Radixin (RDX) (NM_002906) Human Untagged Clone

CAT#: SC110995

RDX (untagged)-Human radixin (RDX)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RDX
• Synonyms: DFNB24
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110995 sequence for NM_002906 edited (data generated by NextGen Sequencing)
  ATGCCGAAACCAATCAACGTAAGAGTAACTACAATGGATGCTGAGCTGGAATTTGCCATT
  CAGCCCAATACAACTGGCAAACAACTTTTTGACCAGGTGGTGAAAACAGTTGGTTTGCGT
  GAGGTCTGGTTTTTTGGGCTGCAGTATGTAGACAGCAAAGGTTATTCTACATGGCTTAAA
  CTAAATAAAAAGGTAACACAGCAGGATGTTAAAAAAGAGAATCCTTTACAGTTCAAGTTT
  AGAGCTAAATTCTTTCCTGAAGATGTTTCTGAGGAATTAATTCAAGAAATAACCCAGAGA
  CTCTTCTTCTTGCAAGTTAAAGAAGCCATCTTAAATGATGAGATATATTGCCCGCCAGAA
  ACTGCAGTTCTTTTGGCTTCCTATGCTGTCCAAGCCAAGTATGGAGATTACAATAAAGAG
  ATTCATAAGCCAGGCTACCTGGCTAATGATAGACTCCTACCCCAGCGTGTATTGGAACAA
  CACAAACTAACAAAAGAACAGTGGGAAGAAAGAATACAGAACTGGCATGAAGAACATAGA
  GGAATGTTAAGGGAGGATTCTATGATGGAATACCTGAAGATTGCACAAGATCTAGAAATG
  TATGGAGTCAACTATTTTGAAATAAAAAATAAAAAAGGAACTGAATTGTGGCTAGGTGTT
  GATGCTTTGGGTCTGAATATTTATGAGCATGACGACAAGTTAACACCTAAAATTGGTTTT
  CCCTGGAGTGAAATCAGAAATATTTCATTTAATGACAAAAAATTTGTTATAAAGCCAATC
  GACAAAAAGGCACCTGATTTTGTGTTTTATGCACCTCGTCTGAGAATCAATAAGCGGATT
  TTGGCCTTATGTATGGGAAACCATGAACTATACATGCGAAGAAGGAAGCCTGATACTATT
  GAAGTACAACAGATGAAGGCTCAGGCTAGGGAGGAGAAACATCAGAAGCAGTTGGAAAGG
  GCACAATTAGAGAATGAAAAGAAGAAAAGAGAAATAGCAGAAAAGGAAAAGGAAAGAATA
  GAACGTGAAAAGGAAGAGCTAATGGAACGTCTAAAACAAATTGAAGAGCAGACAATTAAA
  GCTCAGAAAGAACTAGAAGAACAGACTCGAAAAGCTCTAGAACTGGATCAAGAACGAAAA
  CGAGCAAAAGAAGAAGCAGAACGACTTGAAAAGGAGCGTCGAGCTGCTGAAGAGGCAAAG
  TCTGCCATAGCAAAACAAGCTGCCGACCAGATGAAGAATCAGGAGCAGCTAGCAGCAGAA
  CTTGCTGAATTCACTGCCAAGATTGCACTTCTAGAGGAAGCCAAGAAGAAAAAGGAAGAG
  GAAGCTACTGAGTGGCAACACAAAGCTTTTGCAGCCCAGGAAGACTTGGAAAAGACCAAA
  GAAGAGTTAAAAACTGTGATGTCTGCCCCCCCTCCACCTCCACCACCACCAGTCATTCCT
  CCAACAGAAAACGAACATGATGAACACGATGAGAATAATGCTGAAGCTAGTGCTGAATTA
  TCAAATGAAGGGGTAATGAACCATAGAAGCGAGGAAGAACGTGTAACCGAAACACAGAAA
  AATGAGCGTGTTAAGAAGCAACTTCAGGCATTAAGTTCAGAATTAGCCCAAGCCAGAGAT
  GAAACCAAGAAAACACAAAATGATGTTCTTCATGCTGAGAATGTTAAAGCAGGCCGTGAT
  AAGTACAAGACTCTGCGACAGATTCGACAAGGCAATACAAAGCAGCGTATCGATGAGTTT
  GAAGCAATGTGA
  
  Clone variation with respect to NM_002906.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002906 unedited
  TGTCAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGCGGAGGCGCC
  GAGCGGCCATATTGCGGAGCTGTCTGCGGTGGCGGCGGCGCCTCTCGTCTCCCGCGGCCC
  AGCGCTCGCACCACCGCTTCTCCCTCCCTGTCGCAGCCGCGCCGCCGCGCAGCGCCCCAG
  CCACACGCCGGCGGGCAGAAGCCGCCCGCTCTCCGGAAAGTGATAACAGAATTCATTGAA
  GTGGAGAATTTTTAAAGAAGGTAACAAAAAGAGAAAGAAAATGCCGAAACCAATCAACGT
  AAGAGTAACTACAATGGATGCTGAGCTGGAATTTGCCATTCAGCCCAATACAACTGGCAA
  ACAACTTTTTGACCAGGTGGTGAAAACAGTTGGTTTGCGTGAGGTCTGGTTTTTTGGGCT
  GCAGTATGTAGACAGCAAAGGTTATTCTACATGGCTTAAACTAAATAAAAAGGTAACACA
  GCAGGATGTTAAAAAAGAGAATCCTTTACAGTTCAAGTTTAGAGCTAAATTCTTTCCTGA
  AGATGTTTCTGAGGAATTAATTCAAGAAATAACCCAGAGACTCTTCTTCTTGCAAGTTAA
  AGAAGCCATCTTAAATGATGAGATATATTGCCCGCCAGAAACTGCAGTTCTTTTGGCTTC
  CTATGCTGTCCAAGCCAAGTATGGAGATTACCATAAAGAGATTCATAAGCCAGGCTACCT
  GGCTAATGATAGACTCCTACCCCAGCGTGTATTGGAACACACAAACTAACANAAGACAGT
  GGGAAGAAGATACAGACTGGCATGAAGACATAGAGGATGTTANGGGGAGATCATGATGGN
  ATACCTGAGATGCCCAGATCTAAAAGTATGGAGCAACTATTTGGAATAAAAATAAAAGGA
  ACTGATGTGCTAGTNGTGAGCTTGGGTCTGATATTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002906 unedited
  TGTACGCGGCCGCATCTATAGTCGGTTTTTTTTTTTTTTTTTTTTGCATGAGCTTTTGTC
  ACTTTATTGTTAACCAATGAATATTATCCAAAATTAGAGATGTAATTGTAACTTAATTGT
  ACAACACAAAATTATGCTAATGGTAAAAGCCTACTGGGATTTACCAAATACTCATTAGTG
  TATTTTTACATTGACTATATGAACATGTGCTCGCGACTGCTAATAAGTTATAATTGGTTT
  AATCTCTAAAAAATCCATATTGCAAATGGTTCTTGTTTAAAAAAATTCACACAGCCTTAA
  AAATGGATTAAATCCATTTTAATCCTAATCTACAAATAGATCATAAACAGCAAAATATAA
  CTGATAATTTTTCAATACTGTATCAAACTGATGTAGCTATGGTAGTGCACATAATTCAAA
  ATGAGGAAAATTAACAAAAATCCAATGAAAGTTCAGGTTTTTATCTATTATGCAATTGCT
  TTAAAGTGAACATTTATGTCTCAAAACATGAATAGTACGGTCCACCATCCATTCCTTTGA
  TGTACTGCAAGCAGGAATATTCTCTTCATTGGATTCTGAATCTTGTGTACAACCCTGGCA
  CATCATTACTTCAAGGGTTATCTCCTTGTTTTTGCTCCTCCAGCTCCCTGTTTTCTTTTT
  TTGTTTTTTGTTTTTTTTTCGTGTTTGGTTCTGTTGTTTTTTTTTTTTTTTTCCTTTTTT
  TTTTGGTGTTTGTTGTTTCTTATTTTTTTTTTGCTTTTTTGTAGTGTTTGTGTGAGGGTA
  TNTTTCGTGTTTTGTTCTGGGCTTCCATTTTCGGCGTGGTCTTGCTCAGGTTGNTCTGCT
  GTTACCCCGTGGTGCATGTGTGTGTGTTTCCCATGTGATACTTCACGCCAATGGGCTGTA
  TGCCCGTGCTGGTTATTGCTAACACTTGTCGAAGCTTATTCTTCACCATATTACTCTCCT
  CTTATTTTTCTATATCCTCCTCTCCTA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002906
• Insert Size: 4730 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002906.3, NP_002897.1
• RefSeq Size: 4498 bp
• RefSeq ORF: 1752 bp
• Locus ID: 5962
• Cytogenetics: 11q22.3
• Domains: B41, ERM
• Protein Families: Druggable Genome
• Protein Pathways: Regulation of actin cytoskeleton
• Gene Summary: 'Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]'
  Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter C-terminus, compared to isoform 1.