NKG2D (KLRK1) (NM_007360) Human Untagged Clone

CAT#: SC322611

KLRK1 (untagged)-Human killer cell lectin-like receptor subfamily K, member 1 (KLRK1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLRK1
• Synonyms: CD314; D12S2489E; KLR; NKG2-D; NKG2D
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322611 TGAGGACATATCTAAATTTTCTAGTTTTATAGAAGGCTTTTATCCACAAGAATCAAGATC
  TTCCCTCTCTGAGCAGGAATCCTTTGTGCATTGAAGACTTTAGATTCCTCTCTGCGGTAG
  ACGTGCACTTATAAGTATTTGATGGGGTGGATTCGTGGTCGGAGGTCTCGACACAGCTGG
  GAGATGAGTGAATTTCATAATTATAACTTGGATCTGAAGAAGAGTGATTTTTCAACACGA
  TGGCAAAAGCAAAGATGTCCAGTAGTCAAAAGCAAATGTAGAGAAAATGCATCTCCATTT
  TTTTTCTGCTGCTTCATCGCTGTAGCCATGGGAATCCGTTTCATTATTATGGTAGCAATA
  TGGAGTGCTGTATTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAA
  AGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTT
  TTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGC
  CTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCAT
  TGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATT
  CTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCC
  TCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACATACATCTGCATGCAA
  AGGACTGTGTAAAGATGATCAACCATCTCAATAAAAGCCAGGAACAGAGAAGAGATTACA
  CCAGCGGTAACACTGCCAACCGAGACTAAAGGAAACAAACAAAAACAGGACAAAATGACC
  AAAGACTGTCAGATTTCTTAGACTCCACAGGACCAAACCATAGAACAATTTCACTGCAAA
  CATGCATGATTCTCCAAGACAAAAGAAGAGAGATCCTAAAGGCAATTCAGATATCCCCAA
  GGCTGCCTCTCCCACCACAAGCCCAGAGTGGATGGGCTGGGGGAGGGGTGCTGTTTTAAT
  TTCTAAAGGTAGGACCAACACCCAGGGGATCAGTGAAGGAAGAGAAGGCCAGCAGATCAG
  TGAGAGTGCAACCCCACCCTCCACAGGAAATTGCCTCATGGGCAGGGCCACAGCAGAGAG
  ACACAGCATGGGCAGTGCCTTCCCTGCCTGTGGGGGTCATGCTGCCACTTTTAATGGGTC
  CTCCACCCAACGGGGTCAGGGAGGTGGTGCTGCCCTAGTGGGCCATGATTATCTTAAAGG
  CATTATTCTCCAGCCTTAAGATCTTAGGACGTTTCCTTTGCTATGATTTGTACTTGCTTG
  AGTCCCATGACTGTTTCTCTTCCTCTCTTTCTTCCTTTTGGAATAGTAATATCCATCCTA
  TGTTTGTCCCACTATTGTATTTTGGAAGCACATAACTTGTTTGGTTTCACAGGTTCACAG
  TTAAGAAGGAATTTTGCCTCTGAATAAATAGAATCTTGAGTCTCATGCAAAAAAAAAAAA
  AAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322611 unedited
  TTAGTATCTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGT
  CCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGCTGAGGACATATCTAAATTTTCTA
  GTTTTATAGAAGGCTTTTATCCACAAGAATCAAGATCTTCCCTCTCTGAGCAGGAATCCT
  TTGTGCATTGAAGACTTTAGATTCCTCTCTGCGGTAGACGTGCACTTATAAGTATTTGAT
  GGGGTGGATTCGTGGTCGGAGGTCTCGACACAGCTGGGAGATGAGTGAATTTCATAATTA
  TAACTTGGATCTGAAGAAGAGTGATTTTTCAACACGATGGCAAAAGCAAAGATGTCCAGT
  AGTCAAAAGCAAATGTAGAGAAAATGCATCTCCATTTTTTTTCTGCTGCTTCATCGCTGT
  AGCCATGGGAATCCGTTTCATTATTATGGTAGCAATATGGAGTGCTGTATTCCTAAACTC
  ATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAA
  AAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTTGATGAGAGTAAAAACTGGT
  ATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCCTTCTGAAAGTATACAGCAAA
  GAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATT
  CCCAACAAATGGATTCTTGGCAGTGGAAGGATGGCTCCATTCTTCTCACCCCAACCCTAC
  TAACAATATTGAAATGCAAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTCAAGGCTAT
  TATAGAAACTGTTCACTCCAAATACATACATCTGCATGCAAAGGACTGTTGTAAGATGAT
  CACATTCTCATAAAGCCCAGAACGAGAAGAGATTACCAACGGTACCCTGCCACGGATCCT
  AAGGCAACAATCATAGCCAGGACCAAAT
• Restriction Sites: Please inquire
• ACCN: NM_007360
• ORF Size: 651 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_007360.1, NP_031386.1
• RefSeq Size: 1770
• RefSeq ORF: 651
• Locus ID: 22914
• Domains: CLECT
• Protein Families: Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity
• Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]