LXR alpha (NR1H3) (NM_005693) Human Untagged Clone

CAT#: SC116564

NR1H3 (untagged)-Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NR1H3
• Synonyms: LXR-a; LXRA; RLD-1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_005693 edited
  ATGTCCTTGTGGCTGGGGGCCCCTGTGCCTGACATTCCTCCTGACTCTGCGGTGGAGCTG
  TGGAAGCCAGGCGCACAGGATGCAAGCAGCCAGGCCCAGGGAGGCAGCAGCTGCATCCTC
  AGAGAGGAAGCCAGGATGCCCCACTCTGCTGGGGGTACTGCAGGGGTGGGGCTGGAGGCT
  GCAGAGCCCACAGCCCTGCTCACCAGGGCAGAGCCCCCTTCAGAACCCACAGAGATCCGT
  CCACAAAAGCGGAAAAAGGGGCCAGCCCCCAAAATGCTGGGGAACGAGCTATGCAGCGTG
  TGTGGGGACAAGGCCTCGGGCTTCCACTACAATGTTCTGAGCTGCGAGGGCTGCAAGGGA
  TTCTTCCGCCGCAGCGTCATCAAGGGAGCGCACTACATCTGCCACAGTGGCGGCCACTGC
  CCCATGGACACCTACATGCGTCGCAAGTGCCAGGAGTGTCGGCTTCGCAAATGCCGTCAG
  GCTGGCATGCGGGAGGAGTGTGTCCTGTCAGAAGAACAGATCCGCCTGAAGAAACTGAAG
  CGGCAAGAGGAGGAACAGGCTCATGCCACATCCTTGCCCCCCAGGGCTTCCTCACCCCCC
  CAAATCCTGCCCCAGCTCAGCCCGGAACAACTGGGCATGATCGAGAAGCTCGTCGCTGCC
  CAGCAACAGTGTAACCGGCGCTCCTTTTCTGACCGGCTTCGAGTCACGCCTTGGCCCATG
  GCACCAGATCCCCATAGCCGGGAGGCCCGTCAGCAGCGCTTTGCCCACTTCACTGAGCTG
  GCCATCGTCTCTGTGCAGGAGATAGTTGACTTTGCTAAACAGCTACCCGGCTTCCTGCAG
  CTCAGCCGGGAGGACCAGATTGCCCTGCTGAAGACCTCTGCGATCGAGGTGATGCTTCTG
  GAGACATCTCGGAGGTACAACCCTGGGAGTGAGAGTATCACCTTCCTCAAGGATTTCAGT
  TATAACCGGGAAGACTTTGCCAAAGCAGGGCTGCAAGTGGAATTCATCAACCCCATCTTC
  GAGTTCTCCAGGGCCATGAATGAGCTGCAACTCAATGATGCCGAGTTTGCCTTGCTCATT
  GCTATCAGCATCTTCTCTGCAGACCGGCCCAACGTGCAGGACCAGCTCCAGGTAGAGAGG
  CTGCAGCACACATATGTGGAAGCCCTGCATGCCTACGTCTCCATCCACCATCCCCATGAC
  CGACTGATGTTCCCACGGATGCTAATGAAACTGGTGAGCCTCCGGACCCTGAGCAGCGTC
  CACTCAGAGCAAGTGTTTGCACTGCGTCTGCAGGACAAAAAGCTCCCACCGCTGCTCTCT
  GAGATCTGGGATGTGCACGAATGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005693 unedited
  GGGGGNNNCNNTTTTTTNNNNNNNNGGTTCAGAATTGNATACGACTCCTATAGGCGGCCG
  CGNAATTCGCACCAGGTCCTGCTTGTGCTCAGCTCCAGCTCACTGGCTGGCCACCGAGAC
  TTCTGGACAGGAAACTGCACCATCCTCTTCTCCCAGCAAGGGGGCTCCAGAGACTGCCCA
  CCCAGGAAGTCTGGTGGCCTGGGGATTTGGACAGTGCCTTGGTAATGACCAGGGCTCCAG
  GAAGAGATGTCCTTGTGGCTGGGGGCCCCTGTGCCTGACATTCCTCCTGACTCTGCGGTG
  GAGCTGTGGAAGCCAGGCGCACAGGATGCAAGCAGCCAGGCCCAGGGAAGGCAGCAGCTG
  CATCCTCAGAGAGGAAGCCAGGATGCCCCACTCTGCTGGGGGTACTGCAGGGGTGGGGCT
  GGAGGCTGCAGAGCCCACAGCCCTGCTCACCAGGGCAGAGCCCCCTTCAGAACCCACAGA
  GATCCGTCCACAAAAGCGGAAAAAGGGGCCAGCCCCCANAATGCTGNGGAACGAGCTATG
  CAGCGTGTGTGGGGACAAGGCCTNCGGCTTCCACTACAATGTTCTGAGCTGCGAGGGCTG
  CAGGGGATTCTTCCGCCGCAGCGTCATCAAGGGAGCGCACTACATCTGCCACAGTGGCGG
  CCACTNGCCCATGGACACCTACATGCGTCGCAAGTGCCAGGAGTGTCCGCTTCGCAAATG
  CCGTCAGGCTGGCATGCCGGAGGAGTGTGTCCTGTCAGAAGAACAGATCCGCCTGAAGAA
  AACTGAGCCGCCAGAAGGAGGAACAGGCTCATGCCACATNCCTTTGCCCNNCCAGGCTTT
  TCTCACCCCNCCCAAANCCTGCCCCCAGCTCAGCCCGNAACAACTGGGCATGAATCGAGA
  AGCTCGTCCCTGCCCACCAACAGTGGTAACCGGNCGCTCCTTTTCTTGACCGGCTTCNGA
  TCCACGCCTGGGCCCATGGCACCAGATCCCATAACCGGNNAGCCCGTTACAAGCGCTTTG
  CCCCACTTACTGAGCTGGGCATCGGCTCTGGGCAGGAGGAAATTGAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005693 unedited
  CGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCT
  ATGATTTCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTGGTTTTTTTTTAACCCTTTGAC
  TCTCTTTTAATGCCACGGGAGGATCTCCTTGCCCAGCTCCCAGGAATGTTTGCCCTTCTC
  AGTCTGTTCCACTTCTAGGAGGCAGCCACCAGGCCTCAGCCATCCGGCCAAGAAAACAGA
  AAATATGGGGACAGAACAGTCATTCGTGCACATCCCAGATCTCAGAGAGCAGCGGTGGGA
  GCTTTTTGTCCTGCAGACGCAGTGCAAACACTTGCTCTGAGTGGACGCTGCTCAGGGTCC
  GGAGGCTCACCAGTTTCATTAGCATCCGTGGGAACATCAGTCGGTCATGGGGATGGTGGA
  TGGAGACGTAGGCATGCAGGGCTTCCACATATGTGTGCTGCAGCCTCTCTACCTGGAGCT
  GGTCCTGCACGTTGGGCCGGTCTGCAGAGAAGATGCTGATAGCAATGAGCAAGGCAAACT
  CGGCATCATTGAGTTGCAGCTCATTCATGGCCCTGGAGAACTCGAAGATGGGGTTGATGA
  ATTCCACTTGCAGCCCTGCTTTGGCAAAGTCTTCCNCGTTATAACTGANATCCTTGAGGA
  AGGTGATACTCTCACTCCCAGGGTTGTACCTCCGAGATGTCTCCAGAAGCATCACCTCGA
  TCGCAGAGGTCTTCAGCAGGGCAATCTGGTCCTNCCCGCTGAGCTGCAAGAAGCCGGGTA
  GCTGTTTAACAAATC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005693
• ORF Size: 1344 bp
• Insert Size: 1700
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_005693.1, NP_005684.1
• RefSeq Size: 1528
• RefSeq ORF: 1344
• Locus ID: 10062
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: PPAR signaling pathway
• Gene Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.