAGCTCGG
AGAGGTAGAAGGAGAAGTCCCTGGATGCTGCGCGGTGCCTGCCGGAGCAGGAGACGGAGG
TGTTCTATGAGCTGGCCCATGAGCTGCCTCTGCCCCACAGTGTGAGCTCCCATCTGGACC
AGGTCTCCATCATGCGACTGGCAATCAGTTTCCTGGGACACACAGCTCCTCTCCTCAGAT
TGCTCTGAAAACGAGTCCGAAGCCCCAGCTGACCACCAGAGGGATAACTTGTACCTGAAG
CCTTTGAAGGTT
>OriGene 3' read for NM_001430 unedited
CACTGGGGGCAGGGGTACACAGGGCATGCCACCCGGGTTCTGTTCAGGAAACAGCTATGA
CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAGGATCAAGATACTTTAA
TAAGATACCAGTGTCAAAATACATTTCCTTATAAAGTTAAGCTCCCATACAGTTATAATG
TTGTCTGTTGGAATTCGACAATATAATAACGTTCATGAAATCGTTACGTTGACAGGTAGG
GTTAATATGAAGCTTGGAATATTTTTCAGTGTTTTAGTAAAACTGCAAGGGTAAAATGCC
CTTAATGCCAGGGCAACACACACAGGAAATCAAATACCAGCATTTACACGTCAGTAACCC
TTCAAGTTCTGCCACCCTGTGTGGGGTAATGCCGTGCAGCTAAAATATGATTTACGCAAC
ACCATGACTAAGGAATTTCTCATAGAACTTAAATTTCTTTTGAAAGCTATTTTTTGTTTT
TGGCAATAAGTCTATCCGGGCTTACTAAATAGTTGGCCCAATGTGCTTTGTGTGTGTTTT
TAGAAACTTCTTCATTGTACCCATTACAGAAAAGTTCCATGTTATTGGTATTGAAAAACC
AGAGGTGTCGTCCCTCTTACCCAGGGAGTTGCAAAGTGCTCTGGGAACACTATTTTCAGT
GCTTCCTACCTACATGTCACTGACCGACCCATAGACCTCAGCCAGGGCCTGTGGCTAGGG
GCCATCCCTGGAAGCCTTGGGGGCCATCTGCCTGCCGGCTGAATGGGGGCTGCAGGGCTG
GTCTTGGACAGCTGCTCTCCCGTTGTGCAGCCTTCTTCTAAGTCCACCTCCAGGGGCTCC
AAGGTCTGAACTTGAAAGN
Restriction Sites NotI-NotI     
ACCN NM_001430
Insert Size 5500 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001430.3, NP_001421.2
RefSeq Size 5186 bp
RefSeq ORF 2613 bp
Locus ID 2034
Cytogenetics 2p21
Domains PAS, HLH, PAC
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Pathways in cancer, Renal cell carcinoma
Gene Summary 'This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]'

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.