NCOA62 (SNW1) (NM_012245) Human Untagged Clone

CAT#: SC115506

SNW1 (untagged)-Human SNW domain containing 1 (SNW1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SNW1
• Synonyms: Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SKIP1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_012245 edited
  GCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGAATTTTGT
  AATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCTCGCGCTGGAAGAAGCG
  GAAGAAGATGGCGCTCACCAGCTTTTTACCTGCACCTACTCAGCTATCTCAGGACCAGCT
  TGAGGCTGAAGAAAAGGCAAGATCCCAGAGATCACGGCAGACCTCACTGGTCTCCTCCCG
  AAGAGAACCTCCCCCGTACGGATACCGGAAAGGCTGGATACCTCGGTTATTAGAGGATTT
  TGGAGATGGAGGTGCTTTTCCAGAGATCCATGTGGCCCAGTATCCACTGGATATGGGACG
  AAAGAAAAAAATGTCGAATGCGCTGGCCATTCAGGTGGATTCTGAAGGAAAAATTAAATA
  TGATGCAATTGCTCGACAAGGACAGTCAAAAGACAAGGTCATTTATAGCAAATACACTGA
  CCTGGTTCCAAAGGAGGTTATGAATGCAGATGATCCAGACCTGCAAAGGCCCGATGAAGA
  AGCTATTAAAGAGATAACAGAAAAGACAAGAGTAGCCTTAGAAAAATCTGTATCACAGAA
  GGTCGCCGCAGCCATGCCAGTTCGAGCAGCTGACAAATTGGCTCCTGCTCAGTATATCCG
  ATACACACCATCTCAGCAAGGAGTGGCATTCAACTCTGGAGCTAAACAGAGGGTTATTCG
  GATGGTAGAAATGCAGAAAGATCCAATGGAGCCTCCAAGGTTCAAGATTAATAAGAAAAT
  TCCCCGGGGACCACCTTCTCCTCCTGCGCCTGTCATGCATTCTCCTAGCCGAAAGATGAC
  TGTAAAGGAACAACAAGAGTGGAAGATTCCTCCTTGTATTTCTAACTGGAAAAATGCAAA
  GGGTTATACAATTCCATTAGACAAACGTCTGGCTGCTGATGGAAGAGGACTACAGACAGT
  ACACATAAATGAAAATTTCGCCAAATTGGCAGAAGCCCTCTACATTGCTGATCGGAAGGC
  TCGTGAAGCTGTGGAAATGCGTGCCCAAGTAGAGAGAAAAATGGCTCAGAAAGAAAAGGA
  AAAACATGAAGAGAAACTTAGAGAAATGGCCCAGAAAGCCAGGGAAAGAAGAGCTGGGAT
  CAAAACTCATGTGGAAAAAGAGGATGGGGAGGCACGTGAGAGGGATGAAATCCGGCATGA
  CAGGCGAAAAGAGAGACAGCATGACCGGAATCTTTCCAGGGCAGCTCCTGATAAGAGGTC
  GAAACTTCAGAGAAATGAAAATCGGGATATCAGTGAAGTTATTGCTCTCGGTGTTCCTAA
  TCCTCGGACTTCCAATGAAGTTCAGTATGACCAAAGGCTCTTCAACCAATCCAAGGGTAT
  GGACAGTGGATTTGCAGGTGGAGAAGATGAAATTTATAATGTTTATGATCAAGCCTGGAG
  AGGTGGTAAAGATATGGCCCAGAGTATTTATAGGCCCAGTAAAAATCTGGACAAGGACAT
  GTATGGTGATGACCTAGAAGCCAGAATAAAGACCAACAGATTTGTTCCCGACAAGGAGTT
  TTCTGGTTCAGACCGTAGACAGAGAGGCCGAGAAGGACCAGTTCAGTTTGAGGAAGATCC
  TTTTGGTTTGGACAAGTTTTTGGAAGAAGCCAAACAGCATGGTGGCTCTAAAAGACCCTC
  AGATAGCAGCCGCCCCAAGGAACACGAGCATGAAGGCAAGAAGAGGAGGAAGGAATAGGC
  ACAGGTCTCTCCAAAGTGAATGAACTCTTACCCATAACCCTAATGATGCAAGTCATATGG
  GGGAACACTTTGTAAATGGTCAGGATAAAAACCAAATCTGGGTGCCAGATCCCAGCACTA
  CTTTTTATTACTGGAGAAATGGGGGGGATAGAAAATTCTACTTTGAATTATTTAGTTTTT
  TTTAAAGAGTGGGTTGTGTTTGTGCTTCTCCCACCTTTCAGCATTTATAGAACATGCTGC
  CCCACATACAAAGTCAAGACCACTTACTTTTATGTGACACTAGTAGTTTGGGGTTAATGT
  TTTGTGTAAGAACAGCTGCATATGAGTAAAGTTACCCCAACCACAGTGAGGAGGAAGATG
  TTCACATACTGGAACTGTCCTGCCAAATAAATTTTGCCCCTATTGTGCTCTGTTTTAATT
  TGGAGTGGGCAAAGTAACCTCTTGCTTGGTGCAACTATTTGTTTCAAATAAAAACATTTA
  GACAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCT
  GAACAGATCCCGGGTGGCATCCCTGTGACCCCTCCCCAGTGCCT
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012245 unedited
  GTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCTCGCGCTGGAAGAAG
  CGGAAGAAGATGGCGCTCACCAGCTTTTTACCTGCACCTACTCAGCTATCTCAGGACCAG
  CTTGAGGCTGAAGAAAAGGCAAGATCCCAGAGATCACGGCAGACCTCACTGGTCTCCTCC
  CGAAGAGAACCTCCCCCGTACGGATACCGGAAAGGCTGGATACCTCGGTTATTAGAGGAT
  TTTGGAGATGGAGGTGCTTTTCCAGAGATCCATGTGGCCCAGTATCCACTGGATATGGGA
  CGAAAGAAAAAAATGTCGAATGCGCTGGCCATTCAGGTGGATTCTGAAGGAAAAATTAAA
  TATGATGCAATTGCTCGACAAGGACAGTCAAAAGACAAGGTCATTTATAGCAAATACACT
  GACCTGGTTCCAAAGGAGGTTATGAATGCAGATGATCCAGACCTGCAAAGGCCCGATGAA
  GAAGCTATTAAAGAGATAACAGAAAAGACAAGAGTAGCCTTAGAAAAATCTGTATCACAG
  AAGGTCGCCGCAGCCATGCCAGTTCGAGCAGCTGACAAATTGGCTCCTGCTCAGTATATC
  CGATACACACCATCTCAGCAAGGAGTGGCATTCAACTCTGGAGCTAAACAGAGGGTTATT
  CGGATGGTAGAAATGCAGAAAGATCCAATGGAGCCTCCAAGGTTCAAGATTAATAAGAAA
  ATTCCCCGGNGACCACCTTCTCCTCCTGCGCCTGTCATGCATTCTCCTAGCCGAAAATGA
  CTGGTAAGGAACCAACAGAGTGGAAGAATCCTCCTTGTATTTCTACTGGAAAATGCAAAG
  GTTATACANTNCATTAGACAACGTCTGCTGCTGATGGNAGAGACTACGACGTCACATAAT
  GAAAATTCCCAANTGCAGAGCCTCTACTTGTGATCGAAGCTGTGAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_012245 unedited
  NNNNCCTTACTTGNNACCGCGGCCGCTTTCTAGNATCGAGTTTTTTTTTTTTTTTTTTGT
  CTAAAGTTTTTATTTGAAACAAATAGTTGCACCAAGCAAGAGGTTACTTTGCCCACTCCA
  AATTAAAACAGAGCACAATAGGGGCAAAATTTATTTGGCAGGACAGTTCCAGTATGTGAA
  CATCTTCCTCCTCACTGTGGTTGGGGTAACTTTACTCATATGCAGCTGTTCTTACACAAA
  ACATTAACCCCAAACTACTAGTGTCACATAAAAGTAAGTGGTCTTGACTTTGTATGTGGG
  GCAGCATGTTCTATAAATGCTGAAAGGTGGGAGAAGCACAAACACAACCCACTCTTTAAA
  AAAAACTAAATAATTCAAAGTAGAATTTTCTATCCCCCCCATTTCTCCAGTAATAAAAAG
  TAGTGCTGGGATCTGGCACCCAGATTTGGTTTTTATCCTGACCATTTACAAAGTGTTCCC
  CCATATGACTTGCATCATTAGGGTTATGGGTAAGAGTTCATTCACTTTGGAGAGACCTGT
  GCCTATTCCTTCCTCCTCTTCTTGCCTTCATGCTCGTGTTCCTTGGGGCGGCTGCTATCT
  GAGGGTCTTTTAGAGCCACCATGCTGTTTGGCTTCTTCCAAAAACTTGTCCAAACCAAAA
  GGATCTTCCTCAAACTGAACTGGTCCTTCTCGGCCTCTCTGTCTACGGTCTGAACCAGAA
  AACTCCTTGTCGGNAACANATCTNGTGGTCTTTATTCTGGCTTCTANGTCATCACCCTAC
  ATGTTCCTTGNCCAGATTTTTACTGGGCCTATAAATACTCTGGGCCATATCTTTACCACC
  TCCTCCAGCTTGATCATAAACATTATAAATTCATCTTCTCCACTGCAAANCACTGTCCAT
  ACCTNGGATGGNTGAANAGCTTTGNC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_012245
• ORF Size: 1611 bp
• Insert Size: 2190
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_012245.2, NP_036377.1
• RefSeq Size: 2146
• RefSeq ORF: 1611
• Locus ID: 22938
• Domains: SKIP_SNW
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Notch signaling pathway, Spliceosome
• Gene Summary: This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
  Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.