NKG2D (KLRK1) (NM_007360) Human Untagged Clone

CAT#: SC115560

KLRK1 (untagged)-Human killer cell lectin-like receptor subfamily K, member 1 (KLRK1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLRK1
• Synonyms: CD314; D12S2489E; KLR; NKG2-D; NKG2D
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115560 sequence for NM_007360 edited (data generated by NextGen Sequencing)
  ATGGGGTGGATTCGTGGTCGGAGGTCTCGACACAGCTGGGAGATGAGTGAATTTCATAAT
  TATAACTTGGATCTGAAGAAGAGTGATTTTTCAACACGATGGCAAAAGCAAAGATGTCCA
  GTAGTCAAAAGCAAATGTAGAGAAAATGCATCTCCATTTTTTTTCTGCTGCTTCATCGCT
  GTAGCCATGGGAATCCGTTTCATTATTATGGTAACAATATGGAGTGCTGTATTCCTAAAC
  TCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCT
  AAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGG
  TATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAA
  GAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATT
  CCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACA
  ATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATA
  GAAAACTGTTCAACTCCAAATACATACATCTGCATGCAAAGGACTGTGTAA
  
  Clone variation with respect to NM_007360.3
  624 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007360 unedited
  GTCTTTACCCCGCCCGTTGNCTCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATA
  AGCAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCG
  CGGAACTGAGGACATATCTAAATTTTCTAGTTTTATAGAAGGCTTTTATCCACAAGAATC
  AAGATCTTCCCTCTCTGAGCAGGAATCCTTTGTGCATTGAAGACTTTAGATTCCTCTCTG
  CGGTAGACGTGCACTTATAAGTATTTGATGGGGTGGATTCGTGGTCGGAGGTCTCGACAC
  AGCTGGGAGATGAGTGAATTTCATAATTATAACTTGGATCTGAAGAAGAGTGATTTTTCA
  ACACGATGGCAAAAGCAAAGATGTCCAGTAGTCAAAAGCAAATGTAGAGAAAATGCATCT
  CCATTTTTTTTCTGCTGCTTCATCGCTGTAGCCATGGGAATCCGTTTCATTATTATGGTA
  ACAATATGGAGTGCTGTATTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTG
  ACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTAC
  CAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAAT
  GCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCA
  TATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGC
  TCCATTCTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTC
  TATGCCTCGAGCTTTAAAGCTATATAGAANACTGTTCAACTNCAATACATACATCTGCAT
  GCAAAGGACTGTGTAAAGATGATCAACCATCTCATA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007360 unedited
  CTTAGGACGCGGCCGCATTTAGNATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTGAGACT
  CAGGATTCTATTTATTCAGAGGCAAAATTCCTTCTTAACTGTGAACCTGTGAAACCAAAC
  AAGTTATGTGCTTCCAAAATACAATAGTGGGACAAACATAGGATGGATATTACTATTCCA
  AAAGGAAGAAAGAGAGGAAGAGAAACAGTCATGGGACTCAAGCAAGTACAAATCATAGCA
  AAGGAAACGTCCTAAGATCTTAAGGCTGGAGAATAATGCCTTTAAGATAATCATGGCCCA
  CTGGGGCAGCACCACCTCCCTGACCCCGTTGGGTGGAGGACCCATTAAAAGTGGCAGCAT
  GACCCCCACAGGCAGGGAAGGCACTGCCCATGCTGTGTCTCTCTGCTGTGGCCCTGCCCA
  TGAGGCAATTTCCTGTGGAGGGTGGGGTTGCACTCTCAGTGATCTGCTGGCCTTCTCTTC
  CTTCACTGATCCCCTGGGTGTTGGTCCTACCTTTAGAAATTAAAACAGCACCCCTCCCCC
  AGCCCATCCACTCTGGGCTTGTGGTGGGAGAGGCAGCCTTGGGGATATCTGAATTGCCTT
  TAGGATCTCTCTTCTTTTGTCTTGGAGAATCATGCATGTTTGCAGTGAAATTGTTCTATG
  GTTTGGTCCTGTGGAGTCTAAGAAATCTGACAGTCTTTGGTCATTTTGTCCTGTTTTTGT
  TTGTTTCCTTTAGTCTCGGTTGGCAGTGTTACCGCTGGTGTAATCTCTTCTCTGTTCCTG
  GGCTTTATTGAGATGGGTGATCATCTTTACACAGTCCTTTGCATGCAGATGTATGTATTT
  GGNAGTTGAACAGTTTTCTATATAGCCTTTAAAGCTCGAGGCATAGAGTGCACAGTCTCC
  CTTCTGCATTTCATTTTGTTAGTNGTTGGNTGAAAAAAATGGACCCATTTTCCACTGCCA
  AATAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007360
• ORF Size: 651 bp
• Insert Size: 1750
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_007360.1, NP_031386.1
• RefSeq Size: 1770
• RefSeq ORF: 651
• Locus ID: 22914
• Domains: CLECT
• Protein Families: Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity
• Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]