ADAM12 (NM_021641) Human Untagged Clone

CAT#: SC112913

ADAM12 (untagged)-Human ADAM metallopeptidase domain 12 (ADAM12), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADAM12
• Synonyms: ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN; MLTNA
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC112913 sequence for NM_021641 edited (data generated by NextGen Sequencing)
  ATGGCAGCGCGCCCGCTGCCCGTGTCCCCCGCCCGCGCCCTCCTGCTCGCCCTGGCCGGT
  GCTCTGCTCGCGCCCTGCGAGGCCCGAGGGGTGAGCTTATGGAACCAAGGAAGAGCTGAT
  GAAGTTGTCAGTGCCTCTGTTGGGAGTGGGGACCTCTGGATCCCAGTGAAGAGCTTCGAC
  TCCAAGAATCATCCAGAAGTGCTGAATATTCGACTACAACGGGAAAGCAAAGAACTGATC
  ATAAATCTGGAAAGAAATGAAGGTCTCATTGCCAGCAGTTTCACGGAAACCCACTATCTG
  CAAGACGGTACTGATGTCTCCCTCGCTCGAAATTACACGGTAATTCTGGGTCACTGTTAC
  TACCATGGACATGTACGGGGATATTCTGATTCAGCAGTCAGTCTCAGCACGTGTTCTGGT
  CTCAGGGGACTTATTGTGTTTGAAAATGAAAGCTATGTCTTAGAACCAATGAAAAGTGCA
  ACCAACAGATACAAACTCTTCCCAGCGAAGAAGCTGAAAAGCGTCCGGGGATCATGTGGA
  TCACATCACAACACACCAAACCTCGCTGCAAAGAATGTGTTTCCACCACCCTCTCAGACA
  TGGGCAAGAAGGCATAAAAGAGAGACCCTCAAGGCAACTAAGTATGTGGAGCTGGTGATC
  GTGGCAGACAACCGAGAGTTTCAGAGGCAAGGAAAAGATCTGGAAAAAGTTAAGCAGCGA
  TTAATAGAGATTGCTAATCACGTTGACAAGTTTTACAGACCACTGAACATTCGGATCGTG
  TTGGTAGGCGTGGAAGTGTGGAATGACATGGACAAATGCTCTGTAAGTCAGGACCCATTC
  ACCAGCCTCCATGAATTTCTGGACTGGAGGAAGATGAAGCTTCTACCTCGCAAATCCCAT
  GACAATGCGCAGCTTGTCAGTGGGGTTTATTTCCAAGGGACCACCATCGGCATGGCCCCA
  ATCATGAGCATGTGCACGGCAGACCAGTCTGGGGGAATTGTCATGGACCATTCAGACAAT
  CCCCTTGGTGCAGCCGTGACCCTGGCACATGAGCTGGGCCACAATTTCGGGATGAATCAT
  GACACACTGGACAGGGGCTGTAGCTGTCAAATGGCGGTTGAGAAAGGAGGCTGCATCATG
  AACGCTTCCACCGGGTACCCATTTCCCATGGTGTTCAGCAGTTGCAGCAGGAAGGACTTG
  GAGACCAGCCTGGAGAAAGGAATGGGGGTGTGCCTGTTTAACCTGCCGGAAGTCAGGGAG
  TCTTTCGGGGGCCAGAAGTGTGGGAACAGATTTGTGGAAGAAGGAGAGGAGTGTGACTGT
  GGGGAGCCAGAGGAATGTATGAATCGCTGCTGCAATGCCACCACCTGTACCCTGAAGCCG
  GACGCTGTGTGCGCACATGGGCTGTGCTGTGAAGACTGCCAGCTGAAGCCTGCAGGAACA
  GCGTGCAGGGACTCCAGCAACTCCTGTGACCTCCCAGAGTTCTGCACAGGGGCCAGCCCT
  CACTGCCCAGCCAACGTGTACCTGCACGATGGGCACTCATGTCAGGATGTGGACGGCTAC
  TGCTACAATGGCATCTGCCAGACTCACGAGCAGCAGTGTGTCACGCTCTGGGGACCAGGT
  GCTAAACCTGCCCCTGGGATCTGCTTTGAGAGAGTCAATTCTGCAGGTGATCCTTATGGC
  AACTGTGGCAAAGTCTCGAAGAGTTCCTTTGCCAAATGCGAGATGAGAGATGCTAAATGT
  GGAAAAATCCAGTGTCAAGGAGGTGCCAGCCGGCCAGTCATTGGTACCAATGCCGTTTCC
  ATAGAAACAAACATCCCCCTGCAGCAAGGAGGCCGGATTCTGTGCCGGGGGACCCACGTG
  TACTTGGGCGATGACATGCCGGACCCAGGGCTTGTGCTTGCAGGCACAAAGTGTGCAGAT
  GGAAAAATCTGCCTGAATCGTCAATGTCAAAATATTAGTGTCTTTGGGGTTCACGAGTGT
  GCAATGCAGTGCCACGGCAGAGGGGTGTGCAACAACAGGAAGAACTGCCACTGCGAGGCC
  CACTGGGCACCTCCCTTCTGTGACAAGTTTGGCTTTGGAGGAAGCACAGACAGCGGCCCC
  ATCCGGCAAGCAGAAGCAAGGCAGGAAGCTGCAGAGTCCAACAGGGAGCGCGGCCAGGGC
  CAGGAGCCCGTGGGATCGCAGGAGCATGCATCTACTGCCTCACTGACACTCATCTGA
  
  Clone variation with respect to NM_021641.3
  2190 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021641 unedited
  CGTTCACATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACCAGGCTCTTCCTA
  GTCCCCGGGCCAACTCGGACAGTTTGCTCATTTATTGCAACGGTCAAGGCTGGCTTGTGC
  CAGAACGGCGCGCGCGCGCGCACGCACGCACACACACGGGGGGAAACTTTTTTAAAAATG
  AAAGGCTAGAAGAGCTCAGCGGCGGCGCGGGCGCTGCGCGAGGGCTCCGGAGCTGACTCG
  CCGAGGCAGGAAATCCCTCCGGTCGCGACGCCCGGCCCCGGCTCGGCGCCCGCGTGGGAT
  GGTGCAGCGCTCGCCGCCGGGCCCGAGAGCTGCTGCACTGAAGGCCGGCGACGATGGCAG
  CGCGCCCGCTGCCCGTGTCCCCCGCCCGCGCCCTCCTGCTCGCCCTGGCCGGTGCTCTGC
  TCGCGCCCTGCGAGGCCCGAGGGGTGAGCTTATGGAACCAAGGAAGAGCTGATGAAGTTG
  TCAGTGCCTCTGTTGGGAGTGGGGACCTCTGGATCCCAGTGAAGAGCTTCGACTCCAAGA
  ATCATCCAGAAGTGCTGAATATTCGACTACAACGGGAAAGCAAAGAACTGATCATAAATC
  TGGAAAGAAATGAAGGTCTCATTGCCAGCAGTTTCACGGAAACCCACTATCTGCAAGACG
  GTACTGATGTCTCCCTCGCTCGAAATACACGGGTATTCTGGGTCACTGTTACTACCATGG
  ACATGTACGGNGATATTCTGATTCAGCAGTCAGTCTCAGCACGTGTTCTGGTCTCAGGNG
  ACTTATTGTGTTTGAAAATGAAAGCTATGNTCTTANACCNATGGAAANGTGCACCCAACA
  GATACAACTCTTTCCAGCGAAAGAGCTGAANAGCGTCCGGGGGTCATGTTGGTCACATTA
  CAACACACAAAACT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021641 unedited
  AATGGAAATACTGTGNACCGCGCCCTAGCTATGATCNATTTTTCTTTTTTTTTTTTATTT
  CAAATGCACTCTATTTTATGCAGTAATGGCCACGGGGGATGGAGTTAGGCTCTTACATTG
  TTTTCACTTTTTAACATTCTTACTTGTTAAATGAAGGGTTGGTGACTCTGTGGGTTCCCT
  GGCTTTCTGCAAACCCTCAAACCTGAGTACTGTTTTTCACGCATGTCCACAGCAAAGAGC
  CAGAGTTCACCGCCCTTTCTCCTACCTTCTTCTCCAGTTTGTTTCAATGCCATTCAGTTT
  GCTTGGATGGAGATGGAATGGGTGGCAGGGTCTCTGATAAATTAAAAACTAAAACCCTGC
  TATTTTCATATAATAAATGCTAAAAGCCATATCAGAGCATTAAGTTGCAGCCAGAGACCA
  GTCATCAGGGCTGCCAAGGCTGAAGTGTCACTGGGGAAAGGGGACACTGGGCCCAACCCT
  TGCTTCTCCCCCACTGCTGTGGGGGCTCATTGAAAGGCCAGACTTTTGAGTCCTCTTCCT
  CCTTGCTGCAGGGCTGGGGCCTGCCAGAGTGGTAACCTGCTACTCTCTCAAGGGCAGCCC
  TGAAGCATGTCCATGTTTTAGCAGAAGCTCATCCTGGAAGACGCTGCACTACCTTGCCCT
  GTTTTTGCAGACGTGCCTGGTACGCTGCACTTTCCCTCCTGAAAGCCCAAAAACTGACAT
  AAGTCCTGATGTCATGGAAAACCACGGGCCAGGCCCCCAGCCGCAGGCACGTGACCCAAC
  AGAGGGCCACAGGAAACAAAAGGACCATAATTAGATAACCTAATATCTACAAGGACTACC
  GAATTAATGGGGAAGGCCTACAATATAACAGGTAAGCACTTACACAGAAGTGTGGCCGGC
  A
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021641
• ORF Size: 2217 bp
• Insert Size: 3750
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_021641.2, NP_067673.2
• RefSeq Size: 3355
• RefSeq ORF: 2217
• Locus ID: 8038
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane
• Gene Summary: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
  Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as ADAM12-S) has a distinct C-terminus and is shorter than isoform 1.