WHIP (WRNIP1) (NM_020135) Human Untagged Clone

CAT#: SC318132

WRNIP1 (untagged)-Human Werner helicase interacting protein 1 (WRNIP1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: WRNIP1
• Synonyms: bA420G6.2; WHIP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_020135, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGGTGAGCGGGCCGGAAGACGACCCCTTCCTTTCGCAGCTGCACCAGGTGCAGTGCCCCGTGTGCC
  AGCAGATGATGCCCGCCGCGCACATCAACTCGCACCTGGACCGCTGTCTGCTGCTCCACCCGGCGGGGCA
  CGCGGAGCCCGCGGCCGGGTCGCACCGCGCCGGGGAGCGGGCCAAGGGGCCCTCGCCGCCCGGCGCCAAG
  AGGCGGCGGCTGTCGGAGAGCTCGGCGCTGAAGCAGCCAGCCACCCCGACGGCAGCCGAGAGCAGCGAGG
  GCGAGGGTGAGGAGGGCGACGACGGCGGCGAGACCGAGAGCCGCGAGAGCTACGACGCGCCGCCCACACC
  CAGCGGCGCCCGCCTTATCCCCGACTTCCCGGTGGCCCGCTCCAGCAGCCCCGGGAGGAAGGGGTCGGGG
  AAGAGGCCGGCGGCCGCCGCCGCGGCGGGGAGCGCGTCTCCGCGCAGCTGGGACGAGGCGGAGGCGCAGG
  AGGAGGAGGAGGCCGTGGGCGACGGCGATGGCGACGGGGACGCGGACGCGGACGGCGAGGACGACCCGGG
  GCACTGGGACGCGGACGCTGCCGAAGCCGCCACCGCCTTCGGGGCCAGTGGCGGGGGCCGCCCGCACCCC
  CGGGCGCTGGCTGCCGAGGAGATCCGACAGATGCTACAGGGCAAGCCGCTGGCCGACACGATGCGTCCTG
  ACACGCTGCAGGATTACTTCGGGCAGAGCAAGGCCGTGGGCCAGGATACCCTGCTGCGCTCGCTCCTGGA
  GACCAACGAAATCCCCTCGCTTATCCTGTGGGGGCCGCCGGGCTGCGGCAAGACCACTCTGGCTCACATC
  ATAGCCAGCAACAGCAAGAAACATAGCATAAGGTTTGTGACATTATCTGCAACAAATGCCAAGACAAATG
  ATGTGCGAGATGTCATAAAACAAGCTCAAAATGAAAAGAGCTTTTTCAAAAGGAAAACCATCCTTTTTAT
  TGATGAGATTCATCGGTTCAATAAATCTCAGCAGGACACTTTCCTTCCTCACGTGGAATGTGGGACGATC
  ACTCTGATTGGGGCAACCACTGAAAACCCTTCCTTCCAGGTCAACGCTGCTCTTCTGAGCCGCTGTCGAG
  TGATTGTTCTTGAGAAGCTTCCAGTAGAGGCAATGGTGACTATTTTAATGCGAGCGATCAACTCCCTGGG
  AATCCACGTCCTAGACTCTAGCCGTCCCACTGACCCTCTGAGCCACAGCAGCAACAGCAGCTCAGAGCCC
  GCCATGTTCATAGAGGATAAAGCAGTAGACACCCTGGCTTACCTCAGTGACGGTGACGCCCGAGCTGGGT
  TGAACGGACTGCAGCTGGCGGTGCTGGCTAGGTTAAGCTCTAGGAAGATGTTCTGTAAGAAGAGTGGGCA
  ATCCTATTCTCCCAGTAGAGTTCTGATCACAGAGAATGACGTGAAGGAGGGCCTACAGCGATCCCACATT
  TTATATGACCGGGCAGGTGAGGAGCATTACAACTGCATCTCCGCCCTGCACAAGTCCATGCGGGGCTCAG
  ACCAGAACGCCTCCCTCTACTGGCTGGCTCGCATGCTCGAGGGAGGAGAGGACCCACTCTACGTGGCACG
  GAGGCTTGTCAGGTTTGCCAGCGAGGACATAGGTCTGGCAGACCCGTCTGCGTTAACACAAGCGGTTGCT
  GCCTACCAAGGCTGTCATTTTATAGGCATGCCTGAATGTGAGGTGCTTCTGGCCCAGTGTGTGGTCTACT
  TTGCCAGAGCCCCAAAGTCCATTGAGGTGTACAGCGCCTACAACAACGTCAAAGCCTGCCTGAGGAACCA
  CCAGGGGCCACTGCCCCCCGTGCCCCTGCACCTGAGGAACGCGCCCACTAGGCTGATGAAGGATTTGGGC
  TATGGCAAAGGCTACAAGTACAACCCCATGTACAGCGAGCCTGTGGATCAGGAGTACCTGCCTGAAGAGT
  TGAGGGGGGTAGATTTCTTCAAGCAGAGGAGGTGCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_020135
• ORF Size: 1998 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_020135.2, NP_064520.2
• RefSeq Size: 2670
• RefSeq ORF: 1998
• Locus ID: 56897
• Domains: AAA, AAA, ZnF_Rad18
• Gene Summary: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (1) encodes the longer isoform (1).