PANK2 (NM_024960) Human Untagged Clone

CAT#: SC111841

PANK2 (untagged)-Human pantothenate kinase 2 (PANK2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PANK2
• Synonyms: C20orf48; HARP; HSS; NBIA1; PKAN
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111841 sequence for NM_024960 edited (data generated by NextGen Sequencing)
  ATGCCTGCTTTTATTCAAATGGGCAGAGATAAAAACTTCTCGAGTCTCCACACTGTCTTT
  TGTGCCACTGGAGGTGGAGCGTACAAATTTGAGCAGGATTTTCTCACAATAGGTGATCTT
  CAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTTATACATTGACTCA
  GTCGGATTCAATGGACGGTCACAGTGCTATTACTTTGAAAACCCTGCTGATTCTGAAAAG
  TGTCAGAAGTTACCATTTGATTTGAAAAATCCGTATCCTCTGCTTCTGGTGAACATTGGC
  TCAGGGGTTAGCATCTTAGCAGTATATTCCAAAGATAATTACAAACGGGTCACAGGTACT
  AGTCTTGGAGGAGGAACTTTTTTTGGTCTCTGCTGTCTTCTTACTGGCTGTACCACTTTT
  GAAGAAGCTCTTGAAATGGCATCTCGTGGAGATAGCACCAAAGTGGATAAACTAGTACGA
  GATATTTATGGAGGGGACTATGAGAGGTTTGGACTGCCAGGCTGGGCTGTGGCTTCAAGC
  TTTGGAAACATGATGAGCAAGGAGAAGCGAGAGGCTGTCAGTAAAGAGGACCTGGCCAGA
  GCGACTTTGATCACCATCACCAACAACATTGGCTCAATAGCAAGAATGTGTGCCCTTAAT
  GAAAACATTAACCAGGTGGTATTTGTTGGAAATTTCTTGAGAATTAATACGATCGCCATG
  CGGCTTTTGGCATATGCTTTGGATTATTGGTCCAAGGGGCAGTTGAAAGCACTTTTTTCG
  GAACACGAGGGTTATTTTGGAGCTGTTGGAGCACTCCTTGAGCTGTTGAAGATCCCGTGA
  
  Clone variation with respect to NM_024960.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_024960 unedited
  TGTATACGACTCCTATAGGCGGCCGCGAATTCGGCACGAGGGCGAGAAGGAATCCGACGC
  TGGGGGGCTTGCTCGGGCGGCAGCGACTGCTGCTGCGGATGGGAGCGGGCCGGCTCGGCG
  CGCCCATGGAGCGCCACGGCAGGGCTTCCGCCACCTCCGTCTCGTCGGCTGGGGAGCAGG
  CGGCCGGGGACCGCGNAGGGCGGCGGCAGGAGCCACTGCGGCGCCGGGCGAGCAGCGCGT
  CGGTGCCCGCGGTCGGGGCCTCGGCTGAGGGCACGAGGCGGGATCGACTGGGCTCTTACA
  GCGGCCCCACCTCGGTCTCCCGCCAGCGCGTCGAAAGCCTGAGGAAAAAGCGGCCGCTTT
  TTCCATGGTTTGGACTGGATATCGGTGGAACTCTGGTCAAGCTGGTATATTTTGAACCCA
  AAGACATCACTGCTGAAGAAGAAGAGGAAGAAGTGGAAAGTCTTANAAGCATTCGGAAGT
  ACCTGACCTCCAATGTGGCTTATGGGTCTACAGGCATTCGGGACGTGCACCTCGAGCTGA
  AGGACCTGACTCTGTGTGGACGCAAAGGCAATCTGCACTTTATACGCTNTCCCACTCATG
  ACATGCCTGCNTTTATTCAAATGGGCAGAGATAAAAAACTTCTCGAGTCTCCACACTGTC
  TTTTGTGCCACTGGAGGTGGAGCGTACACATTTGAGCAGGATTTTCTCACAATAGGTGAT
  CTTCAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTATACATTGACT
  CCAGTCGATTCCATGGACGGTCACAGTGCTATTACCTTTGAAACCTGCTGATTCTGAAAA
  GTGTCAAAGTTACCATCTGATTTGAAAATCCGCATCCCTGCGTTTGGGGACATTGCCTCA
  GGGTACATCTTACCGATAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_024960 unedited
  NNTTTACTCTGNNACCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTGAAA
  AAAACATGTTTTACAGTAAGTTCACACACAGGCTTAATGCAAACCAGAGTAATGCACAGA
  TGATTGCCAAGACCATATTGACAAATTGTGATTAGATTATAACGCATAGTAGCCTGCCTT
  ACATTCAGCAAGTTCAAACAGGACACAAAACCAGTCAACTGAACACAGAGCAGCTCTCTT
  CAGAAGCACTTCCAATGAGTGATGCAGAGATTTCAAAAATACAAAGCAGGCAACTTATAT
  ACAGCAAATCCTCACACTGCCTGGACATGTGCCACTTTTTTGTTGTTTTTAATATATTTT
  TCCTTCCTGGTTGCTAATTTAGACTGAATTCTTAAGGATTTATCTTGATGACTTAGAAAA
  ATACACCTGTCCTTTCTCACTTTGTTTCAGGTAGTACAGTCATGAAATTGAGTAAGTCTC
  TTAAAAAAATGAAAGTCCACAGATCCCATTGTGGAAGGTTTCAGGAACCCCTCCCCAGGT
  AATGATCACGGGATCTTCAACAGCTCAAGGAGTGCTCCAACAGCTCCAAAATAACCCTCG
  TGTTCCGAAAAAAGTGCTTTCAACTGCCCCTTGGACCAATAATCCAAAGCATATGCCAAA
  AGCCGCATGGCGATCGTATTAATTCTCAAGAAATTTCCAACAAATACCACCTGGTTAATG
  TTTTCATTAAGGGCACACATTCTTGCTATTGAGCCAATGTTGTTGGTGATGGTGATCAAA
  GTCGCTCTGGCCCAGTCCTCTTTACTGACAGCCTCTCGCTTCTCCTTGCTCATCATGTTT
  CCAAAGCTTGAAGCCACAGCCAGCCTGGCAGTCCAACCTCTCATATCCCCTCCATAATAT
  CTCGNACTAATTATCCACTTTGGNGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_024960
• ORF Size: 840 bp
• Insert Size: 1950
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_024960.3, NP_079236.3
• RefSeq Size: 1711
• RefSeq ORF: 840
• Locus ID: 80025
• Domains: Fumble
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Pantothenate and CoA biosynthesis
• Gene Summary: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) has an alternate first exon, and uses a downstream translation initiation site, compared to variant 1. The resulting protein (isoform 2) lacks an N-terminal segment compared to isoform 1, resulting in a shorter protein that shares identity through the C-terminus. Isoform 2 is not expressed in mitochondria. Variants 2, 3 and 7 encode isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.