Radixin (RDX) (NM_002906) Human Untagged Clone

CAT#: SC322155

RDX (untagged)-Human radixin (RDX)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RDX
• Synonyms: DFNB24
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002906 edited
  ATTGCGGAGCTGTCTGCGGTGGCGGCGGCGCCTCTCGTCTCCCGCGGCCCAGCGCTCGCA
  CCACCGCTTCTCCCTCCCTGTCGCAGCCGCGCCGCCGCGCAGCGCCCCAGCCACACGCCG
  GCGGGCAGAAGCCGCCCGCTCTCCGGAAAGTGATAACAGAATTCATTGAAGTGGAGAATT
  TTTAAAGAAGGTAACAAAAAGAGAAAGAAAATGCCGAAACCAATCAACGTAAGAGTAACT
  ACAATGGATGCTGAGCTGGAATTTGCCATTCAGCCCAATACAACTGGCAAACAACTTTTT
  GACCAGGTGGTGAAAACAGTTGGTTTGCGTGAGGTCTGGTTTTTTGGGCTGCAGTATGTA
  GACAGCAAAGGTTATTCTACATGGCTTAAACTAAATAAAAAGGTAACACAGCAGGATGTT
  AAAAAAGAGAATCCTTTACAGTTCAAGTTTAGAGCTAAATTCTTTCCTGAAGATGTTTCT
  GAGGAATTAATTCAAGAAATAACCCAGAGACTCTTCTTCTTGCAAGTTAAAGAAGCCATC
  TTAAATGATGAGATATATTGCCCGCCAGAAACTGCAGTTCTTTTGGCTTCCTATGCTGTC
  CAAGCCAAGTATGGAGATTACAATAAAGAGATTCATAAGCCAGGCTACCTGGCTAATGAT
  AGACTCCTACCCCAGCGTGTATTGGAACAACACAAACTAACAAAAGAACAGTGGGAAGAA
  AGAATACAGAACTGGCATGAAGAACATAGAGGAATGTTAAGGGAGGATTCTATGATGGAA
  TACCTGAAGATTGCACAAGATCTAGAAATGTATGGAGTCAACTATTTTGAAATAAAAAAT
  AAAAAAGGAACTGAATTGTGGCTAGGTGTTGATGCTTTGGGTCTGAATATTTATGAGCAT
  GACGACAAGTTAACACCTAAAATTGGTTTTCCCTGGAGTGAAATCAGAAATATTTCATTT
  AATGACAAAAAATTTGTTATAAAGCCAATCGACAAAAAGGCACCTGATTTTGTGTTTTAT
  GCACCTCGTCTGAGAATCAATAAGAGGATTTTGGCCTTATGTATGGGAAACCATGAACTA
  TACATGCGAAGAAGGAAGCCTGATACTATTGAAGTACAACAGATGAAGGCTCAGGCTAGG
  GAGGAGAAACATCAGAAGCAGTTGGAAAGGGCACAATTAGAGAATGAAAAGGAGAAAAGA
  GAAATAGCAGAAAAGGAAAAGGAAAGAATAGAACGTGAAAAGGAAGAGCTAATGGAACGT
  CTAAAACAAATTGAAGAGCAGACAATTAAAGCTCAGAAAGAACTAGAAGAACAGACTCGA
  AAAGCTCTAGAACTGGATCAAGAACGAAAACGAGCAAAAGAAGAAGCAGAACGACTTGAA
  AAGGAGCGTCGAGCTGCTGAAGAGGCAAAGTCTGCCATAGCAAAACAAGCTGCCGACCAG
  ATGAAGAATCAGGAGCAGCTAGCAGCAGAACTTGCTGAATTCACTGCCAAGATTGCACTT
  CTAGAGGAAGCCAAGAAGAAAAAGGAAGAGGAAGCTACTGAGTGGCAACACAAAGCTTTT
  GCAGCCCAGGAAGACTTGGAAAAGACCAAAGAAGAGTTAAAAACTGTGATGTCTGCCCCC
  CCTCCACCTCCACCACCACCAGTCATTCCTCCAACAGAAAACGAACATGATGAACACGAT
  GAGAATAATGCTGAAGCTAGTGCTGAATTATCAAATGAAGGGGTAATGAACCATAGAAGC
  GAGGAAGAACGTGTAACCGAAACACAGAAAAATGAGCGTGTTAAGAAGCAACTTCAGGCA
  TTAAGTTCAGAATTAGCCCAAGCCAGAGATGAAACCAAGAAAACACAAAATGATGTTCTT
  CATGCTGAGAATGTTAAAGCAGGCCGTGATAAGTACAAGACTCTGCGACAGATTCGACAA
  GGCAATACAAAGCAGCGTATCGATGAGTTTGAAGCAATGTGAGAGCTGTTATTTTGCATA
  TATGTTCTTCATAAGCTGAACCACCAACAGAGAAAAGCAGGCCTTTGCAGATATGATGGA
  ATGCATCCCACCTTGCCAAAGCACTTACACCAGTTTGACTGTGCTAGCTAAAAGACAAAT
  TTAAGGGGAGCTCTTCAACATTAAGGCAGTATGATATCATGCTTGGTTTTCTTTTTTCTT
  TTGGTCCAGGGAATGGAGAATGGTGTTCCATTGCCTCTTTTCACATTTTTTTTCTTTTTC
  TTTTTTTTTTCTGTTGAAGATTAACACTAATTATCACGTCTGACAAATGTGTATGTGTGG
  TTTCAGTTCTGTGTACATTTTAAAGGATAATGGTGAACATTTTAATGGGTTTCCCTTGCC
  CTTTCCATATTTAACCTATTTCCACATTCTCTCTCACTCACATTTTCTCAGTGTGCCCTT
  CTCTTATCTGCCGTGTCCATAGCCATAATTCCACCATCATACAGATCAGGCAGTGTTTAA
  AATGATGGTAGGTAGCACAGTGGACAGTCTTTGATCATCATGTAGAATATGGCTATGAAT
  CAGGAAAGAGATTAGAACATTTAATAATGTATGTACAGCTGGTGCTTAGTTTTTTTTTAA
  TCTAAATTTAATTACCTTATTGGATATTTGATATTTGGTTATTTAATCACAGTCATCTTT
  AACAGCTTACACTGATTGGTGTTTTATCTCCTGTGATCCTTTGATGGCTTTTTTTGCCTA
  CCATTTCACAGAGGTTTAGACAGCAGTAGTAGCTCCCTAGGAGAGTTTACTGATGAAACA
  GCCTCTGCAAGATTTTAAAAGTTTTGTTCTTTTATAGACTGATTTAGAAAAACAAATGAT
  TAGTTAAAAAAAGAAAATATACATTTGTTGGTAACTAATGTTATTTTTTAAAACCTGGAC
  C:TTTCTGGAAGGGCAGCATATAAAAACATCAGTCCCGAGGAGGGGACAACAATACTACC
  TCACTACTACATCTGTGATGACTGGTTGTTCAAACACAATGGAGTGTGTAAGGTATATGT
  TTTATAATTCATAACCATAGCCTCGATCATCAAGAAATACTTTCGAAATTTCATTTTCCT
  TCAGAATATCTTAAGAGTGCTAAATTTTTAACTGCCTTTTTGTCGAGTCAAACTGTGGGA
  TTCTGATTTGTATTAAAATTGTAAGCTCCTCACTGGTATACTATCATCCTGGAGGGGTGT
  TGTATGGCTGAGCAAGAGAGAGAGAGAATGAGAGAGAGACTGTGTGTGTGTGTGTGTGTG
  TGTGT:::ACT:CTGTGTGTGTATGAGAGAGAGAGAGAAATGCTAACCTTGTAGCATGTG
  AAGAATGTCTGTACCTTGATACGATAGTTACATAATCAGTATATTTGGTTTCTAGATCAC
  TGTGCTTATTTTGTTTCAATCTCTGACTAAAAATACTTAAATTTGGTTTGTTAATTCTTA
  TTTTAGAAATTATAATTTTAGTTTATATTAATTTCGGTTATAGCTTACTGAAGAAATCTT
  TCCAGTTAGAAGGAGGTTCTAATATTCACATGTTCTAATACTTTGTTTATTGTAAAACAG
  CTAAATTTGGAGATACGTAAAGCCTTGTTTTCTCTGTGTGGTTCAGCTACTTTCCATTTG
  GTATTACACAGTCAAATTTACATTTATCTATTAAAATTGCCATTTTATTAAACATTTTCA
  TGCACAGTAGATTCAAGTTGTGTCTGAAAATATCTCTTGTGCTTTTTTGATTTTGCTGAC
  TTTAAAAGGATTAATCTGGGCAGACATTATGTAAAAGAAAGGTTGCGTTTAATATATTTT
  TTGAACTTTGTAGGACAAAACATAGCTGGTTAACCTTGAAGTGACTGTTGTACCATGGTT
  GTGCACATGCTTCAGAATCCTATGGAAGAGAATATTCCTACTTGCAGTACATCAAAGGAA
  TGGATGGTGGACCCTACTATTCATGTTTTGAGACATAAATGTTCACTTTAAAGCAATTGC
  ATAATAGATAAAAACCTGAACTTTCATTGGATTTTTGTTAATTTTCCTCATTTTGAATTA
  TGTGCACTACCATAGCTACATCAGTTTGATACAGTATTGAAAAATTATCAGTTATATTTT
  GCTGTTTATGATCTATTTGTAGATTAGGATTAAAATGGATTTAATCCATTTTTAAGGCTG
  TGTGAATTTTTCTAAACAAGAACCATTTGCAATATGGATTTCTTAGAGATTAAACCAATT
  ATAACTTATTAGCAGTCGCGAGCACATGTTCATATAGTCAATGTAAAAATACACTAATGA
  GTATTTGGTAAATCCCAGTAGGCTTTTACCATTAGCATAATTTTGTGTTGTACAATTAAG
  TTACAATTACATCTCTAATTTTGGATAATATTCATTGGTTAACAATAAAGTGACAAAAGC
  TCAAAAAAAAAAAAAAAAAAGAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_002906
• Insert Size: 4400 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002906.3, NP_002897.1
• RefSeq Size: 4498 bp
• RefSeq ORF: 1752 bp
• Locus ID: 5962
• Cytogenetics: 11q22.3
• Domains: B41, ERM
• Protein Families: Druggable Genome
• Protein Pathways: Regulation of actin cytoskeleton
• Gene Summary: 'Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]'
  Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter C-terminus, compared to isoform 1.