ADAMTS5 (NM_007038) Human Untagged Clone

CAT#: SC115752

ADAMTS5 (untagged)-Human ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADAMTS5
• Synonyms: ADAM-TS 5; ADAM-TS5; ADAM-TS 11; ADAMTS-5; ADAMTS-11; ADAMTS11; ADMP-2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115752 sequence for NM_007038 edited (data generated by NextGen Sequencing)
  ATGCTGCTCGGGTGGGCGTCCCTGCTGCTGTGCGCGTTCCGCCTGCCCCTGGCCGCGGTC
  GGCCCCGCCGCGACACCTGCCCAGGATAAAGCCGGGCAGCCTCCGACTGCTGCAGCAGCC
  GCCCAGCCCCGCCGGCGGCAGGGGGAGGAGGTGCAGGAGCGAGCCGAGCCTCCCGGCCAC
  CCGCACCCCCTGGCGCAGCGGCGCAGGAGCAAGGGGCTGGTGCAGAACATCGACCAACTC
  TACTCCGGCGGCGGCAAGGTGGGCTACCTCGTCTACGCGGGCGGCCGGAGGTTCCTCTTG
  GACCTGGAGCGAGATGGTTCGGTGGGCATTGCTGGCTTCGTGCCCGCAGGAGGCGGGACG
  AGTGCGCCCTGGCGCCACCGGAGCCACTGCTTCTATCGGGGCACAGTGGACGGTAGTCCC
  CGCTCTCTGGCTGTCTTTGACCTCTGTGGGGGTCTCGACGGCTTCTTCGCGGTCAAGCAC
  GCGCGCTACACCCTAAAGCCACTGCTGCGCGGACCCTGGGCGGAGGAAGAAAAGGGGCGC
  GTGTACGGGGATGGGTCCGCACGGATCCTGCACGTCTACACCCGCGAGGGCTTCAGCTTC
  GAGGCCCTGCCGCCGCGCGCCAGCTGCGAAACCCCCGCGTCCACACCGGAGGCCCACGAG
  CATGCTCCGGCGCACAGCAACCCGAGCGGACGCGCAGCACTGGCCTCGCAGCTCTTGGAC
  CAGTCCGCTCTCTCGCCCGCTGGGGGCTCAGGACCGCAGACGTGGTGGCGGCGGCGGCGC
  CGCTCCATCTCCCGGGCCCGCCAGGTGGAGCTGCTTCTGGTGGCTGACGCGTCCATGGCG
  CGGTTGTATGGCCGGGGCCTGCAGCATTACCTGCTGACCCTGGCCTCCATCGCCAATAGG
  CTGTACAGCCATGCTAGCATCGAGAACCACATCCGCCTGGCCGTGGTGAAGGTGGTGGTG
  CTAGGCGACAAGGACAAGAGCCTGGAAGTGAGCAAGAACGCTGCCACCACACTCAAGAAC
  TTTTGCAAGTGGCAGCACCAACACAACCAGCTGGGAGATGACCATGAGGAGCACTACGAT
  GCAGCTATCCTGTTTACTCGGGAGGATTTATGTGGGCATCATTCATGTGACACCCTGGGA
  ATGGCAGACGTTGGGACCATATGTTCTCCAGAGCGCAGCTGTGCTGTGATTGAAGACGAT
  GGCCTCCACGCAGCCTTCACTGTGGCTCACGAAATCGGACATTTACTTGGCCTCTCCCAT
  GACGATTCCAAATTCTGTGAAGAGACCTTTGGTTCCACAGAAGATAAGCGCTTAATGTCT
  TCCATCCTTACCAGCATTGATGCATCTAAGCCCTGGTCCAAATGCACTTCAGCCACCATC
  ACAGAATTCCTGGATGATGGCCATGGTAACTGTTTGCTGGACCTACCACGAAAGCAGATC
  CTGGGCCCCGAAGAACTCCCAGGACAGACCTACGATGCCACCCAGCAGTGCAACCTGACA
  TTCGGGCCTGAGTACTCCGTGTGTCCCGGCATGGATGTCTGTGCTCGCCTGTGGTGTGCT
  GTGGTACGCCAGGGCCAGATGGTCTGTCTGACCAAGAAGCTGCCTGCGGTGGAAGGGACG
  CCTTGTGGAAAGGGGAGAATCTGCCTGCAGGGCAAATGTGTGGACAAAACCAAGAAAAAA
  TATTATTCAACGTCAAGCCATGGCAACTGGGGATCTTGGGGATCCTGGGGCCAGTGTTCT
  CGCTCATGTGGAGGAGGAGTGCAGTTTGCCTATCGTCACTGTAATAACCCTGCTCCCAGA
  AACAACGGACGCTACTGCACAGGGAAGAGGGCCATCTACCGCTCCTGCAGTCTCATGCCC
  TGCCCACCCAATGGTAAATCATTTCGTCATGAACAGTGTGAGGCCAAAAATGGCTATCAG
  TCTGATGCAAAAGGAGTCAAAACTTTTGTGGAATGGGTTCCCAAATATGCAGGTGTCCTG
  CCAGCGGATGTGTGCAAGCTGACCTGCAGAGCCAAGGGCACTGGCTACTATGTGGTATTT
  TCTCCAAAGGTGACCGATGGCACTGAATGTAGGCTGTACAGTAATTCCGTCTGCGTCCGG
  GGGAAGTGTGTGAGAACTGGCTGTGACGGCATCATTGGCTCAAAGCTGCAGTATGACAAG
  TGCGGAGTATGTGGAGGAGACAACTCCAGCTGTACAAAGATTGTTGGAACCTTTAATAAG
  AAAAGTAAGGGTTACACTGACGTGGTGAGGATTCCTGAAGGGGCAACCCACATAAAAGTT
  CGACAGTTCAAAGCCAAAGACCAGACTAGATTCACTGCCTATTTAGCCCTGAAAAAGAAA
  AACGGTGAGTACCTTATCAATGGAAAGTACATGATCTCCACTTCAGAGACTATCATTGAC
  ATCAATGGAACAGTCATGAACTATAGCGGTTGGAGCCACAGGGATGACTTCCTGCATGGC
  ATGGGCTACTCTGCCACGAAGGAAATTCTAATAGTGCAGATTCTTGCAACAGACCCCACT
  AAACCATTAGATGTCCGTTATAGCTTTTTTGTTCCCAAGAAGTCCACTCCAAAAGTAAAC
  TCTGTCACTAGTCATGGCAGCAATAAAGTGGGATCACACACTTCGCAGCCGCAGTGGGTC
  ACGGGCCCATGGCTCGCCTGCTCTAGGACCTGTGACACAGGTTGGCACACCAGAACGGTG
  CAGTGCCAGGATGGAAACCGGAAGTTAGCAAAAGGATGTCCTCTCTCCCAAAGGCCTTCT
  GCGTTTAAGCAATGCTTGTTGAAGAAATGTTAG
  
  Clone variation with respect to NM_007038.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007038 unedited
  CCCATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGCAGACACGCC
  GCTTCACCAGCTCGCCTCAGGCTGCCCCCCTGCATTTTTGTTTTAATTTTTACGGCTTTT
  TCCCCTCTCTTTCTTCCCTTCCTCCTGGTCCCAGCAGAGCCAAGGAAACCCACAAAATAA
  GAAAGGAAGTGGGCCCCGGAGCTTGGAACCTCCACAGCCGGCTTGTCCAGCGCAGCGCGG
  GGGCGGGAGGCTGCGCGCACCAGTTGCCAGCCCGGTGCGCGGTACCTTTCCTTACTTTTC
  TTGAAACAGCGATCGTGCCTGCATTTGGTGGTTTTTTGGTTTTTGTTTTTTTCCTTTTCC
  CGTATTTGCTGAATCTCCACTATCCGACTTTTTTTTTTTAATCTTTTCTTTCCCCCCCCC
  CACCCCACCTCTTTCTGGAGCACGAATCCAAACATTTTCCCAAGCAACAAAGAAAAGTTC
  GCACGCTGGCACCGCAGCCCGGACAGGCTGGCGCTGCTGCCGGGCCCCCCTCCCTCCGAC
  ACTTGACTCAATCCTGCAAGCAAGTGTGTGTGTGTCCCCATCCCCCGCCCCGTTAACTTC
  ATAGCAAATAACAAATACCCATAAAGTCCCAGTCGCGCAGCCCCTCCCCGCGGGCAGCGC
  ACTATGCTGCTCGGGTGGGCGTCCCTGCTGCTGTGCGCGTTCCGCCTGCCCCTGGCCGCG
  GTCGGCCCCGCCGCGACACCTGCCCAGGATAAAGCCGGCAGCCTCCGACTGCTGCAGCAG
  CCGCCCACCCCCCCGGCGGCAGGGGGAAGAAGTGCAAGANCGAGCCNAGCCTNCCGGCCA
  CCCGCACCCCTGGCGCANCGGCGCAGAGCAGGGGCTGGTGCAGACATCGACAACTCTACT
  CGGCGCGGCAAGTGGGCTAACTGTCTAGCGGGCGGCGGGGTTCTCTTGACCTGACGGATG
  TT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007038 unedited
  ATCGAAGTTTTTTTTCTTTTTTTTTTTATAGAAATTATATGGGTATTTTAATAGAACCAG
  GGGATATAAAGTGACATACCAAGGGAGAATGTATTTACAAACAGTAAGAAGAAGCTACTG
  TGTATTATGGGTGAAAATGATTATGATACCATTAAAGACATTCTATCAGAGGTAGGTGAC
  AAGGGGGAGACAGTTCTGCCATCTTCAAATGTCCCCTGATTTTACATTCATCAGTGTTTC
  TTGTAAGCCCAGGGGATGTTCAATAACTCCCAAGTTTTTCTATATTGCAAGGTCACCACT
  GTCACGTGAAGCAGTGCACATCCTCTTTTGGTCACAGAGAGCAGATTCTGCCCATAATTG
  GACTCCTGTTGACAATGTCACTGAAGCATGACTTTCTGTGCGTTAGGTAGACCTCCTGTT
  CACCACGACTGCATCAGTGCTGAATCCTCCAGTTATCTTTGTGCATAAGATCATAACCAC
  AGGCTAACATTTCTTCAACAAGCATTGCTTANACGCAGAAGGCCTTTGGGAGAGAGGACA
  TCCTTTTGCTAACTTNCGGTTTCCATCCTGGCACTGCACCGTTCNTGGTGTGCCAAACCT
  GTGTCACAGGTCCTAGAGCAGGCGAGCCATGGGCCCGTGACCCACTGCGGCTGCGAAGTG
  TGTGATCCCACTTTATTGCTGNCATGACTAGTGACAGAGTTTACTTTTGGAGTGGACTTC
  CTGGGGACCAAAAAGCTATTACGGAACTCTAAGGGTTTATGGGGGTCCTGTTGCAGAATT
  CTGCACTATTAAAATTTCCTTCGCGGGCCNGATTACCCCCTCCCATGCCAGAAAGTCCTC
  CCCTGTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007038
• ORF Size: 2793 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_007038.2, NP_008969.1
• RefSeq Size: 9046
• RefSeq ORF: 2793
• Locus ID: 11096
• Domains: tsp_1, Reprolysin, ACR
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]