JAB1 (COPS5) (NM_006837) Human Untagged Clone

CAT#: SC115830

COPS5 (untagged)-Human COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COPS5
• Synonyms: CSN5; JAB1; MOV-34; SGN5
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006837, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCGTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTGGCCAACAACATGCAGGAAGCTCAGA
  GTATCGATGAAATCTACAAATACGACAAGAAACAGCAGCAAGAAATCCTGGCGGCGAAGCCCTGGACTAA
  GGATCACCATTACTTTAAGTACTGCAAAATCTCAGCATTGGCTCTGCTGAAGATGGTGATGCATGCCAGA
  TCGGGAGGCAACTTGGAAGTGATGGGTCTGATGCTAGGAAAGGTGGATGGTGAAACCATGATCATTATGG
  ACAGTTTTGCTTTGCCTGTGGAGGGCACTGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAATACAT
  GGCTGCATACATAGAAAATGCAAAACAGGTTGGCCGCCTTGAAAATGCAATCGGGTGGTATCATAGCCAC
  CCTGGCTATGGCTGCTGGCTTTCTGGGATTGATGTTAGTACTCAGATGCTCAATCAGCAGTTCCAGGAAC
  CATTTGTAGCAGTGGTGATTGATCCAACAAGAACAATATCCGCAGGGAAAGTGAATCTTGGCGCCTTTAG
  GACATACCCAAAGGGCTACAAACCTCCTGATGAAGGACCTTCTGAGTACCAGACTATTCCACTTAATAAA
  ATAGAAGATTTTGGTGTACACTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCCTCTTTGG
  ATCGCAAATTGCTTGAGCTGTTGTGGAATAAATACTGGGTGAATACGTTGAGTTCTTCTAGCTTGCTTAC
  TAATGCAGACTATACCACTGGTCAGGTCTTTGATTTGTCTGAAAAGTTAGAGCAGTCAGAAGCCCAGCTG
  GGACGAGGGAGTTTCATGTTGGGTTTAGAAACGCATGACCGAAAATCAGAAGACAAACTTGCCAAAGCTA
  CAAGAGACAGCTGTAAAACTACCATAGAAGCTATCCATGGATTGATGTCTCAGGTTATTAAGGATAAACT
  GTTTAATCAAATTAACATCTCTTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006837 unedited
  AGGTTCAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCAAGAGTC
  TAGGTAAGAGTTTGTTCCCGTGGTGCGGAGGGTCAAGGCCCACACCCGGAAACCTAGCGA
  GGTGAAGTTGCGTCTTGGTTGTAGAGACGACAACTTCTCCGCTTCCTCGGCGATGGCGGC
  GTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTGGCCAACAACATGCAGGAAGCTCA
  GAGTATCGATGAAATCTACAAATACGACAAGAAACAGCAGCAAGAAATCCTGGCGGCGAA
  GCCCTGGACTAAGGATCACCATTACTTTAAGTACTGCAAAATCTCAGCATTGGCTCTGCT
  GAAGATGGTGATGCATGCCAGATCGGGAGGCAACTTGGAAGTGATGGGTCTGATGCTAGG
  AAAGGTGGATGGTGAAACCATGATCATTATGGACAGTTTTGCTTTGCCTGTGGAGGGCAC
  TGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAATACATGGCTGCATACATAGAANA
  TGCGAAACAGGTTGGCCGCCTTGAANATGCATCGGGTGGTATCATAGCCACCCTGGCTAT
  GGCTGCTGGCTTTCTGGGATTTGATGTAGTACTCAGATGCTCAATCAGCAGTTCCAGGAA
  CCATTTGTAGCAGTGGTGATTGATCCAACNNAGACATATCCGCAGGGAAGTGAATCTTGG
  CGCCTTNAGACATACCCAAAAGGCTACAAACTNCTGATGAGGACCTTCTGAGTACAGACT
  ATTCCACTTTATAAATAGAGATTTTGGTGTACACTGCAAACAATATATGCTTTAGAGTCT
  CTATTTCAAACCCTCTTGGATCGCAAATGCTTGAGCTTGTGTGGATAAATCTGGGTGAAT
  ACCTTGAGTTCTTCAAGCTGGCTACAAAGCAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006837 unedited
  ACTTCCAGGGCCAGNATAGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGNATCTGTT
  CAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCA
  TTTTAAAGAGCTTTATTACAGGATATTAATATTTAGGACACTTCAGAGCACCTTATACTT
  CTAATCAAATTTTGGGTAACTGGTTTTAAAGGGGTACTTGAATATTTTTCTCATACTGGC
  TTTCAGGGAAAGTACTTCTCAAAGACTGTTTAAGAGATGTTAATTTGATTAAACAGTTTA
  TCCTTAATAACCTGAGACATCAATCCATGGATAGCTTTTATGGTAGTTTTACAGCTGTCT
  TTTGTAGCTTTGGCAAGTTTGTCTTCTGATTTTCGGTCATGCGTTTCTAAACCCAACANN
  NAACTCCCTCGTCCCAGCTGGGCTTCTGACTGCTCTAACTTTTCAAACAAATCAAAGACC
  TGACCAGTGGTATAGTCTGCATTAGTAAGCAAGCTAGAAAAACTCAACGTATTCACCCAG
  TATTTATTCCACAACAGCTCAAGCAATTNTGCGATCCAAAGAGGATTTGAAATATGAGAC
  TTCTAAGGCATAATATTGTTTGCAGTGGTCACCAAAATCTTCTATTTTATTAAGTGGAAT
  AGTCTGGTACTCAGAAAGGTCCTTATCAGGAGGTTGGTAGCCCTTTGGGTATGTCCTAAA
  GGCGCCCAGATTACTTTACNNNNAATATGTTTCTGGTTGATCAATCACCACTGCTACAAA
  GGGGTCCTGGAACTGCTGANTGACATCTGAGTACTAACATCATCCCAAAAGNCAGCAGCC
  ATAGCCAGGGTGGCTATGATACCACCCGTTGCATTTCAGGCGGGCCACCTGTTCGCATTT
  CTATGTTGCAGCCTGTTTTATTAGCAGAGCCTGACAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006837
• ORF Size: 1005 bp
• Insert Size: 1330
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006837.2, NP_006828.2
• RefSeq Size: 1510
• RefSeq ORF: 1005
• Locus ID: 10987
• Domains: JAB_MPN
• Protein Families: Druggable Genome, Protease, Transcription Factors
• Gene Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]