Tcl1 (TCL1A) (NM_021966) Human Untagged Clone

CAT#: SC112834

TCL1A (untagged)-Human T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TCL1A
• Synonyms: TCL1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_021966, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCGAGTGCCCGACACTCGGGGAGGCAGTCACCGACCACCCGGACCGCCTGTGGGCCTGGGAGAAGT
  TCGTGTATTTGGACGAGAAGCAGCACGCCTGGCTGCCCTTAACCATCGAGATAAAGGATAGGTTACAGTT
  ACGGGTGCTCTTGCGTCGGGAAGACGTCGTCCTGGGGAGGCCTATGACCCCCACCCAGATAGGCCCAAGC
  CTGCTGCCTATCATGTGGCAGCTCTACCCTGATGGACGATACCGATCCTCAGACTCCAGTTTCTGGCGCT
  TAGTGTACCACATCAAGATTGACGGCGTGGAGGACATGCTTCTCGAGCTGCTGCCAGATGACTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021966 unedited
  TCAGAAATTTGTAATACGACTCACTATAGGGCGGCCCGCGAATTCGCACGAGGAGAAGCA
  GCACGCCTGGCTGCCCTTAACCATCGAGATAAAGGATAGGTTACAGTTACGGGTGCTCTT
  GCGTCGGGAAGACGTCGTCCTGGGGAGGCCTATGACCCCCACCCAGATAGGCCCAAGCCT
  GCTGCCTATCATGTGGCAGCTCTACCCTGATGGACGATACCGATCCTCAGACTCCAGTTT
  CTGGCGCTTAGTGTACCACATCAAGATTGACGGCGTGGAGGACATGCTTCTCGAGCTGCT
  GCCAGATGACTGATGTATGGTCTTGGCAGCACCTGTCTCCTTTCACCCCAGGGCCTGAGC
  CTGGCCAGCCTACAATGGGGATGTTGTGTTTCTGTTCACCTTCGTTTACTATGCCTGTGT
  CTTCTCCACCACGCTGGGGTCTGGGAGGAATGGACAGACAGAGGATGAGCTCTACCCAGG
  GCCTGCAGGACCTGCCTGTAGCCCACTCTGCTCGCCTTAGCACTACCACTCCTGCCAAGG
  AGGATTCCATTTGGCAGAGCTTCTTCCAGGTGCCCAGCTATACCTGTGCCTCGGCTTTTC
  TCAGCTGGATGATGGTCTTCAGCCTCTTTCTGTCCCTTCTGTCCCTCACAGCACTAGTAT
  TTCATGTTGCACACCCACTCAGCTCCGTGAACTTGTGAGAACACAGCCGATTCACCTGAG
  CAGGACCTCTGAAACCCTGGACCAGTGGTCTCACATGGTGCTACGCCTGCATGTAAACAC
  GCCTGNCAACGCTGCCTGCCGGNTAACACGCCCTGCAACGCTGCCTGCCCGTAACACGCC
  TGCAACGCTGCCTGCCACACAGGTTCACGTGCAGCTCAGGNAAGGCCTGAAGGNAGCCNT
  NATCTGTGCTCAGGACTCAGAAGCCTNTGGNGTCAGTGGTCCACATNCCGGNACGCANNC
  AGAGGGCANGCCNGCGAGNCCCTTGTGGNATGACCCTCAGAACCCTGCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021966 unedited
  CGGTTTAGCTATGNNACCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTAG
  ATAAACTATCTTGCATTTAATCAATCATTACAAAAAGTATTCATGCCACATACAACTTTG
  TAACACCCAGGTGCGTGACCATCTATAAAAGGGGGGAAACCCAACCTCTATCCCTTTTCC
  ACGTGGGCAAGCCAAGGGTTCTGAGGGCTCATCCACAGGGCTCGCCGGCCTGGCCTCCTG
  CTGCGTCCCGGGATGTGGACCACTGACCCAGAGGCTTCTGAGTCCTGAGCACAGATAAGG
  GCTCCTTTCAGGCCTTTCCTTGAGCTGCACGTGAACCTGTGTGGGCAGGCAGCGTTTGCA
  GGCGTGTTTACGGGCAGGCAGCGTTTGCAGGCGTGTTTACCGGCAGGCAGCGTTTGCAGG
  CGTGTTTACATGCAGGCGTAGCACCATGTGAGACCACTGGTCCAGGGTTTCAGAGGTCCT
  GCTCAGGTGAATCGGCTGTGTTCTCACAAGTTCACGGAGCTGAGTGGGTGTGCAACATGA
  AATACTAGTGCTGTGAGGGACAGAAGGGACAGAAAGAGGCTGAAGACCATCATCCAGCTG
  AGAAAAGCCGAGGCACAGGTATAGCTGGGCACCTGGAAGAAGCTCTGCCAAATGGAATCC
  TCCTTGGCACGAGTGGTANTGCTAAAGCGAGCAAAGTGGGCTACAAGCAGGTCCTGCAAG
  CCCTGGGTAGAGCTCATCCTCTGTCTGTGCATTCCTTCCAGACCCCAACGTGGTGGAGAA
  GACCCAGCCTAGTTAACCAAAGTGGACAGAAACCAACATTCCCCTTTGTTAGCTGGGCAG
  CCTCAAGGCCTGGGTGGAAAGGAAAAAGGGCTGCCCAAAACATACATAATTATATTGGCA
  GAACTTGGGAGCATGGCCTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021966
• ORF Size: 345 bp
• Insert Size: 1250
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_021966.1, NP_068801.1
• RefSeq Size: 1324
• RefSeq ORF: 345
• Locus ID: 8115
• Protein Families: Druggable Genome
• Gene Summary: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]). [supplied by OMIM, Jul 2010]
  Transcript Variant: This variant (1) and variant 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.