RGS14 (NM_006480) Human Untagged Clone

CAT#: SC116059

RGS14 (untagged)-Human regulator of G-protein signaling 14 (RGS14)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RGS14
• Synonyms: regulator of G-protein signaling 14; regulator of G-protein signalling 14
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC116059 sequence for NM_006480 edited (data generated by NextGen Sequencing)
  ATGCCAGGGAAGCCCAAGCACCTGGGCGTCCCCAACGGGCGCATGGTTCTGGCTGTGTCA
  GATGGAGAGCTGAGCAGCACGACGGGGCCCCAGGGCCAGGGCGAGGGCCGCGGCAGCTCT
  CTCAGCATCCACAGCCTCCCCAGTGGTCCCAGCAGCCCCTTCCCAACCGAGGAGCAGCCT
  GTGGCCAGCTGGGCCCTGTCCTTCGAGCGGCTGTTGCAGGACCCGCTGGGCCTGGCTTAC
  TTCACTGAGTTCCTGAAGAAGGAGTTCAGCGCGGAAAACGTGACTTTCTGGAAGGCCTGC
  GAGCGCTTCCAGCAGATCCCGGCCAGCGATACCCAGCAGCTAGCTCAGGAGGCCCGCAAC
  ATCTACCAGGAGTTCCTGTCCAGCCAGGCGCTGAGCCCAGTGAACATCGACCGTCAGGCC
  TGGCTTGGCGAGGAGGTGCTGGCCGAGCCCCGGCCGGACATGTTTCGGGCACAGCAGCTT
  CAGATCTTCAACTTGATGAAGTTCGACAGCTATGCGCGCTTCGTCAAGTCCCCGCTGTAC
  CGCGAGTGCCTGCTAGCCGAAGCCGAGGGACGCCCTCTGCGGGAACCTGGCTCCTCGCGC
  CTCGGCAGCCCTGACGCCACGAGGAAGAAGCCGAAGCTGAAGCCCGGGAAGTCGCTGCCG
  CTGGGTGTGGAGGAGTTGGGGCAGCTGCCACCCGTTGAGGGTCCTGGGGGCCGCCCTCTC
  CGCAAGTCCTTCCGCCGGGAGCTGGGCGGGACTGCAAACGCCGCCTTGCGCCGAGAGTCT
  CAGGGCTCCCTCAACTCCTCCGCCAGCCTGGACCTTGGCTTCCTAGCCTTCGTCAGCAGC
  AAATCTGAGAGCCACCGGAAGAGCCTTGGGAGCACGGAGGGTGAAAGTGAAAGCCGGCCA
  GGGAAGTACTGCTGTGTGTACCTGCCCGATGGCACAGCCTCCTTGGCCCTGGCCAGACCT
  GGCCTCACCATCCGAGACATGCTGGCAGGGATCTGTGAGAAACGAGGCCTCTCTCTACCT
  GACATCAAGGTCTACCTGGTGGGCAATGAACAGGCCCTGGTCCTGGATCAGGACTGCACC
  GTGCTGGCGGATCAGGAAGTGCGGCTGGAAAACAGGATCACCTTCGAGCTGGAGCTGACG
  GCGCTGGAGCGCGTGGTACGAATCTCAGCCAAGCCCACCAAGCGGCTGCAGGAGGCGCTG
  CAGCCCATTCTGGAGAAGCACGGCTTGAGCCCGCTAGAGGTGGTGCTGCACCGGCCAGGC
  GAGAAACAGCCTCTGGATCTGGGGAAGCTAGTGAGCTCGGTGGCGGCCCAGAGACTGGTT
  TTGGACACTCTTCCAGGTGTGAAGATCTCCAAAGCCCGTGACAAATCTCCCTGCCGCAGC
  CAGGGCTGCCCACCTAGAACTCAGGATAAGGCCACCCATCCCCCTCCAGCGTCCCCCAGT
  TCTCTGGTGAAGGTGCCCAGTAGTGCCACTGGAAAGCGGCAGACCTGTGACATCGAAGGC
  CTGGTGGAGCTGCTGAACCGGGTGCAGAGCAGCGGGGCCCACGACCAGAGGGGCCTTCTG
  AGGAAAGAGGACCTGGTACTTCCAGAATTTCTGCAGCTGCCCGCCCAAGGGCCCAGCTCC
  GAGGAGACCCCACCACAGACCAAATCAGCAGCCCAGCCCATCGGGGGATCCTTGAACTCC
  ACCACCGACTCAGCCCTCTGA
  
  Clone variation with respect to NM_006480.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006480 unedited
  CAAATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATTCGCACCAGGCCGAGTCAG
  GCTCTCTCCCTGCCTGCCCGCCACCGTGCAAGCTCTGGCCGGCGCTGCCCACAGTCCCCA
  TGGTGGGCAGCCCCCGCGGCGGGGACCCCTGATCGGCAGCGGCATGCCAGGGAAGCCCAA
  GCACCTGGGCGTCCCCAACGGGCGCATGGTTCTGGCTGTGTCAGATGGAGAGCTGAGCAG
  CACGACGGGGCCCCAGGGCCAGGGCGAGGGCCGCGGCAGCTCTCTCAGCATCCACAGCCT
  CCCCAGTGGTCCCAGCAGCCCCTTCCCAACCGAGGAGCAGCCTGTGGCCAGCTGGGCCCT
  GTCCTTCGAGCGGCTGTTGCAGGACCCGCTGGGCCTGGCTTACTTCACTGAGTTCCTGAA
  GAAGGAGTTCAGCGCGGAAAACGTGACTTTCTGGAAGGCCTGCGAGCGCTTCCAGCAGAT
  CCCGGCCAGCGATACCCAGCAGCTAGCTCAGGAGGCCCGCAACATCTACCAGGAGTTCCT
  GTCCAGCCAGGCGCTGAGCCCAGTGAACATCGACCGTCAGGCCTGGCTTGGCGAGGAGGT
  GCTGGCCGAGCCCCCGCCGGACATGTTTCGGGCACAGCAGCTTCAGATCTTCAACTTGAT
  GAAGTTCGACAGCTATGCGCGCTTCGTCAAGTCCCCGCTGTACCGCGAGTGCCTGCTAGC
  CGAAGCCGAGGGACGCCCTCTGCGGNAACCTGGNCTCTCGCGCCCTCGCAGCCCTGACGC
  CACGAGGAAGAAGCCGAAGCTGAAGCCCNGGAAGTCGCTGCCGCTGGGTGTGGAGGAAGN
  TGGNGCANCTGCCANCCGNNTGAGGGTCCTGGGGGGCCGNCCCTCTTCGCAGTCCTTTNC
  GCGGNAGCCTGGCGGAACTGCAAACGCCCGCTGCGCCGANAGTCTAAGGNCTCCTTCAAC
  TCTNCGCAGCCTGGACCTTGTTTNCTAGNCTCGTAGCAGAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006480 unedited
  GACGCCGGACAAACCCCACCCTTTTNNTTANTTTTACTTGNACCCGGCCGCATACTANGA
  TCGATTTTTTTTTTTTTTTTTTTTGCAGAAAAATAATAATTATTATAATAACAGTATCAT
  ACATCAAGGACAAACCCAGCTGCCCCAAGCCTACTGCAAAATCTGTATGTACAGTATAGT
  CTATGTGGGTGGGGTACAGGGCTGCCTGCCTGCACCCTCAAGGCCTTACTCATACCAGCT
  TCCTGAGGAGGGGCCGGCCCCTCCTCTTGCCCCTGTTGAAGCTTGGCACAGGCTGGGGAG
  GCTGGCACTGCCAACGCCATCCCTCCATGTTGGGCAAGCCTGTTCCAAGGGGCTGGACTC
  ACCTCCCCCATTGTGGCCTGGCTGCAAGGGATTGGGGGTGAGCTTGTTGAGGGACAAGGC
  GGTGGCAGCTGTGGGGTGTGTCTCATCTGAGTCCCCTTTCCACCCCTACCGGCTCTTCCT
  GCGGGCCTGCCCATGGCAGGAAGGGGCCAGGGACACTCATGGCACAGACAGGGCATGCAG
  AGCGGACCCATGGCATGCTCGGCCCGCCGGGTGCCATGCAGCTGTCCTGGACTGTTGGGT
  AGCTGTCAAAGGGCTGAGTCGGTGGTGGAGTTCAAGGATCCCCCGATGGGCTGGGCTGCT
  GATTTGGTCTGTGGTGGGGTCTTCTCTGGACCTGGCCCTTGGGCGGGCAGTTGCAAAAAT
  CTTGAAAGACCCAGTCCTTTTTCCTTAAAAGGCCCTTTTGTCCGGGGGCCCCCTGGTCTT
  GAACCTGTTTAAGAACTTTCCCCAGCTTTTTATGTCACAAGTTTTGCCCCTTTCCAAGGG
  GACTACGGGGCACCTCCCCACAAAATGGGGGACCCTTTAGGGGCAAGGGCGGCCTTATCT
  CTGATTTTAGGGGGCAAACCCTGCTTCGCAAGAAAATTTTTACCGGTTTCTAAATTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006480
• ORF Size: 1701 bp
• Insert Size: 2560
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006480.4, NP_006471.2
• RefSeq Size: 2418
• RefSeq ORF: 1701
• Locus ID: 10636
• Domains: RGS, GoLoco, RBD
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]