JAB1 (COPS5) (NM_006837) Human Untagged Clone

CAT#: SC320662

COPS5 (untagged)-Human COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COPS5
• Synonyms: CSN5; JAB1; MOV-34; SGN5
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006837.2 GTGTCATGGCTGCCCCAAGAGTCTAGGTAAGAGTTTGTTCCCGTGGTGCGGAGGGTCAAG
  GCCCACACCCGGAAACCTAGCGAGGTAAAGTTGCGTCTTGGTTGTAGAGACGACAACTTC
  TCCGCTTCCTCGGCGATGGCGGCGTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTG
  GCCAACAACATGCAGGAAGCTCAGAGTATCGATGAAATCTACAAATACGACAAGAAACAG
  CAGCAAGAAATCCTGGCGGCGAAGCCCTGGACTAAGGATCACCATTACTTTAAGTACTGC
  AAAATCTCAGCATTGGCTCTGCTGAAGATGGTGATGCATGCCAGATCGGGAGGCAACTTG
  GAAGTGATGGGTCTGATGCTAGGAAAGGTGGATGGTGAAACCATGATCATTATGGACAGT
  TTTGCTTTGCCTGTGGAGGGCACTGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAA
  TACATGGCTGCATACATAGAAAATGCAAAACAGGTTGGCCGCCTTGAAAATGCAATCGGG
  TGGTATCATAGCCACCCTGGCTATGGCTGCTGGCTTTCTGGGATTGATGTTAGTACTCAG
  ATGCTCAATCAGCAGTTCCAGGAACCATTTGTAGCAGTGGTGATTGATCCAACAAGAACA
  ATATCCGCAGGGAAAGTGAATCTTGGCGCCTTTAGGACATACCCAAAGGGCTACAAACCT
  CCTGATGAAGGACCTTCTGAGTACCAGACTATTCCACTTAATAAAATAGAAGATTTTGGT
  GTACACTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCCTCTTTGGATCGC
  AAATTGCTTGAGCTGTTGTGGAATAAATACTGGGTGAATACGTTGAGTTCTTCTAGCTTG
  CTTACTAATGCAGACTATACCACTGGTCAGGTCTTTGATTTGTCTGAAAAGTTAGAGCAG
  TCAGAAGCCCAGCTGGGACGAGGGAGTTTCATGTTGGGTTTAGAAACGCATGACCGAAAA
  TCAGAAGACAAACTTGCCAAAGCTACAAGAGACAGCTGTAAAACTACCATAGAAGCTATC
  CATGGATTGATGTCTCAGGTTATTAAGGATAAACTGTTTAATCAAATTAACATCTCTTAA
  ACAGTCTCTGAGAAGTACTTTACCTGAAAGACAGTATGAGAAAAATATTCAAGTAACACT
  TTAAAACCAGTTACCCAAAATCTGATTAGAAGTATAAGGTGCTCTGAAGTGTCCTAAATA
  TTAATATCCTGTAATAAAGCTCTTTAAAATGAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006837.2 unedited
  GCGATTGTATACGACTCCTATAGGGCGGCCGGGAAATTCGGCACGAGGGTGTCATGGCTG
  CCCCAAGAGTCTAGGTAAGAGTTTGTTCCCGTGGTGCGGAGGGTCAAGGCCCACACCCGG
  AAACCTAGCGAGGTAAAGTTGCGTCTTGGTTGTAGAGACGACAACTTCTCCGCTTCCTCG
  GCGATGGCGGCGTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTGGCCAACAACATG
  CAGGAAGCTCAGAGTATCGATGAAATCTACAAATACGACAAGAAACAGCAGCAAGAAATC
  CTGGCGGCGAAGCCCTGGACTAAGGATCACCATTACTTTAAGTACTGCAAAATCTCAGCA
  TTGGCTCTGCTGAAGATGGTGATGCATGCCAGATCGGGAGGCAACTTGGAAGTGATGGGT
  CTGATGCTAGGAAAGGTGGATGGTGAAACCATGATCATTATGGACAGTTTTGCTTTGCCT
  GTGGAGGGCACTGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAATACATGGCTGCA
  TACATAGAAAATGCAAAACAGGTTGGCCGCCTTGAAAATGCAATCGGGTGGTATCATAGC
  CACCCTGGCTATGGCTGCTGGCTTTCTGGGATTGATGTTAGTACTCAGATGCTCAATCAG
  CAGTTCCAGGAACCATTTGTAGCAGTGGTGATTGATCCAACAAGAACAATATCCGCAGGA
  AAAGTGAATCTTGGCGCCTTTAGGACATACCCAAGGGCTACAACCTCTGATGAAGACCTT
  CTGGAGTACCAGACTATTCCACTTAATAAAATAAAAGAATTTTGTGTACACTGCAAGACA
  ATATTATGCCTAGAAGTCTCCATATTTCAATCCTCTTTGATCCGCAAATTGCTGGACTGT
  GTGGAATAATACTGATGAATACGTGAGTTTTCTAACTTGCTTACATATGCCACCT
• Restriction Sites: Please inquire
• ACCN: NM_006837
• ORF Size: 1005 bp
• Insert Size: 1300
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006837.2, NP_006828.2
• RefSeq Size: 1510
• RefSeq ORF: 1005
• Locus ID: 10987
• Domains: JAB_MPN
• Protein Families: Druggable Genome, Protease, Transcription Factors
• Gene Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]