FBXO11 (NM_025133) Human Untagged Clone

CAT#: SC110924

FBXO11 (untagged)-Human F-box protein 11 (FBXO11), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FBXO11
• Synonyms: FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110924 sequence for NM_025133 edited (data generated by NextGen Sequencing)
  ATGGTTGCAGAAGAATCAGGTCCTGGTGCACAAAATAGTCCATACCAACTTCGTAGAAAA
  ACTCTTTTGCCGAAAAGAACAGCGTGTCCCACAAAGAACAGTATGGAGGGCGCCTCAACT
  TCAACTACAGAAAACTTTGGTCATCGTGCAAAACGTGCAAGAGTGTCTGGAAAATCACAA
  GATCTATCAGCAGCACCTGCTGAACAGTATCTTCAGGAGAAACTGCCAGATGAAGTGGTT
  CTAAAAATCTTCTCTTACTTGCTGGAACAGGATCTTTGTAGAGCAGCTTGTGTATGTAAA
  CGCTTCAGTGAACTTGCTAATGATCCAATTTTGTGGAAACGATTATATATGGAAGTATTT
  GAATATACTCGCCCTATGATGCATCCTGAACCTGGAAAATTCTACCAGATTAATCCAGAA
  GAGTATGAACATCCAAATCCCTGGAAAGAGAGTTTCCAGCAGTTGTATAAAGGTGCACAT
  GTAAAGCCAGGATTTGCTGAACATTTCTACAGTAACCCTGCAAGATATAAAGGAAGAGAA
  AATATGTTGTATTATGATACTATTGAAGATGCCCTTGGTGGGGTACAAGAGGCTCATTTT
  GATGGACTTATCTTTGTTCATTCTGGAATATATACTGATGAATGGATATATATTGAATCT
  CCAATCACCATGATTGGTGCAGCACCTGGGAAAGTGGCAGACAAAGTTATAATTGAAAAC
  ACTAGAGATTCAACCTTCGTTTTTATGGAAGGCTCTGAAGATGCTTATGTTGGATATATG
  ACAATAAGGTTTAACCCTGATGACAAATCTGCACAACACCACAATGCACACCACTGCTTA
  GAGATTACAGTAAATTGTAGCCCTATTATTGATCACTGTATCATCCGAAGTACATGTACA
  GTTGGTTCTGCAGTATGTGTTAGTGGTCAAGGAGCATGTCCCACCATCAAGCACTGTAAC
  ATCAGTGACTGTGAAAATGTTGGACTATATATAACAGATCATGCACAGGGAATATATGAG
  GATAATGAAATTTCCAATAATGCGTTAGCTGGGATTTGGGTTAAAAATCATGGAAACCCA
  ATTATTAGACGGAATCATATTCATCATGGACGTGATGTTGGTGTGTTCACATTTGATCAT
  GGCATGGGTTACTTTGAAAGTTGCAATATACACAGAAATAGGATAGCAGGCTTTGAAGTA
  AAAGCCTATGCTAACCCTACAGTGGTTCGATGTGAAATTCACCATGGGCAGACTGGAGGA
  ATATATGTCCATGAAAAAGGAAGAGGACAATTCATAGAGAATAAAATCTATGCAAACAAC
  TTTGCAGGTGTATGGATTACCTCAAATAGTGACCCAACAATAAGGGGAAATTCTATATTT
  AATGGAAATCAAGGAGGAGTTTACATCTTTGGTGATGGACGAGGCCTTATTGAAGGAAAT
  GACATTTATGGCAATGCATTAGCAGGAATTCAAATTAGGACAAACAGTTGTCCAATTGTT
  CGGCATAACAAAATTCATGATGGCCAGCATGGTGGGATTTATGTGCATGAAAAGGGACAA
  GGAGTAATAGAAGAGAATGAAGTTTATAGTAACACTCTAGCTGGAGTCTGGGTGACAACT
  GGCAGCACTCCAGTACTGAGAAGAAACCGGATACACAGTGGCAAGCAGGTTGGTGTTTAT
  TTTTATGACAATGGACATGGAGTGCTAGAAGACAATGATATCTATAATCATATGTATTCA
  GGGGTTCAGATAAGGACTGGAAGCAACCCCAAAATTAGACGCAACAAAATCTGGGGAGGA
  CAGAATGGTGGAATTCTAGTTTATAATTCTGGTCTAGGCTGTATAGAAGACAATGAAATA
  TTTGACAATGCAATGGCTGGAGTCTGGATTAAGACAGATAGTAATCCTACACTAAGAAGA
  AATAAAATCCATGATGGAAGAGATGGTGGCATCTGTATATTTAATGGGGGTCGAGGTCTC
  CTTGAAGAAAATGATATTTTCAGGAATGCTCAAGCAGGTGTTCTCATCAGCACTAATAGT
  CATCCAATCTTAAGGAAAAACAGAATATTTGATGGATTTGCCGCAGGTATTGAAATTACA
  AATCACGCAACTGCAACACTAGAAGGCAATCAGATTTTTAACAACCGGTTTGGAGGCTTA
  TTTTTAGCATCTGGTGTTAATGTGACAATGAAAGATAACAAAATAATGAACAATCAAGAT
  GCCATAGAAAAGGCTGTTAGTAGAGGCCAATGTTTATATAAAATATCAAGTTATACCAGC
  TATCCCATGCATGATTTCTACAGATGTCATACTTGTAACACCACAGATCGAAATGCCATA
  TGTGTGAACTGCATTAAGAAGTGCCATCAGGGACATGATGTAGAGTTTATTAGACATGAT
  AGGTTTTTCTGTGACTGTGGTGCTGGAACACTGTCTAATCCTTGTACATTAGCTGGTGAG
  CCTACACATGATACAGATACACTATATGACTCTGCTCCACCTATAGAATCTAATACATTG
  CAGCACAACTGA
  
  Clone variation with respect to NM_025133.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_025133 unedited
  AGTATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGCAGGAGCGG
  ACAACGTCGGCGAGCGGGATGATGATGTGCCTGCAGATATGGTTGCAGAAGAATCAGGTC
  CTGGTGCACAAAATAGTCCATACCAACTTCGTAGAAAAACTCTTTTGCCGAAAAGAACAG
  CGTGTCCCACAAAGAACAGTATGGAGGGCGCCTCAACTTCAACTACAGAAAACTTTGGTC
  ATCGTGCAAAACGTGCAAGAGTGTCTGGAAAATCACAAGATCTATCAGCAGCACCTGCTG
  AACAGTATCTTCAGGAGAAACTGCCAGATGAAGTGGTTCTAAAAATCTTCTCTTACTTGC
  TGGAACAGGATCTTTGTAGAGCAGCTTGTGTATGTAAACGCTTCAGTGAACTTGCTAATG
  ATCCAATTTTGTGGAAACGATTATATATGGAAGTATTTGAATATACTCGCCCTATGATGC
  ATCCTGAACCTGGAAAATTCTACCAGATTAATCCAGAAGAGTATGAACATCCAAATCCCT
  GGAAAGAGAGTTTCCAGCAGTTGTATAAAGGTGCACATGTAAAGCCAGGATTTGCTGAAC
  ATTTCTACAGTAACCCTGCAAGATATAAAGGAAGAGAAAATATGTTGTATTATGATACTA
  TTGAAGATGCCCTTGGTGGGAGTACAAGANGCTCATTNTGATGGACTTATCTTTGTTCAT
  TCTGGGATATATACTGATGAATGGATATATATTGAATCTNNCATCACCATGATGGNTGCA
  GCACTGGNGAAGTGGCAGANAAGTTATAATTGAAACACTAAGATCAACCTTCGTTTTTAG
  GAAGGCTCTGAGAAGCTATGTTGGAATATACAATAAGGTTAACCTGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_025133 unedited
  CTTGGACCGCGGCCGCATCTAAATACGGTTTTTTTTTTTTTTTTTTATGATCTAATAAAC
  TTTATCTTTTTAAAAATGACCATTTTTCCATTTTCTTTCTAGGAAATTAAACCCTTTTAA
  TTCTTATCTACCTTCTACATAATGGTTATTGAATACTCCACAATATATTAAGTCTAGATG
  TTATGGTACATGCATACACTTTCAGGCTGTTTTATACCCACTGTCACCAATACACATAAA
  TGGGGGAGGAAAAGCTATGAAACTGTATAGGGCTGTATATATACTTGTCTCAGCTTAATG
  CAGGAAATTGGTTTAATTTCCAGCAGTTTTGTCTAAACTGTTCAAAAAAAAACTATGAAC
  AGAGTTCAAATACAGGACTGTTTGTTTTGAAGAGACTTTCTAAAGTGTACTTAAAACATA
  GTAGTTTTTTACCTTTCACAAAACTGAGTTACAAGAATACTTTTGTTTTACAGTGCATCC
  CTTCCTAGGAAGTCTCATTAAAACACTCACTTTTTCTAGGGGTGATTTTGAATGCTGCAC
  AGGGAAGGGAAGGAAATAATAGTCTTAACTTTTCTTAAAGGATACCAGAAACATTGCTGG
  ATATAATTTAAGATTAGAGCTTTCTCTTTCATAGAAAGAACGTACATACTGNGACATGAG
  TACAGTTACAGCAAGTCTAGGTGTGCTAACAAAACAGGGCACATTCAAGTACAGTAAGAT
  TCTACTTGAAATTAAAAACAAACTACATGAGATTAAAGCATTAAAATATATTTCTCAATC
  TGAATACATGTCTAAAAAAAAATCANAAGGAACGCAGAAGTGCTAGCTCACATTTTTACC
  ATATTACAAAAGCAATGGGTACCCATGTCCCATAAAGCAGCAACAAAGCTGCTTGTCTAT
  TGAGATACTACCGCANATTNACTGCCTTCATGCTCATTGTAAAACCCAGNCTTTCAGAGT
  GGTATCTGACCAAATGCAGTTATTTCTTCCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_025133
• ORF Size: 2532 bp
• Insert Size: 3800
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_025133.3, NP_079409.3
• RefSeq Size: 3951
• RefSeq ORF: 2532
• Locus ID: 80204
• Domains: PbH1, CASH
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
  Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.