SELS (SELENOS) (NM_018445) Human Untagged Clone

CAT#: SC111961

VIMP (untagged)-Human selenoprotein S (SELS), transcript variant 2 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below)

Specifications

Product Data

• Type: Human Untagged Clone
• Symbol: SELENOS
• Synonyms: AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111961 sequence for NM_018445 edited (data generated by NextGen Sequencing)
  ATGGAACGCCAAGAGGAGTCTCTGTCCGCGCGGCCGGCCCTGGAGACCGAGGGGCTGCGC
  TTCCTGCACACCACGGTGGGCTCCCTGCTGGCCACCTATGGCTGGTACATCGTCTTCAGC
  TGCATCCTTCTCTACGTGGTCTTTCAGAAGCTTTCCGCCCGGCTAAGAGCCTTGAGGCAG
  AGGCAGCTGGACCGAGCTGCGGCTGCTGTGGAACCTGATGTTGTTGTTAAACGACAAGAA
  GCTTTAGCAGCTGCTCGACTGAAAATGCAAGAAGAACTAAATGCGCAAGTTGAAAAGCAT
  AAGGAAAAACTGAAACAACTTGAAGAAGAAAAAAGGAGACAGAAGATTGAAATGTGGGAC
  AGCATGCAAGAAGGAAAAAGTTACAAAGGAAATGCAAAGAAGCCCCAGGAGGAAGACAGT
  CCTGGGCCTTCCACTTCATCTGTCCTGAAACGGAAATCGGACAGAAAGCCTTTGCGGGGA
  GGAGGTTATAACCCGTTGTCTGGTGAAGGAGGCGGAGCTTGCTCCTGGAGACCTGGACGC
  AGAGGCCCGTCATCTGGCGGATGAGGCTAA
  
  Clone variation with respect to NM_018445.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018445 unedited
  GGTGCGAATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATCGGCACGAGGCGGCG
  GCGGCGGCGGCGGTCATGGAACGCCAAAAGGAGTCTCTGTCCGCGCGGCCGGCCCTGGAG
  ACCGAGGGGCTGCGCTTCCTGCACACCACGGTGGGCTCCCTGCTGGCCACCTATGGCTGG
  TACATCGTCTTCAGCTGCATCCTTCTCTACGTGGTCTTTCAGAAGCTTTCCGCCCGGCTA
  AGAGCCTTGAGGCAGAGGCAGCTGGACCGAGCTGCGGCTGCTGTGGAACCTGATGTTGTT
  GTTAAACGACAAGAAGCTTTAGCAGCTGCTCGACTGAAAATGCAAGAAGAACTAAATGCG
  CAAGTTGAAAAGCATAAGGAAAAACTGAAACAACTTGAAGAAGAAAAAAGGAGACAGAAG
  ATTGAAATGTGGGACAGCATGCAAGAAGGAAAAAGTTACAAAGGAAATGCAAAGAAGCCC
  CAGGAGGAAGACAGTCCTGGGCCTTCCACTTCATCTGTCCTGAAACGGAAATCGGACAGA
  AAGCCTTTGCGGGGAGGAGGTTATAACCCGTTGTCTGGTGAAGGAGGCGGAGCTTGCTCC
  TGGAGACCTGGACGCAGAGGCCCGTCATCTGGCGGATGAGGCTAAGAATCTTGTTAGTGT
  CACTTTTGACATTAGCAAGATGAACCCTTAACCCTCGATTCAATTGCCTTACGCACGCTN
  TTCACAGTGACTAGCCAAGGGAGGTGGGGTTGATTTCTGTTCCTAACTACACCTGCATAT
  GTCAGGGCTCCAGTCAGCAAAGGTATAGATGTTGCCTCTAGCATGAGGTCATGGGTCACA
  TTCTACTNGNAGACAGTGATTGCATTCATTGGATTCATGGGTAATTGCTAGTTGGGTAGT
  A
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018445 unedited
  CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGGAGGTTGTAATAAAAAG
  CTATTTAATGTTTGATAGACAAATTGAAGTCCATAAATCTCCTTGAATAAAGATGCTAAA
  AATGTTATTCTTGTTTTTTAAATAGTTTCGTTTTTACAAAGTTCTGTACATAAAAATAAA
  TATACAGAAACAAACCCCATCAACTGTCCACATCAGTAATCCTCACTGGTGGGCTCACCA
  TTGATAAGGAAGACATCATTCAACGCAACCTGTCACAGAGACTGTCCTAGCAGCAAGGAT
  TTCTAACCTCAAAAGAACATTACTAGGCCTCTTTTATCAAGATTGCTAATCATCTAGAGG
  CCTTTACCTACCAACTAGCAATTAACCATGAAATCAATGAATGCAATCACTGTCTCCAAG
  TAGAATGTGACCAATGACCTCATGCCTAGAGGCAACATCTATACCTTTTGCTGACTGGAG
  CCCTGACATATGCAGGTGTAGTTAGGAACAGAAATCAACCCCACCATCCCTTGGCTAGTC
  ACTGTGAAAAGCGTGCGTAATGCAATTGAATCGAGGGTTAAGGGTTCATCTTGCTAATGT
  CAAAAGTGACACTAACAAGATTCTTAGCCTCATCCGCCAGATGACGGGCCTCTGCGTNCA
  GGTCTCCAGGAGCAAGCTCCGNCTCCTTACCAGACAACGGGTATAACCTCCTNCCCGCAA
  AGGCTTTCTGTCCGATTTCCGTTTCAGGACAGATGAAGTGGAAAGGGCCCAGACTGTCTT
  NCTNCTGGGGCCTCCTTTGCATTTNCTTTGTAACTTTTTNCTTCCTGCATGCTNGCCCAC
  ATTTCAATCTTCTGTCTCCTTTTTTNCTCCTCAAAAGTGGTTCAGNTTTTCCTTATGCTT
  TNCAACTTGCGCATTTAGGTCTTCTTGCTTTTCAATCNAGCAGCTGCTAAAGCTCCTTGT
  CGTTAACACAAACTCAGGTTCCAAGAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018445
• Insert Size: 1240
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins.
• OTI Annotation: This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins.

Reference Data

• RefSeq: NM_018445.4, NP_060915.2
• RefSeq Size: 1250
• Locus ID: 55829
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
  Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1).