WHIP (WRNIP1) (NM_020135) Human Untagged Clone

CAT#: SC111831

WRNIP1 (untagged)-Human Werner helicase interacting protein 1 (WRNIP1), transcript variant 1


  "NM_020135" in other vectors (5)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol WRNIP1
Synonyms bA420G6.2; WHIP
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_020135, the custom clone sequence may differ by one or more nucleotides


ATGGAGGTGAGCGGGCCGGAAGACGACCCCTTCCTTTCGCAGCTGCACCAGGTGCAGTGCCCCGTGTGCC
AGCAGATGATGCCCGCCGCGCACATCAACTCGCACCTGGACCGCTGTCTGCTGCTCCACCCGGCGGGGCA
CGCGGAGCCCGCGGCCGGGTCGCACCGCGCCGGGGAGCGGGCCAAGGGGCCCTCGCCGCCCGGCGCCAAG
AGGCGGCGGCTGTCGGAGAGCTCGGCGCTGAAGCAGCCAGCCACCCCGACGGCAGCCGAGAGCAGCGAGG
GCGAGGGTGAGGAGGGCGACGACGGCGGCGAGACCGAGAGCCGCGAGAGCTACGACGCGCCGCCCACACC
CAGCGGCGCCCGCCTTATCCCCGACTTCCCGGTGGCCCGCTCCAGCAGCCCCGGGAGGAAGGGGTCGGGG
AAGAGGCCGGCGGCCGCCGCCGCGGCGGGGAGCGCGTCTCCGCGCAGCTGGGACGAGGCGGAGGCGCAGG
AGGAGGAGGAGGCCGTGGGCGACGGCGATGGCGACGGGGACGCGGACGCGGACGGCGAGGACGACCCGGG
GCACTGGGACGCGGACGCTGCCGAAGCCGCCACCGCCTTCGGGGCCAGTGGCGGGGGCCGCCCGCACCCC
CGGGCGCTGGCTGCCGAGGAGATCCGACAGATGCTACAGGGCAAGCCGCTGGCCGACACGATGCGTCCTG
ACACGCTGCAGGATTACTTCGGGCAGAGCAAGGCCGTGGGCCAGGATACCCTGCTGCGCTCGCTCCTGGA
GACCAACGAAATCCCCTCGCTTATCCTGTGGGGGCCGCCGGGCTGCGGCAAGACCACTCTGGCTCACATC
ATAGCCAGCAACAGCAAGAAACATAGCATAAGGTTTGTGACATTATCTGCAACAAATGCCAAGACAAATG
ATGTGCGAGATGTCATAAAACAAGCTCAAAATGAAAAGAGCTTTTTCAAAAGGAAAACCATCCTTTTTAT
TGATGAGATTCATCGGTTCAATAAATCTCAGCAGGACACTTTCCTTCCTCACGTGGAATGTGGGACGATC
ACTCTGATTGGGGCAACCACTGAAAACCCTTCCTTCCAGGTCAACGCTGCTCTTCTGAGCCGCTGTCGAG
TGATTGTTCTTGAGAAGCTTCCAGTAGAGGCAATGGTGACTATTTTAATGCGAGCGATCAACTCCCTGGG
AATCCACGTCCTAGACTCTAGCCGTCCCACTGACCCTCTGAGCCACAGCAGCAACAGCAGCTCAGAGCCC
GCCATGTTCATAGAGGATAAAGCAGTAGACACCCTGGCTTACCTCAGTGACGGTGACGCCCGAGCTGGGT
TGAACGGACTGCAGCTGGCGGTGCTGGCTAGGTTAAGCTCTAGGAAGATGTTCTGTAAGAAGAGTGGGCA
ATCCTATTCTCCCAGTAGAGTTCTGATCACAGAGAATGACGTGAAGGAGGGCCTACAGCGATCCCACATT
TTATATGACCGGGCAGGTGAGGAGCATTACAACTGCATCTCCGCCCTGCACAAGTCCATGCGGGGCTCAG
ACCAGAACGCCTCCCTCTACTGGCTGGCTCGCATGCTCGAGGGAGGAGAGGACCCACTCTACGTGGCACG
GAGGCTTGTCAGGTTTGCCAGCGAGGACATAGGTCTGGCAGACCCGTCTGCGTTAACACAAGCGGTTGCT
GCCTACCAAGGCTGTCATTTTATAGGCATGCCTGAATGTGAGGTGCTTCTGGCCCAGTGTGTGGTCTACT
TTGCCAGAGCCCCAAAGTCCATTGAGGTGTACAGCGCCTACAACAACGTCAAAGCCTGCCTGAGGAACCA
CCAGGGGCCACTGCCCCCCGTGCCCCTGCACCTGAGGAACGCGCCCACTAGGCTGATGAAGGATTTGGGC
TATGGCAAAGGCTACAAGTACAACCCCATGTACAGCGAGCCTGTGGATCAGGAGTACCTGCCTGAAGAGT
TGAGGGGGGTAGATTTCTTCAAGCAGAGGAGGTGCTGA


>OriGene 5' read for NM_020135 unedited
NNNTTGTCAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGGANA
GAGAGAACTAGGCCGTGGGCGACGGCGATGGCGACGGGGACGCGGACGCGGACGGCGAGG
ACGACCCGGGGCACTGGGACGCGGACGCTGCCGAAGCCGCCACCGCCTTCGGGGCCAGTG
GCGGGGGCCGCCCGCACCCCCGGGCGCTGGCTGCCGAGGAGATCCGACAGATGCTACAGG
GCAAGCCGCTGGCCGACACGATGCGTCCTGACACGCTGCAGGATTACTTCGGGCAGAGCA
AGGCCGTGGGCCAGGATACCCTGCTGCGCTCGCTCCTGGAGACCAACGAAATCCCCTCGC
TTATCCTGTGGGGGCCGCCGGGCTGCGGCAAGACCACTCTGGCTCACATCATAGCCAGCA
ACAGCAAGAAACATAGCATAAGGTTTGTGACATTATCTGCAACAAATGCCAAGACAAATG
ATGTGCGAGATGTCATAAAACAAGCTCAAAATGAAAAGAGCTTTTTCAAAAGGAAAACCA
TCCTTTTTATTGATGAGATTCATCGGTTCAATAAATCTCAGCAGGACACTTTCCTTCCTC
ACGTGGAATGTGGGACGATCACTCTGATTGGGGCAACCACTGAAAACCCTTCCTTCCAGG
TCAACGCTGCTCTTCTGAGCCGCTGTCGAGTGATTGTTCTTGAGAAGCTTCCAGTAGAGG
CAATGGTGACTATNTTAATGCGAGCGATCAACTCCCTGGGAATCCACGTCCTAGACTCTA
GCCGTCCCACTGACCCTCTGAGCCCAGCAGCAACAGCAGCTCAGACCCGCCATGTCATAG
AGATAAAGCAGTGACACCTGGCTTACTCANTGACGGTGACCCCGANCTGGNNTGACGACT
G
>OriGene 3' read for NM_020135 unedited
TGTACGCGGCCGCAATCTAGTGTCGAGTTTTTTTTTTTTTTTTTTTACTTTGAAATAGTT
TTATTGGCTCGTAAGACCTTTGCATATAAAAAAATACCCAAAACACTATGCAGTATTAAA
TCACAATTACATTTTTTTACCAATTAAAACTACCCAGAATATACATTTTTTAAAGAAAAG
AAAATCCTACAGAACTGAATTCTGAAATGACATTATGACTTAAATACTATGACAAAATAG
ATAATTCCTTATAACATTAATTCATTGCACAAAGCTGCCAGGTATTTTCATAAGCATAAC
CGCTGCACCGAGTGCAAATGAACACAATTTCAAAGTTACACATTTATTCGAAAGAACTGC
GCCTCCACCTATGGAACTCTTAAATTTCTGGCACAAAATGTTGGTCTGTTCTAACTTCCA
CCAGGCAACCAACTTTGCAATCCACTAACTTTCTTTCTGGCCCTCCCTTAAAAAAGCAAC
ATCCTTCTGCTGTCGTGCCCTGAGGAGTCAGCACCTCCTCTGCTTGAAGAAATCTACCCC
CCTCAACTCTTCAGGCAGGTACTCCTGATCCACAGGCTCGCTGTACATGGGGTTGTACTT
GTAGCCTTTGCCATAGCCCAAATCCTTCATCAGCCTAGTGGGCGCGTTCCTCAGGTGCAG
GGGCACGGGGGGCAGTGGCCCCTGGTGGTTCCTCAGGCAGGCTTTGACGTTGTTGTAGGC
GCTGTACACCTCAATGGACTTTGGGGCTCTGGCAATGTAGACACACACTGGGCCAGAAGC
ACCTCACATTCAGGCATGCCTATAAATGACAGCCTTGGGTAGCAGNCACCGCTTGTGTTA
CGCANACGGGTCTGCCAGACCTATGTNCTCGCTGGNNCAACCTGACAGCCTNCGTGCACG
TAAAAGTGGGTCCTCTNCTNCCTCGAGCTGCGACCANCCATAAGGGGAAGGGTTCTGGTC
TGAACCCCCTGTACTGGGCAAGCCGAGTATTCATTGTATGCTCTCA
Restriction Sites NotI-NotI     
ACCN NM_020135
ORF Size 2670 bp
Insert Size 2000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_020135.1, NP_064520.1
RefSeq Size 2670
RefSeq ORF 2670
Locus ID 56897
Domains AAA, AAA, ZnF_Rad18
Gene Summary Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Transcript Variant: This variant (1) encodes the longer isoform (1).

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