TAB1 (NM_006116) Human Untagged Clone

CAT#: SC322672

TAB1 (untagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TAB1
• Synonyms: 3'-Tab1; MAP3K7IP1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322672 CTCTAGCCGCCCCACTCGCTGCTCTGCGGGGAGGCGGGCGCTCCCGCAGGGGTTCCTCCA
  AGATGGCGGCGCAGAGGAGGAGCTTGCTGCAGAGTGAGCAGCAGCCAAGCTGGACAGATG
  ACCTGCCTCTCTGCCACCTCTCTGGGGTTGGCTCAGCCTCCAACCGCAGCTACTCTGCTG
  ATGGCAAGGGCACTGAGAGCCACCCGCCAGAGGACAGCTGGCTCAAGTTCAGGAGTGAGA
  ACAACTGCTTCCTGTATGGGGTCTTCAACGGCTATGATGGCAACCGAGTGACCAACTTCG
  TGGCCCAGCGGCTGTCCGCAGAGCTCCTGCTGGGCCAGCTGAATGCCGAGCACGCCGAGG
  CCGATGTGCGGCGTGTGCTGCTGCAGGCCTTCGATGTGGTGGAGAGGAGCTTCCTGGAGT
  CCATTGACGACGCCTTGGCTGAGAAGGCAAGCCTCCAGTCGCAATTGCCAGAGGGAGTCC
  CTCAGCACCAGCTGCCTCCTCAGTATCAGAAGATCCTTGAGAGACTCAAGACGTTAGAGA
  GGGAAATTTCGGGAGGGGCCATGGCCGTTGTGGCGGTCCTTCTCAACAACAAGCTCTACG
  TCGCCAATGTCGGTACAAACCGTGCACTTTTATGCAAATCGACAGTGGATGGGTTGCAGG
  TGACACAGCTGAACGTGGACCACACCACAGAGAACGAGGATGAGCTCTTCCGTCTTTCGC
  AGCTGGGCTTGGATGCTGGAAAGATCAAGCAGGTGGGGATCATCTGTGGGCAGGAGAGCA
  CCCGGCGGATCGGGGATTACAAGGTTAAATATGGCTACACGGACATTGACCTTCTCAGCG
  CTGCCAAGTCCAAACCAATCATCGCAGAGCCAGAAATCCATGGGGCACAGCCGCTGGATG
  GGGTGACGGGCTTCTTGGTGCTGATGTCGGAGGGGTTGTACAAGGCCCTAGAGGCAGCCC
  ATGGGCCTGGGCAGGCCAACCAGGAGATTGCTGCGATGATTGACACTGAGTTTGCCAAGC
  AGACCTCCCTGGACGCAGTGGCCCAGGCCGTCGTGGACCGGGTGAAGCGCATCCACAGCG
  ACACCTTCGCCAGTGGTGGGGAGCGTGCCAGGTTCTGCCCCCGGCACGAGGACATGACCC
  TGCTAGTGAGGAACTTTGGCTACCCGCTGGGCGAAATGAGCCAGCCCACACCGAGCCCAG
  CCCCAGCTGCAGGAGGACGAGTGTACCCTGTGTCTGTGCCATACTCCAGCGCCCAGAGCA
  CCAGCAAGACCAGCGTGACCCTCTCCCTTGTCATGCCCTCCCAGGGCCAGATGGTCAACG
  GGGCTCACAGTGCTTCCACCCTGGACGAAGCCACCCCCACCCTCACCAACCAAAGCCCGA
  CCTTAACCCTGCAGTCCACCAACACGCACACGCAGAGCAGCAGCTCCAGCTCTGACGGAG
  GCCTCTTCCGCTCCCGGCCCGCCCACTCGCTCCCGCCTGGCGAGGACGGTCGTGTTGAGC
  CCTATGTGGACTTTGCTGAGTTTTACCGCCTCTGGAGCGTGGACCATGGCGAGCAGAGCG
  TGGTGACAGCACCGTAGGGCAGCCGGAGAATGCAGCCCAAGCAGGGCCTGGCATGGGGCA
  GGACAGGGTCCAGCCTTTTCCTAACATCTGCCTGTGCCACAACGGCCAGCAGGTGCCCCA
  TCCTCTGCCCACAGCAGACTCTGTCCCATGGCTCTCCGGGCAGTAGAGTGTGTGAGTGCA
  GACTGGACCTGTGGTTCATACCTTGTCACCACCCGGGAAGCTGAAGGCCACTTCCTCCCA
  GATGGCCTCAGCCAGGACCATCGCCCTTTCTCAGAGCAGAGGGCCAGGTATAGAAACCGC
  AGTGGGCCTGCAAGCCGCCCGAGCCTCCCCAGCAGCCTCCTACAGAGCAGGAAGAGGCGC
  CCTGTGAACCCTGAGTGTTGCAGGCCCAGCAGACCCTGCTGTCCCAAGCCCACCCCTCCT
  CCCACCATCACCTCCCTCACCTCGGGACAGTAGCCCTCCACTTCTCCAGCCTCTCAGCCC
  TGTGCTCCTGCATCCAGAGTGGAACCCAGGCTGGTGTCCGCATCTGTCCCTGGGCCCCAC
  CCCTGGACCTGCCTTGGTTGTGTCATCTGTTGTAAACGTTCAGGAGGACCAGGGCAGCAT
  CTGGGGCCTGGGATGGCCACAGAAGGGGCAGGCCAGGTGGAAAGGAGCCAGGGGGAAGTG
  GTCTAAGAGACCTGGAACTGCCAGAGGATGGCGGCCTGGGCTTCCCCAGAGCCAGGCGTG
  CGGGAGAGGTGAGGACTGGCCCCGGTGGGCTGAGGCAGGGGCCGCTGTCGTCAGGCCTGA
  GCCAGGGTGAGCTGGTGCCTGCCTTGCATTTTCCTTCTGGTGCTGTGAAGACCATAGGCT
  GGCAGGCAGCTGAGATGAACTGTCTTTACCACTGATGAGGGGCCTCTGCCGGCTGAGGGT
  AGCAAGCAGGGGTTGTGAGTCAGGCTGGGGGACTTGTTTGAAAGAAAGAGGAGTGGAAAA
  TGGTTCCAGGAGGGAAGAGGTTCTTTGAGACACAGTACCCTGGGAGGCATAGGAGAAGGG
  TCGGGCCAGCCCAGCCCAGGGCCTGAGTTAGACTATTTCCCACATGTTCTCTGCCTTCAG
  TGGGGAGGGGGTGCCACCAGGGCTGTCGGCCAGGATTGCCACTCCTGTTTCAGAGGAAGC
  AGGCCGAGAGACTTGCACCTTGGCCAAGCCACACAATCAGTGGGGCAGCCAGAGCTCAGA
  CCTGAGCCATTTTGTCAGTATCCAGGACCCCCCGGATTCTCCACGCCCTCCCCATCTCCC
  AGTCTCCCTGCCCCCCATGCCCCAGACCGGCCCACCAGGGACTAGCCGCTGTCGCACAGC
  CTCTGGGGTGCTTGGTCTCTGCGAAGTCAAAGGCCTGACAGCTCTGTGGCCTGGGAATCC
  ATTTTCCTGCGGCAGAGCAGGGCCTGGTGTGGAACCAGGGAGCTGTGGGAAGCCACAGCA
  GAAATGGAAGAAAAACAGGTCTCAGCCCAGGGTCCTCGCTCACTCCCTCACTCCCCACTT
  TGAAGCCATCTCTGTTCTGCAGGTGAGAGGATTTAAAGTCAGTCACAAAGGCTTGGGAAC
  AAAAGGAATTCTCTTCCAAGAATGCCTCTGTGGTGCTGTTTGGTCTCTAGAAACAGGGTC
  ACTTTTTTAATGTAGTAAAGAAGTAATAAATGGTGGCATTACACATTGTGATATTAAAAA
  AAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322672 unedited
  ACCGTATCTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGT
  CCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGCTCTAGCCGCCCCACTCGCTGCTC
  TGCGGGGAGGCGGGCGCTCCCGCAGGGGTTCCTCCAAGATGGCGGCGCAGAGGAGGAGCT
  TGCTGCAGAGTGAGCAGCAGCCAAGCTGGACAGATGACCTGCCTCTCTGCCACCTCTCTG
  GGGTTGGCTCAGCCTCCAACCGCAGCTACTCTGCTGATGGCAAGGGCACTGAGAGCCACC
  CGCCAGAGGACAGCTGGCTCAAGTTCAGGAGTGAGAACAACTGCTTCCTGTATGGGGTCT
  TCAACGGCTATGATGGCAACCGAGTGACCAACTTCGTGGCCCAGCGGCTGTCCGCAGAGC
  TCCTGCTGGGCCAGCTGAATGCCGAGCACGCCGAGGCCGATGTGCGGCGTGTGCTGCTGC
  AGGCCTTCGATGTGGTGGAGAGGAGCTTCCTGGAGTCCATTGACGACGCCTTGGCTGAGA
  AGGCAAGCCTCCAGTCGCAATTGCCAGAGGGAGTCCCTCAGCACCAGCTGCCTCCTCAGT
  ATCAGAAGATCCTTGAGAGACTCAAGACGTTAGAGAGGGAAATTTCGGGAGGGGCCATGG
  CCCGTTGTGGCGGTCCTTCTCAACAACAAGCTCTACGTCGCCAATGTCGGTACAAACCGT
  GCACTTTTATGCAAATCGACAGTGATGGGTTGCATGTGACACAGCTGACGTGGACCACAC
  CACAGAGACGAGGATGAGCTCTCGTCTTTCGCAGCTGGGCTTGGATGCTGTAAGAATCAG
  CAGGTGGGGATCATTCTGTGGCCAGAAGAGCACCGGCGAATCCGGGATTACAGGATAAAT
  ATGTTAACCGAACTTGAACTTTTAGGCGCTGCCAAGTTCCAACCA
• Restriction Sites: Please inquire
• ACCN: NM_006116
• ORF Size: 1515 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006116.2, NP_006107.1
• RefSeq Size: 3240
• RefSeq ORF: 1515
• Locus ID: 10454
• Domains: PP2C
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (alpha) encodes the longer isoform (alpha).