RGS14 (NM_006480) Human Untagged Clone

CAT#: SC324464

RGS14 (untagged)-Human regulator of G-protein signaling 14 (RGS14)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RGS14
• Synonyms: regulator of G-protein signaling 14; regulator of G-protein signalling 14
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006480.4 GTAGTGAGCGGTGTTTCAGGATGTGAGGGCCCGCAGGAGCCGAGTCAGGCTCTCTCCACT
  GCCTGCCCGCCACCGTGCAAGCTCTGGCCGGCGCTGCCCACAGTCCCCATGGTGGGCAGC
  CCCCGCGGCGGGGACCCCTGATCGGCAGCGGCATGCCAGGGAAGCCCAAGCACCTGGGCG
  TCCCCAACGGGCGCATGGTTCTGGCTGTGTCAGATGGAGAGCTGAGCAGCACGACGGGGC
  CCCAGGGCCAGGGCGAGGGCCGCGGCAGCTCTCTCAGCATCCACAGCCTCCCCAGTGGTC
  CCAGCAGCCCCTTCCCAACCGAGGAGCAGCCTGTGGCCAGCTGGGCCCTGTCCTTCGAGC
  GGCTGTTGCAGGACCCGCTGGGCCTGGCTTACTTCACTGAGTTCCTGAAGAAGGAGTTCA
  GCGCGGAAAACGTGACTTTCTGGAAGGCCTGCGAGCGCTTCCAGCAGATCCCGGCCAGCG
  ATACCCAGCAGCTAGCTCAGGAGGCCCGCAACATCTACCAGGAGTTCCTGTCCAGCCAGG
  CGCTGAGCCCAGTGAACATCGACCGTCAGGCCTGGCTTGGCGAGGAGGTGCTGGCCGAGC
  CCCGGCCGGACATGTTTCGGGCACAGCAGCTTCAGATCTTCAACTTGATGAAGTTCGACA
  GCTATGCGCGCTTCGTCAAGTCCCCGCTGTACCGCGAGTGCCTGCTAGCCGAAGCCGAGG
  GACGCCCTCTGCGGGAACCTGGCTCCTCGCGCCTCGGCAGCCCTGACGCCACGAGGAAGA
  AGCCGAAGCTGAAGCCCGGGAAGTCGCTGCCGCTGGGTGTGGAGGAGTTGGGGCAGCTGC
  CACCCGTTGAGGGTCCTGGGGGCCGCCCTCTCCGCAAGTCCTTCCGCCGGGAGCTGGGCG
  GGACTGCAAACGCCGCCTTGCGCCGAGAGTCTCAGGGCTCCCTCAACTCCTCCGCCAGCC
  TGGACCTTGGCTTCCTAGCCTTCGTCAGCAGCAAATCTGAGAGCCACCGGAAGAGCCTTG
  GGAGCACGGAGGGTGAAAGTGAAAGCCGGCCAGGGAAGTACTGCTGTGTGTACCTGCCCG
  ATGGCACAGCCTCCTTGGCCCTGGCCAGACCTGGCCTCACCATCCGAGACATGCTGGCAG
  GGATCTGTGAGAAACGAGGCCTCTCTCTACCTGACATCAAGGTCTACCTGGTGGGCAATG
  AACAGGCCCTGGTCCTGGATCAGGACTGCACCGTGCTGGCGGATCAGGAAGTGCGGCTGG
  AAAACAGGATCACCTTCGAGCTGGAGCTGACGGCGCTGGAGCGCGTGGTACGAATCTCAG
  CCAAGCCCACCAAGCGGCTGCAGGAGGCGCTGCAGCCCATTCTGGAGAAGCACGGCTTGA
  GCCCGCTAGAGGTGGTGCTGCACCGGCCAGGCGAGAAACAGCCTCTGGATCTGGGGAAGC
  TAGTGAGCTCGGTGGCGGCCCAGAGACTGGTTTTGGACACTCTTCCAGGTGTGAAGATCT
  CCAAAGCCCGTGACAAATCTCCCTGCCGCAGCCAGGGCTGCCCACCTAGAACTCAGGATA
  AGGCCACCCATCCCCCTCCAGCGTCCCCCAGTTCTCTGGTGAAGGTGCCCAGTAGTGCCA
  CTGGAAAGCGGCAGACCTGTGACATCGAAGGCCTGGTGGAGCTGCTGAACCGGGTGCAGA
  GCAGCGGGGCCCACGACCAGAGGGGCCTTCTGAGGAAAGAGGACCTGGTACTTCCAGAAT
  TTCTGCAGCTGCCCGCCCAAGGGCCCAGCTCCGAGGAGACCCCACCACAGACCAAATCAG
  CAGCCCAGCCCATCGGGGGATCCTTGAACTCCACCACCGACTCAGCCCTCTGACAGCTAC
  CCAACAGTCCAGGACAGCTGCATGGCACCCGGCGGGCCGAGCATGCCATGGGTCCGCTCT
  GCATGCCCTGTCTGTGCCATGAGTGTCCCTGGCCCCTTCCTGCCATGGGCAGGCCCGCAG
  GAAGAGCCGGTAGGGGTGGAAAGGGGACTCAGATGAGACACACCCCACAGCTGCCACCGC
  CTTGTCCCTCAACAAGCTCACCCCCAATCCCTTGCAGCCAGGCCACAATGGGGGAGGTGA
  GTCCAGCCCCTTGGAACAGGCTTGCCCAACATGGAGGGATGGCGTTGGCAGTGCCAGCCT
  CCCCAGCCTGTGCCAAGCTTCAACAGGGGCAAGAGGAGGGGCCGGCCCCTCCTCAGGAAG
  CTGGTATGAGTAAGGCCTTGAGGGTGCAGGCAGGCAGCCCTGTACCCCACCCACATAGAC
  TATACTGTACATACAGATTTTGCAGTAGGCTTGGGGCAGCTGGGTTTGTCCTTGATGTAT
  GATACTGTTATTATAATAATTATTATTATTCTGCAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006480.4 unedited
  GGGCCATTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGCGTAGTGAG
  CGGTGTTTCAGGATGTGAGGGCCCGCAGGAGCCGAGTCAGGCTCTCTCCACTGCCTGCCC
  GCCACCGTGCAAGCTCTGGCCGGCGCTGCCCACAGTCCCCATGGTGGGCAGCCCCCGCGG
  CGGGGACCCCTGATCGGCAGCGGCATGCCAGGGAAGCCCAAGCACCTGGGCGTCCCCAAC
  GGGCGCATGGTTCTGGCTGTGTCAGATGGAGAGCTGAGCAGCACGACGGGGCCCCAGGGC
  CAGGGCGAGGGCCGCGGCAGCTCTCTCAGCATCCACAGCCTCCCCAGTGGTCCCAGCAGC
  CCCTTCCCAACCGAGGAGCAGCCTGTGGCCAGCTGGGCCCTGTCCTTCGAGCGGCTGTTG
  CAGGACCCGCTGGGCCTGGCTTACTTCACTGAGTTCCTGAAGAAGGAGTTCAGCGCGGAA
  AACGTGACTTTCTGGAAGGCCTGCGAGCGCTTCCAGCAGATCCCGGCCAGCGATACCCAG
  CAGCTAGCTCAGGAGGCCCGCAACATCTACCAGGAGTTCCTGTCCAGCCAGGCGCTGAGC
  CCAGTGAACATCGACCGTCAGGCCTGGCTTGGCGAGGAGGTGCTGGCCGAGCCCCGGCCG
  GACATGTTTCGGGCACAGCAGCTTCAGATCTTCAACTTGATGAAGTTCGACAGCTATGCG
  CGCTTCGTCAAGTCCCCGCTGTACCGCGAGTGCCTGCTAGCCGAAGCCGAGGGACGCCCT
  CTGCGGGAACCTGCTCCTCGCGCCTCGGCAGCCCTTGACGCCACGAGAAGAAGCCGAAGC
  TGAAGCCGGTAAGTCGCCTGCCGCTGGGTGGTGAGGATTGGGTCACCTTGCCACTCGGTG
  CGAGTTCCTGG
• Restriction Sites: Please inquire
• ACCN: NM_006480
• ORF Size: 1701 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006480.4, NP_006471.2
• RefSeq Size: 2418
• RefSeq ORF: 1701
• Locus ID: 10636
• Domains: RGS, GoLoco, RBD
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]