PAICS (NM_006452) Human Untagged Clone

CAT#: SC111158

PAICS (untagged)-Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAICS
• Synonyms: ADE2; ADE2H1; AIRC; PAIS
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111158 sequence for NM_006452 edited (data generated by NextGen Sequencing)
  ATGGCGACAGCTGAGGTACTGAACATTGGTAAAAAATTATATGAGGGTAAAACAAAAGAA
  GTCTACGAATTGTTAGACAGTCCAGGAAAAGTCCTCCTGCAGTCCAAGGACCAGATTACA
  GCAGGAAATGCAGCTAGAAAAAACCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATC
  ACCAGTTGTATTTTTCAGTTATTACAGGAAGCAGGTATTAAAACTGCCTTCACCAGAAAA
  TGTGGGGAGACAGCTTTCATTGCACCGCAGTGTGAAATGATTCCAATTGAATGGGTTTGC
  AGAAGAATAGCAACTGGTTCTTTTCTCAAAAGAAATCCTGGTGTCAAGGAAGGATATAAG
  TTTTACCCACCTAAAGTGGAGTTGTTTTTCAAGGATGATGCCAATAATGACCCACAGTGG
  TCTGAGGAACAGCTGATTGCTGCAAAATTTTGCTTTGCTGGACTTCTTATAGGCCAGACT
  GAAGTGGATATCATGAGTCATGCTACACAGGCTATATTTGAAATACTGGAGAAATCCTGG
  TTGCCCCAGAATTGTACACTGGTTGATATGAAGATTGAATTTGGTGTTGATGTAACCACC
  AAAGAAATTGTTCTTGCTGATGTTATTGACAATGATTCCTGGAGACTCTGGCCATCAGGA
  GATCGAAGCCAACAGAAAGACAAACAGTCTTATCGGGACCTCAAAGAAGTAACTCCTGAA
  GGGCTCCAAATGGTAAAGAAAAACTTTGAGTGGGTTGCAGAGAGAGTAGAGTTGCTTTTG
  AAATCAGAAAGTCAGTGCAGGGTTGTAGTGTTGATGGGCTCTACTTCTGATCTTGGTCAC
  TGTGAAAAAATCAAGAAGGCCTGTGGAAATTTTGGCATTCCATGTGAACTTCGAGTAACA
  TCTGCGCATAAAGGACCAGATGAAACTCTGAGGATTAAAGCTGAGTATGAAGGGGATGGC
  ATTCCTACTGTATTTGTGGCAGTGGCAGGCAGAAGTAATGGTTTGGGACCAGTGATGTCT
  GGGAACACTGCATATCCAGTTATCAGCTGTCCTCCCCTCACACCAGACTGGGGAGTTCAG
  GATGTGTGGTCTTCTCTTCGACTACCCAGTGGTCTTGGCTGTTCAACCGTACTTTCTCCA
  GAAGGATCAGCTCAATTTGCTGCTCAGATATTTGGGTTAAGCAACCATTTGGTATGGAGC
  AAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAATC
  AGAGAATGTAATTTATAA
  
  Clone variation with respect to NM_006452.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006452 unedited
  TTCAAATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGGTTCTGC
  CTCGCTTCCCGGCGCGGTCGCAGCCCTCAGCCCACTTAGGATAATGGCGACAGCTGAGGT
  ACTGAACATTGGTAAAAAATTATATGAGGGTAAAACAAAAGAAGTCTACGAATTGTTAGA
  CAGTCCAGGAAAAGTCCTCCTGCAGTCCAAGGACCAGATTACAGCAGGAAATGCAGCTAG
  AAAAAACCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATCACCAGTTGTATTTTTCA
  GTTATTACAGGAAGCAGGTATTAAAACTGCCTTCACCAGAAAATGTGGGGAGACAGCTTT
  CATTGCACCGCAGTGTGAAATGATTCCAATTGAATGGGTTTGCAGAAGAATAGCAACTGG
  TTCTTTTCTCAAAAGAAATCCTGGTGTCAAGGAAGGATATAAGTTTTACCCACCTAAAGT
  GGAGTTGTTTTTCAAGGATGATGCCAATAATGACCCACAGTGGTCTGAGGAACAGCTGAT
  TGCTGCAAAATTTTGCTTTGCTGGACTTCTTATAGGCCAGACTGAAGTGGATATCATGAG
  TCATGCTACACAGGCTATATTTGAAATACTGGAGAAATCCTGGTTGCCCCAGAATTGTAC
  ACTGGTTGATATGAAGATTGAATTTGGTGTNGATGNTACCACCAAAAGAATTNNGTCTGC
  TGNATGTATTTGACATGATTCCTGGAGACTCTGGCCATCAGGAGATCGAAGCCCNACAGA
  AGAACAACAGTCTTATCGGGACCTCAAAGAAGTACTCCCTGAGGGCNNTCAATGGNTAAG
  NAAAAACTTGAGTGGGTTGCANAGAGAGTAGAGTTGCTTTTTGAATCAGAAGTCANTGCA
  GGNTTGTANTGGTGAGGGCTCTACTTCTGATCTGGGTCACTGTGAAAAATCAGAAAGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006452 unedited
  ACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTATTCACTAATACA
  TTTTATTTGTGTTCTCTAATTTAAAATTACCTTTTCATCTTGCTTGATTTTCCTTCAGCT
  AAATTAGAAATTTGTAGTTTTTCCCCTAAAAAATTCAATGGCATTCTTTCTTATAAATTA
  CATTCTCTGATTTTCTTGTCAGCCTGCTTCAAGGAAATCCATGTGTTCAAAATGCTTGCT
  CGCAGTTTGCTCCATACCAAATGGTTGCTTAACCCAAATATCTGAGCAGCAAATTGAGCT
  GATCCTTCTGGAGAAAGTACGGTTGAACAGCCAAGACCACTGGGTAGTCGAAGAGAAGAC
  CACACATCCTGAACTCCCCAGTCTGGTGTGAGGGGAGGACAGCTGATAACTGGATATGCA
  GTGTTCCCAGACATCACTGGTCCCAAACCATTACTTCTGCCTGCCACTGCCACAAATACA
  GTAGGAATGCCATCCCCTTCATACTCAGCTTTAATCCTCAGAGTTTCATCTGGTCCTTTA
  TGCGCAGATGTTACTCGAAGTTCACATGGAATGCCAAAATTTCCACAGGCCTTCTTGATT
  TTTTCACAGTGACCAAGATCAGAAGTAGAGCCCATCAACACTACAACCCTGCACTGACTT
  TCTGATTTCAAAAGCAACTCTACTCTCTCTGCACCCACTCAAAGTTTTTCTTTACCATTT
  GGAGCCCTTCANGAGTTACTTCTTTGAGGTCCCGNATAGACTGTTTGTCTTTCTGTGGCC
  TTCGATCTCCTGATGGCCANAGTCTCCAGAAATCATTGTCAATAACATCAGCCAGAACAA
  TTTCTTTGGGTGGTACATCACACCAAATTCAATCTTCATATCAACCAGTGTACAATTCTG
  GGGCAACCAGGATTCTCCAGTATTNACAAATAGCCTGGTAACATGACTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006452
• ORF Size: 1278 bp
• Insert Size: 1500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006452.2, NP_006443.1
• RefSeq Size: 3322
• RefSeq ORF: 1278
• Locus ID: 10606
• Domains: AIRC, SAICAR_synt
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Purine metabolism
• Gene Summary: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the CDS, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.