TAB1 (NM_006116) Human Untagged Clone

CAT#: SC116337

TAB1 (untagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha


  "NM_006116" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TAB1
Synonyms 3'-Tab1; MAP3K7IP1
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116337 sequence for NM_006116 edited (data generated by NextGen Sequencing)
ATGGCGGCGCAGAGGAGGAGCTTGCTGCAGAGTGAGCAGCAGCCAAGCTGGACAGATGAC
CTGCCTCTCTGCCACCTCTCTGGGGTTGGCTCAGCCTCCAACCGCAGCTACTCTGCTGAT
GGCAAGGGCACTGAGAGCCACCCGCCAGAGGACAGCTGGCTCAAGTTCAGGAGTGAGAAC
AACTGCTTCCTGTATGGGGTCTTCAACGGCTATGATGGCAACCGAGTGACCAACTTCGTG
GCCCAGCGGCTGTCCGCAGAGCTCCTGCTGGGCCAGCTGAATGCCGAGCACGCCGAGGCC
GATGTGCGGCGTGTGCTGCTGCAGGCCTTCGATGTGGTGGAGAGGAGCTTCCTGGAGTCC
ATTGACGACGCCTTGGCTGAGAAGGCAAGCCTCCAGTCGCAATTGCCAGAGGGAGTCCCT
CAGCACCAGCTGCCTCCTCAGTATCAGAAGATCCTTGAGAGACTCAAGACGTTAGAGAGG
GAAATTTCGGGAGGGGCCATGGCCGTTGTGGCGGTCCTTCTCAACAACAAGCTCTACGTC
GCCAATGTCGGTACAAACCGTGCACTTTTATGCAAATCGACAGTGGATGGGTTGCAGGTG
ACACAGCTGAACGTGGACCACACCACAGAGAACGAGGATGAGCTCTTCCGTCTTTCGCAG
CTGGGCTTGGATGCTGGAAAGATCAAGCAGGTGGGGATCATCTGTGGGCAGGAGAGCACC
CGGCGGATCGGGGATTACAAGGTTAAATATGGCTACACGGACATTGACCTTCTCAGCGCT
GCCAAGTCCAAACCAATCATCGCAGAGCCAGAAATCCATGGGGCACAGCCGCTGGATGGG
GTGACGGGCTTCTTGGTGCTGATGTCGGAGGGGTTGTACAAGGCCCTAGAGGCAGCCCAT
GGGCCTGGGCAGGCCAACCAGGAGATTGCTGCGATGATTGACACTGAGTTTGCCAAGCAG
ACCTCCCTGGACGCAGTGGCCCAGGCCGTCGTGGACCGGGTGAAGCGCATCCACAGCGAC
ACCTTCGCCAGTGGTGGGGAGCGTGCCAGGTTCTGCCCCCGGCACGAGGACATGACCCTG
CTAGTGAGGAACTTTGGCTACCCGCTGGGCGAAATGAGCCAGCCCACACCGAGCCCAGCC
CCAGCTGCAGGAGGACGAGTGTACCCTGTGTCTGTGCCATACTCCAGCGCCCAGAGCACC
AGCAAGACCAGCGTGACCCTCTCCCTTGTCATGCCCTCCCAGGGCCAGATGGTCAACGGG
GCTCACAGTGCTTCCACCCTGGACGAAGCCACCCCCACCCTCACCAACCAAAGCCCGACC
TTAACCCTGCAGTCCACCAACACGCACACGCAGAGCAGCAGCTCCAGCTCTGACGGAGGC
CTCTTCCGCTCCCGGCCCGCCCACTCGCTCCCGCCTGGCGAGGACGGTCGTGTTGAGCCC
TATGTGGACTTTGCTGAGTTTTACCGCCTCTGGAGCGTGGACCATGGCGAGCAGAGCGTG
GTGACAGCACCGTAG

Clone variation with respect to NM_006116.2
>OriGene 5' read for NM_006116 unedited
NNGGCTCCTTCCCCCGCCCGTTCCCTCAAAGGGCGGTAGGCGTGTACGGTGGGAAGGTCT
ATATAAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAG
CGGCCGCGAATTCGGCACGAGGGGGGTTCCTCCAAGATGGCGGCGCAGAGGAGGAGCTTG
CTGCAGAGTGAGCAGCAGCCAAGCTGGACAGATGACCTGCCTCTCTGCCACCTCTCTGGG
GTTGGCTCAGCCTCCAACCGCAGCTACTCTGCTGATGGCAAGGGCACTGAGAGCCACCCG
CCAGAGGACAGCTGGCTCAAGTTCAGGAGTGAGAACAACTGCTTCCTGTATGGGGTCTTC
AACGGCTATGATGGCAACCGAGTGACCAACTTCGTGGCCCAGCGGCTGTCCGCAGAGCTC
CTGCTGGGCCAGCTGAATGCCGAGCACGCCGAGGCCGATGTGCGGCGTGTGCTGCTGCAG
GCCTTCGATGTGGTGGAGAGGAGCTTCCTGGAGTCCATTGACGACGCCTTGGCTGAGAAG
GCAAGCCTCCAGTCGCAATTGCCAGAGGGAGTCCCTCAGCACCAGCTGCCTCCTCAGTAT
CAGAAGATCCTTGAGAGACTCAAGACGTTAGAGAGGGAAATTTCGGGAGGGGCCATGGCC
GTTGTGGCGGTCCTTCTCAACAACAAGCTCTACGTCGCCAATGTCGGTACAAACCGTGCA
CTTTTATGCAAATCGACAGTGGATGGGTTGCAGGTGACACAGCTGAACGTGGACCACACC
ACAGAGAACGAGGATGAGCTCTTCCGTCTTTCGCAGCTGGGCTTGGATGCTGGAAAGATC
AAGCAGGTGGGGGATCATCTGTGGGCAGGAGAGCACCCGGCGGATCGGGGATTACAAGGT
AAATATGGCTACACG
>OriGene 3' read for NM_006116 unedited
GCGGTATACCAGTACGCGCCCCATTCTANATCGAGTTTTTTTTTTTTTTTTTTTTTTTTT
AATATCATAATGTGTAATGCCACCATTTATGACTTCTTTACTACATTAAAAAATGACCCT
GTTTCTAGAGACCAAACAGCACCACAGAGGCATTCTTGGAAGAAAATTCCTTTTGTTCCC
AAGCCTTTGTGACTGACTTTAAATCCTCTCACCTGCTTTAATAAAGATGGCTTCAAAGTG
GGGGGGGGGGGAGTGAGCGAGGACCCTGGGCTGAGACCTGTTTTTCTTCCATTTCTGCTG
TGGCTTCCCACAGCTCCCTGGTTCCACACCAAGCCCTGCTCTGCCGCAAGAAAATGGATT
CCCAGGCCACAAAGCTGTTAGGCCTTTGACTTTGCAAAAACCAAAAACCCCAAAAGCTGG
GCCACAGCGGCTAAACCCTGGTGGGCCCGTCCGGGGCATGGGGGGCACGGACACTGGCAG
ATGGGGAGGGCGTCCAAAAAACCAGGGGATCTGGGAGGAGGAACAACAGGGTATACGACT
AACCACGGCTGACCCCCCGGACCCACGGATCAACCAAAGTTCCGACTACCCCCCGCCCAT
TACCATCAACACCGCACAGACAAACCCATCGCCCCGCAACAGACCGGGGGACAAACTGCG
CGAACACCCCGCAGAGAAATGAGGCTGCCAAACGCCCACACAGAGGAACTCCCCCGGGCC
CGTCCACACACCTCTTCTCCTCCTCTCACCATCCTCACACACACACCCCCCACCCCAGGA
CACTCCTCCACCACATTATATATAAATTAACCCTCCCTATAACGATAATAATAGCGCGTC
ACACCCCCCCCAAAATATGAAACACACCATTTAACGCACCGCCTTCAATCATTGACACCC
CAAATAAAGACATA
Restriction Sites NotI-NotI     
ACCN NM_006116
ORF Size 1515 bp
Insert Size 3500
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_006116.2, NP_006107.1
RefSeq Size 3240
RefSeq ORF 1515
Locus ID 10454
Domains PP2C
Protein Families Druggable Genome
Protein Pathways MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
Gene Summary The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (alpha) encodes the longer isoform (alpha).

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