DR5 (TNFRSF10B) (NM_003842) Human Untagged Clone

CAT#: SC111085

TNFRSF10B (untagged)-Human tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1


  "NM_003842" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TNFRSF10B
Synonyms CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_003842 edited
GCGCTTGCGGAGGATTGCGTTGACGAGACTCTTATTTATTGTCACCAACCTGTGGTGGAA
TTTGCAGTTGCACATTGGATCTGATTCGCCCCGCCCCGAATGACGCCTGCCCGGAGGCAG
TGAAAGTACAGCCGCGCCGCCCCAAGTCAGCCTGGACACATAAATCAGCACGCGGCCGGA
GAACCCCGCAATCTCTGCGCCCACAAAATACACCGACGATGCCCGATCTACTTTAAGGGC
TGAAACCCACGGGCCTGAGAGACTATAAGAGCGTTCCCTACCGCCATGGAACAACGGGGA
CAGAACGCCCCGGCCGCTTCGGGGGCCCGGAAAAGGCACGGCCCAGGACCCAGGGAGGCG
CGGGGAGCCAGGCCTGGGCTCCGGGTCCCCAAGACCCTTGTGCTCGTTGTCGCCGCGGTC
CTGCTGTTGGTCTCAGCTGAGTCTGCTCTGATCACCCAACAAGACCTAGCTCCCCAGCAG
AGAGCGGCCCCACAACAAAAGAGGTCCAGCCCCTCAGAGGGATTGTGTCCACCTGGACAC
CATATCTCAGAAGACGGTAGAGATTGCATCTCCTGCAAATATGGACAGGACTATAGCACT
CACTGGAATGACCTCCTTTTCTGCTTGCGCTGCACCAGGTGTGATTCAGGTGAAGTGGAG
CTAAGTCCCTGCACCACGACCAGAAACACAGTGTGTCAGTGCGAAGAAGGCACCTTCCGG
GAAGAAGATTCTCCTGAGATGTGCCGGAAGTGCCGCACAGGGTGTCCCAGAGGGATGGTC
AAGGTCGGTGATTGTACACCCTGGAGTGACATCGAATGTGTCCACAAAGAATCAGGTACA
AAGCACAGTGGGGAAGCCCCAGCTGTGGAGGAGACGGTGACCTCCAGCCCAGGGACTCCT
GCCTCTCCCTGTTCTCTCTCAGGCATCATCATAGGAGTCACAGTTGCAGCCGTAGTCTTG
ATTGTGGCTGTGTTTGTTTGCAAGTCTTTACTGTGGAAGAAAGTCCTTCCTTACCTGAAA
GGCATCTGCTCAGGTGGTGGTGGGGACCCTGAGCGTGTGGACAGAAGCTCACAACGACCT
GGGGCTGAGGACAATGTCCTCAATGAGATCGTGAGTATCTTGCAGCCCACCCAGGTCCCT
GAGCAGGAAATGGAAGTCCAGGAGCCAGCAGAGCCAACAGGTGTCAACATGTTGTCCCCC
GGGGAGTCAGAGCATCTGCTGGAACCGGCAGAAGCTGAAAGGTCTCAGAGGAGGAGGCTG
CTGGTTCCAGCAAATGAAGGTGATCCCACTGAGACTCTGAGACAGTGCTTCGATGACTTT
GCAGACTTGGTGCCCTTTGACTCCTGGGAGCCGCTCATGAGGAAGTTGGGCCTCATGGAC
AATGAGATAAAGGTGGCTAAAGCTGAGGCAGCGGGCCACAGGGACACCTTGTACACGATG
CTGATAAAGTGGGTCAACAAAACCGGGCGAGATGCCTCTGTCCACACCCTGCTGGATGCC
TTGGAGACGCTGGGAGAGAGACTTGCCAAGCAGAAGATTGAGGACCACTTGTTGAGCTCT
GGAAAGTTCATGTATCTAGAAGGTAATGCAGACTCTGCCATGTCCTAAGTGTGATTCTCT
TCAGGAAGTCAGACCTTCCCTGGTTTACCTTTTTTCTGGAAAAAGCCCAACTGGACTCCA
GTCAGTAGGAAAGTGCCACAATTGTCACATGACCGGTACTGGAAGAAACTCTCCCATCCA
ACATCACCCAGTGGATGGAACATCCTGTAACTTTTCACTGCACTTGGCATTATTTTTATA
AGCTGAATGTGATAATAAGGACACTATGGAAATGTCTGGATCATTCCGTTTGTGCGTACT
TTGAGATTTGGTTTGGGATGTCATTGTTTTCACAGCACTTTTTTATCCTAATGTAAATGC
TTTATTTATTTATTTGGGCTACATTGTAAGATCCATCTACACAGTCGTTGTCCGACTTCA
CTTGATACTATATGATATGAACCTTTTTTGGGTGGGGGGTGCGGGGCAGTTCACTCTGTC
TCCCAGGCTGGAGTGCAATGGTGCAATCTTGGCTCACTATAGCCTTGACCTCTCAGGCTC
AAGCGATTCTCCCACCTCAGCCATCCAAATAGCTGGGACCACAGGTGTGCACCACCACGC
CCGGCTAATTTTTTGTATTTTGTCTAGATATAGGGGCTCTCTATGTTGCTCAGGGTGGTC
TCGAATTCCTGGACTCAAGCAGTCTGCCCACCTCAGACTCCCAAAGCGGTGGAATTAGAG
GCGTGAGCCCCCATGCTTGGCCTTACCTTTCTACTTTTATAATTCTGTATGTTATTATTT
TATGAACATGAAGAAACTTTAGTAAATGTACTTGTTTACATAGTTATGTGAATAGATTAG
ATAAACATAAAAGGAGGAGACATACAATGGGGGAAGAAGAAGAAGTCCCCTGTAAGATGT
CACTGTCTGGGTTCCAGCCCTCCCTCAGATGTACTTTGGCTTCAATGATTGGCAACTTCT
ACAGGGGCCAGTCTTTTGAACTGGACAACCTTACAAGTATATGAGTATTATTTATAGGTA
GTTGTTTACATATGAGTCGGGACCAAAGAGAACTGGATCCACGTGAAGTCCTGTGTGTGG
CTGGTCCCTACCTGGGCAGTCTCATTTGCACCCATAGCCCCCATCTATGGACAGGCTGGG
ACAGAGGCAGATGGGTTAGATCACACATAACAATAGGGTCTATGTCATATCCCAAGTGAA
CTTGAGCCCTGTTTGGGCTCAGGAGATAGAAGACAAAATCTGTCTCCCACGTCTGCCATG
GCATCAAGGGGGAAGAGTAGATGGTGCTTGAGAATGGTGTGAAATGGTTGCCATCTCAGG
AGTAGATGGCCCGGCTCACTTCTGGTTATCTGTCACCCTGAGCCCATGAGCTGCCTTTTA
GGGTACAGATTGCCTACTTGAGGACCTTGGCCGCTCTGTAAGCATCTGACTCATCTCAGA
AATGTCAATTCTTAAACACTGTGGCAACAGGACCTAGAATGGCTGACGCATTAAGGTTTT
CTTCTTGTGTCCTGTTCTATTATTGTTTTAAGACCTCAGTAACCATTTCAGCCTCTTTCC
AGCAAACCCTTCTCCATAGTATTTCAGTCATGGAAGGATCATTTATGCAGGTAGTCATTC
CAGGAGTTTTTGGTCTTTTCTGTCTCAAGGCATTGTGTGTTTTGTTCCGGGACTGGTTTG
GGTGGGACAAAGTTAGAATTGCCTGAAGATCACACATTCAGACTGTTGTGTCTGTGGAGT
TTTAGGAGTGGGGGGTGACCTTTCTGGTCTTTGCACTTCCATCCTCTCCCACTTCCATCT
GGCATCCCACGCGTTGTCCCCTGCACTTCTGGAAGGCACAGGGTGCTGCTGCCTCCTGGT
CTTTGCCTTTGCTGGGCCTTCTGTGCAGGACGCTCAGCCTCAGGGCTCAGAAGGTGCCAG
TCCGGTCCCAGGTCCCTTGTCCCTTCCACAGAGGCCTTCCTAGAAGATGCATCTAGAGTG
TCAGCCTTATCAGTGTTTAAGATTTTTCTTTTATTTTTAATTTTTTTGAGACAGAATCTC
ACTCTCTCGCCCAGGCTGGAGTGCAACGGTACGATCTTGGCTCAGTGCAACCTCCGCCTC
CTGGGTTCAAGCGATTCTCGTGCCTCAGCCTCCGGAGTAGCTGGGATTGCAGGCACCCGC
CACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAG
GCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTTGGCCTCCGAAAGTGCTGGGATTA
CAGGCGTGAGCCACCAGCCAGGCCAAGCTATTCTTTTAAAGTAAGCTTCCTGACGACATG
AAATAATTGGGGGTTTTGTTGTTTAGTTACATTAGGCTTTGCTATATCCCCAGGCCAAAT
AGCATGTGACACAGGACAGCCATAGTATAGTGTGTCACTCGTGGTTGGTGTCCTTTCATG
CTTCTGCCCTGTCAAAGGTCCCTATTTGAAATGTGTTATAATACAAACAAGGAAGCACAT
TGTGTACAAAATACTTATGTATTTATGAATCCATGACCAAATTAAATATGAAACCTTATA
TAAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_003842 unedited
CCCCGCCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA
GCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT
TCGGCACGAGGCATAAATCAGCACGCGGCCGGAGAACCCCGCAATCTCTGCGCCCACAAA
ATACACCGACGATGCCCGATCTACTTTAAGGGCTGAAACCCACGGGCCTGAGAGACTATA
AGAGCGTTCCCTACCGCCATGGAACAACGGGGACAGAACGCCCCGGCCGCTTCGGGGGCC
CGGAAAAGGCACGGCCCAGGACCCAGGGAGGCGCGGGGAGCCAGGCCTGGGCTCCGGGTC
CCCAAGACCCTTGTGCTCGTTGTCGCCGCGGTCCTGCTGTTGGTCTCAGCTGAGTCTGCT
CTGATCACCCAACAAGACCTAGCTCCCCAGCAGAGAGCGGCCCCACAACAAAAGAGGTCC
AGCCCCTCAGAGGGATTGTGTCCACCTGGACACCATATCTCAGAAGACGGTAGAGATTGC
ATCTCCTGCAAATATGGACAGGACTATAGCACTCACTGGAATGACCTCCTTTTCTGCTTG
CGCTGCACCAGGTGTGATTCAGGTGAAGTGGAGCTAAGTCCCTGCACCACGACCAGAAAC
ACAGTGTGTCAGTGCGAAGAAGGCACCTTCCGGGAAGAAAGATCTCCTGAGATGTGCCGG
AAGTGCCGCACAGGGTGTCCCAGAGGGATGGTCAGGGGTCGTGATGTACACCCTGGAGTG
CATCGAATGTGTCCACAAGAATCAGGTACCGCACAGTGGNGAGCCCCGCTGTGGAGAGAC
GGTGACTNCAGCCCAGGACTCTGCCTCTCCTGTTCCTCTCAGCATATCATAGAGTACAGT
GCAGCCGANCTGATGTGGCTGGGTTGTTGCAGTCTTATGTGGGAGAAGTCTTCTA
>OriGene 3' read for NM_003842 unedited
NGGTCCTGACTNTGNNACCGCGGCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTTTA
TATAAGGTTTCATATTTAATTTGGTCATGGATTCATAAATACATAAGTATTTTGTACACA
ATGTGCTTCCTTGTTTGTATTATAACACATTTCAAATAGGGACCTTTGACAGGGCAGAAG
CATGAAAGGACACCAACCACGAGTGACACACTATACTATGGCTGTCCTGTGTCACATGCT
ATTTGGCCTGGGGATATAGCAAAGCCTAATGTAACTAAACAACAAAACCCCCAATTATTT
CATGTCGTCAGGAAGCTTACTTTAAAAGAATAGCTTGGCCTGGCTGGTGGCTCACGCCTG
TAATCCCAGCACTTTCGGAGGCCAAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGC
CTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTG
GCGGGTGCCTGCAATCCCAGCTACTCCGGAGGCTGAGGCACGAGAATCGCTTGAACCCAG
GAGGCGGAGGTTGCACTGAGCCAAGATCGTACCGTTGCACTCCAGCCTGGGCGAGAGAGT
GAGATTCTGTCTCAAAAAAATTAAAAATAAAAGAAAAATCTTAAACACTGATAAGGCTGA
CACTCTAGATGCATCTTCTAGGAAGGCCTCTGTGGAAGGGACAAGGGACCTGGGACCGGA
CTGGCACCTTCTGAGCCCTGAGGCTGAGCGTCCTGCACAGAAGGCCCAGCAAAGGCANAG
ACCAGNAGGCAGCAGCACCCTGTGCCTTCCAGAGTGCAGGGGACAACGCGTGGGATGCCA
NATGGAANNTGGAGAGGATGGAAGTGCAAAGACCANNAAAGGTCACCCCNCACTTCTAAA
ACTNCACAGAACACACAGTCTGAAATGTGTGATCTTCAGC
Restriction Sites NotI-NotI     
ACCN NM_003842
ORF Size 1323 bp
Insert Size 4000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_003842.3, NP_003833.3
RefSeq Size 4160
RefSeq ORF 1323
Locus ID 8795
Domains DEATH, TNFR
Protein Families Druggable Genome, Transmembrane
Protein Pathways Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway
Gene Summary The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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