RNF139 (NM_007218) Human Untagged Clone

CAT#: SC115641

RNF139 (untagged)-Human ring finger protein 139 (RNF139)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RNF139
• Synonyms: HRCA1; RCA1; TRC8
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115641 sequence for NM_007218 edited (data generated by NextGen Sequencing)
  ATGGCGGCCGTGGGGCCCCCGCAGCAGCAGGTGCGGATGGCCCATCAGCAGGTCTGGGCG
  GCGCTCGAAGTGGCGCTCCGGGTGCCCTGCCTTTACATCATCGACGCCATCTTCAACTCC
  TACCCGGATTCCAGCCAAAGCCGGTTCTGCATCGTGCTCCAGATCTTCCTCCGGCTCTTT
  GGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTAC
  ACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCT
  TTGCACATTGACTTCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCT
  CGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGA
  TACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTG
  GTTCCTGTAATAGGCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTT
  ACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGG
  TTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTATGGA
  TTACAGTTATTGATGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTC
  TTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCA
  AATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTT
  ATAATTAGTGGGTGCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCA
  GTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGAC
  AGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTA
  AGTGGGCTAAGACCAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTA
  ACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCC
  TCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTT
  ATTCTTCCTGTCTTACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTG
  TTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTT
  TATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTAT
  GTCTACTACGTTCGTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTT
  GGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATG
  TGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATG
  AATCGTAGGACTGCTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTA
  CAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATT
  ACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGAT
  ACTTGTCCAATGTGCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAAT
  GTATCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAA
  GCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGAT
  GTTCAAAGAGAAAGAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAAT
  GATGATACTGACTGA
  
  Clone variation with respect to NM_007218.3
  657 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007218 unedited
  GTAATACGACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGTTGCCCGCCTTAGCCCC
  CGCCCCCGGCCGCGGCCCCGGGCCCTGCCCCGCGCGGCCCTGCCCGGCCCACCGAGCCCT
  GGTGTGGCAGCGGCTCATGGCGGCCGTGGGGCCCCCGCAGCAGCAGGTGCGGATGGCCCA
  TCAGCAGGTCTGGGCGGCGCTCGAAGTGGCGCTCCGGGTGCCCTGCCTTTACATCATCGA
  CGCCATCTTCAACTCCTACCCGGATTCCAGCCAAAGCCGGTTCTGCATCGTGCTCCAGAT
  CTTCCTCCGGCTCTTTGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATC
  ACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGT
  GAATTATTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACACGTCAGCTTTTGG
  AATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCT
  AACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAAT
  TATTTTGGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTACCATTACACATCAG
  AGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGC
  AGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACAT
  GTATCCGATTTATGGATTACAGTTATTGATGGAAGACACATGGGAGAGGNNATCGTTCCC
  AGACATACTACGAGTCTTTTTGCCTAACAGAGTACAGCTCAAGCTACAGTGNTAATGTAA
  CATCTAAAGGATGGCAAATGAAACTGATTCCTTTCTTATTTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007218 unedited
  AGCTTTGNACCCGCGGCCGCATNCTANAATCGAGTNTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAAAGGGGAAAACATTTTTTTTTTTGTCC
  AATAATGGCCACAAATTTAAACGGGTCCCCAAAAAAACCAAAAGTATTTAAAGAGGTTTT
  TTTACAGTACCCCATCACAGTAAACGGAAAACCTTTCACAAATTCAACATTGATCCTGTT
  TTTGGGCTGGGTTACCCCCTGAAGGGGAAGGATTTTACTCCTTTTTGGATGAACTGAATT
  TTAAACAAATCCCTCAATCATTAAAAAAGGCTTTTTTCATCAGCCAGTATCATCATTAAA
  TTTTTCAACTGCTGCCCCTGGGGGCTGAAACACTCCATTTTTTTTTTTTTGAACATCATC
  ATCACAATCTGGACTGGCATTTTCGTTAAATTCCCTGGAAAAATAAAAAACAGTTTTTTT
  TACAGTTTCCTTTGGAGTTTCATTGGGGGGAAAAAATCCATTGGGGTAAAACACATTGGA
  ATTATCCTTGATATCATCTTCAAGGGATACTTTTTGAGGGCACATTGGACAAGTTTTTTG
  AATGTACAGCCTTTTCCGAAGGCAAAGTGCATGGAAATAATGATTACACGGGGTAATACG
  ACCAGATGTTGTAAACTCATGATAGCAAATTGCACATACTTCATTTATTTCTTGAAAGCG
  GCTCCCTTTTATTTCAGGAAGGGAATAAATTTTCTTCACGCAGTCCTCGATTAAAAATGT
  CTTCACCCATTTTTGGCTGTAAGTAAATGTAAAAATGCCTGTAGGCCAATATAAAAGCCG
  AATTTTACTTTCCACTAAACTATAGTGTAGCCCATTTCAACTTACAACCCAATTAAATCA
  TAATCCGCTGTGGACAACGAAAAACATATGCAAGCTTCCAAAGACTTTATACCTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007218
• ORF Size: 1995 bp
• Insert Size: 2500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_007218.3, NP_009149.2
• RefSeq Size: 3312
• RefSeq ORF: 1995
• Locus ID: 11236
• Domains: RING
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]