FMO3 (NM_006894) Human Untagged Clone

CAT#: SC115806

FMO3 (untagged)-Human flavin containing monooxygenase 3 (FMO3), transcript variant 1


  "NM_006894" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol FMO3
Synonyms dJ127D3.1; FMOII; TMAU
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC115806 sequence for NM_006894 edited (data generated by NextGen Sequencing)
ATGGGGAAGAAAGTGGCCATCATTGGAGCTGGTGTGAGTGGCTTGGCCTCCATCAGGAGC
TGTCTGGAAGAGGGGCTGGAGCCCACCTGCTTTGAGAAGAGCAATGACATTGGGGGCCTG
TGGAAATTTTCAGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCC
AACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAAC
TTTATGCACAACAGCAAGATCCAGGAATATATCATTGCATTTGCCAAAGAAAAGAACCTC
CTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCA
ACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTT
GATGCTGTAATGGTTTGTTCCGGACATCATGTGTATCCCAACCTACCAAAAGAGTCCTTT
CCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGT
GTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCC
ACAGAACTCAGCCGCACAGCAGAACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTG
ATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGA
ACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACATGAAGCAGATG
AATGCAAGATTCAAGCATGAAAACTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAA
GAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTCCGTAAAG
CCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAG
GGCATTGACTGTGTAATCTTTGCAACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAG
TCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTA
CTTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCC
ACAGTTGACCTCCAGTCCCGCTGGGCAGCACAAGTAATAAAGGGAACTTGTACTTTGCCT
TCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAAATGGTTT
GGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTC
ATTGGGGCAAAGCCCAACATCCCATGGCTGTTTCTCACAGATCCCAAATTGGCCATGGAA
GTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCAGTGGCCA
GGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGA
GTGGTCGGGAGACTTCAGAAGCCTTGCTTTTTTTTCCATTGGCTGAAGCTCTTTGCAATT
CCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAA

Clone variation with respect to NM_006894.5
769 g=>a;1530 c=>t
>OriGene 5' read for NM_006894 unedited
GCACCAGAAGGTTGGACAGGACGTAGACACACAGAAGAAAAGAAGACAAAGAACGGGTAG
GAAAATTAAAAAGGTTACCATGGNGGAAGAAAGTGGCCATCATTGGAGCTGGTGTGAGTG
GCTTGGCCTCCATCAGGAGCTGTCTGGAAGAGGGGCTGGAGCCCACCTGCTTTGAGAAGA
GCAATGACATTGGGGGCCTGTGGAAATTTTCAGACCATGCAGAGGAGGGCAGGGCTAGCA
TTTACAAATCAGTCTTTTCCAACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCAT
TTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCAGGAATATATCATTGCAT
TTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAA
ATAAACATCCTGATTTTGCAACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTA
AAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGGACATCATGTGTATCCCA
ACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCA
GGGACTATAAAGAACCAGGTGTATTCAATGGAAAGCGTGTCCTGGNTGGTTGGCCTGGGG
AAATTCGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGAAACAGGTCATGATCAG
TTNCCAGAAGTGGCTCCTGGGT
>OriGene 3' read for NM_006894 unedited
NNNNTTTACTTGNNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTATAATTATATCTGCTTAATTTGCTCTTTATTTAAATTTAAAATACATCTTT
CATACATTGTTTAAAAGGAAAAAGGAATCATGTCAAAATGTTTCAGGAAATGATTTAAGT
TAAATATAAAGAACATAGTTCTGATTTTGAAGTGTTAGTGGAACTCAAACAGAAATGATT
AGTGCTCTCTTAAGATCATGACATGATTCTTAAAGTGGCTATTTCAAAGCCTAAAAATAA
CACTGTATTACTGACTAATGTCTACAGAGTACTGCAAAAGATGCTGAATAGAAAAGCAGG
TGGTGTGAAAATTTTAATTTTTAAATAGCAAAGCCCCTGTCTGGGTATTGTCAGTAACTT
TCAAAAATCCTAGAGAAAATGATGATTAGGTCAACACAAGGAAAACAGCGATTAACAGAA
TAGGAATTGCAAAGAGCTTCAGCCAATGGAAAAAAAAGCAAGGCTTCTGAAGTCTCCCGA
CCACTCGTGTCTGCATGGGTTTCAACGACCGGTCCCACTGGGTCAGTATGGCATTTCTGG
CTCCTGGCCACTGCCCTGGGCCCACCAGCCTAAACTGGTAGGGACTACAAGGGCCAAAAT
AAACTTCCATGGNCCAATTTGGGATCTGTGAGAAACAGCCATGGGATGTTGGGCTTTGCC
CCAATGAAGGAGGGAGAGTTCATCCATATAAACAATGTAATCTGTCTGTATGGTCTCGCT
TTTGCCAAACATTTGCNGCTTTTCTNCTTNTTCTCATTAATATCATTNCATCATGTCTCC
ATAGAAGGGCAAGTACAGTTCCTTTTATTACTGTGCTGCCCAGCGGACTGGAGGGTCACT
GTGGAATGCAGCCCCAGGGACTGGACAAGCCATACTGCTATGGTGACTTTC
Restriction Sites NotI-NotI     
ACCN NM_006894
Insert Size 2140 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_006894.4, NP_008825.4
RefSeq Size 2053 bp
RefSeq ORF 1599 bp
Locus ID 2328
Cytogenetics 1q24.3
Domains FMO-like
Protein Families Druggable Genome, Transmembrane
Protein Pathways Drug metabolism - cytochrome P450
Gene Summary 'Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]'
Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 both encode the same isoform (a).

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