SMC3 (NM_005445) Human Untagged Clone

CAT#: SC116740

SMC3 (untagged)-Human structural maintenance of chromosomes 3 (SMC3)


  "NM_005445" in other vectors (4)

Reconstitution Protocol

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SMC3
Synonyms BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116740 sequence for NM_005445 edited (data generated by NextGen Sequencing)
ATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACAATTGTA
GATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAAC
TTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAG
CGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTGGAGATT
ATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGA
GTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGGTCACGAAAAATGAT
GTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATTGTTAAA
CAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGA
GAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAA
GAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAGAGATTA
CATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGA
CGAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCCAAACTTGAT
GAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGATGCTCAG
CAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAA
ATTTCAGCTATGAAAGAAGAAAAAGAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAG
CAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGCAATAGT
GAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAG
CAGAAAGAACTGGCAGAAACAGAACCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGA
GGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAGCAGGGT
CGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAG
TCTTTAGATCAGGCTATTAATGACAAGAAAAGACAGATTGCTGCTATACATAAGGATTTG
GAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGACCAGGAT
CTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAAT
AAGAAAGATGAACTACAAAGTGAAAGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAG
CAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGAGCAGCA
ACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGT
CGAAAAGGAATAAACCAGCATGTTCAAAATGGCTATCATGGTATTGTAATGAATAACTTT
GAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGGTTATTTTAT
CACATTGTTGATTCAGATGAAGTCAGCACGAAGATTTTAATGGAGTTTAATAAAATGAAT
CTTCCTGGAGAGGTTACTTTTCTGCCTCTTAACAAGTTAGATGTCAGGGATACAGCCTAT
CCTGAAACCAATGATGCTATTCCTATGATCAGCAAACTGAGGTACAATCCCAGATTTGAC
AAAGCTTTCAAACATGTGTTTGGAAAGACTCTTATTTGTCGTAGCATGGAAGTTTCAACC
CAGCTGGCCCGTGCTTTCACTATGGACTGTATTACTTTGGAAGGTGACCAAGTCAGCCAT
CGGGGTGCTCTAACTGGGGGTTATTATGACACAAGGAAGTCTCGACTTGAATTGCAAAAA
GATGTTAGAAAAGCAGAAGAAGAACTAGGTGAACTTGAAGCAAAGCTCAATGAAAACCTG
CGCAGAAATATTGAAAGGATTAATAATGAAATTGATCAGTTGATGAACCAAATGCAACAG
ATCGAGACCCAGCAAAGGAAATTTAAAGCATCTAGAGATAGCATATTATCAGAAATGAAG
ATGCTAAAAGAGAAGAGGCAGCAGTCAGAGAAAACCTTCATGCCTAAGCAACGTAGCTTA
CAGAGTTTGGAGGCAAGCTTGCATGCTATGGAGTCTACCAGAGAGTCATTGAAAGCAGAA
CTGGGAACTGATTTGCTTTCTCAACTGAGTTTGGAAGATCAGAAGAGAGTAGATGCACTG
AATGATGAGATTCGTCAACTTCAGCAGGAAAACAGACAGTTGCTAAATGAAAGAATTAAA
TTAGAAGGTATTATTACTCGAGTAGAGACTTATCTCAATGAGAATCTGAGAAAACGCTTG
GACCAAGTAGAACAGGAACTTAATGAGCTGAGAGAGACAGAAGGGGGTACTGTTCTCACA
GCCACAACATCAGAACTTGAAGCCATCAATAAAAGAGTAAAAGACACTATGGCACGATCA
GAAGATTTGGACAATTCCATTGATAAAACAGAAGCTGGAATTAAGGAGCTTCAGAAGAGT
ATGGAGCGCTGGAAAAATATGGAAAAAGAACATATGGATGCTATAAATCATGATACTAAA
GAACTGGAAAAGATGACAAATCGGCAAGGCATGCTATTGAAGAAGAAAGAAGAGTGTATG
AAGAAAATTCGAGAACTTGGATCACTTCCCCAGGAAGCATTTGAAAAGTACCAGACACTG
AGCCTCAAACAGTTGTTTCGAAAACTTGAGCAGTGCAACACAGAATTAAAGAAGTACAGC
CATGTTAACAAAAAGGCTTTGGATCAGTTTGTAAATTTCTCCGAGCAGAAAGAAAAGTTA
ATAAAGCGTCAAGAAGAGTTAGATAGGGGTTACAAATCGATCATGGAACTGATGAATGTA
CTTGAACTTCGGAAATATGAAGCTATTCAGTTAACTTTCAAACAGGTATCTAAGAACTTC
AGTGAAGTATTCCAGAAGTTAGTACCTGGTGGCAAAGCTACTTTGGTGATGAAGAAAGGA
GATGTGGAGGGCAGTCAGTCTCAAGATGAAGGAGAAGGGAGTGGTGAGAGTGAGAGGGGT
TCTGGCTCACAAAGCAGTGTCCCATCAGTTGACCAGTTTACTGGAGTTGGAATTAGGGTG
TCATTTACAGGAAAACAAGGTGAAATGAGAGAAATGCAACAGCTTTCAGGTGGACAGAAA
TCCTTGGTAGCCCTTGCTCTGATTTTTGCCATTCAGAAATGTGACCCGGCTCCATTTTAC
TTGTTTGATGAAATTGACCAGGCTCTGGATGCTCAGCACAGAAAGGCTGTGTCAGATATG
ATTATGGAACTTGCTGTACATGCTCAGTTTATTACAACTACTTTTAGGCCTGAACTGCTT
GAGTCAGCTGACAAATTCTATGGTGTAAAGTTCAGAAATAAGGTTAGTCATATTGATGTG
ATCACAGCAGAGATGGCCAAAGACTTTGTAGAAGATGATACCACACATGGTTAA

Clone variation with respect to NM_005445.3
3039 a=>g
>OriGene 5' read for NM_005445 unedited
TGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGGGAGGGGTCGCGTAG
GCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCCGGGGCAGGTCTCCTTCCAGGC
CAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGA
GATCAAACAATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGA
TCTGGAAAAAGTAACTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATC
TTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTG
CTTTTGTGGAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAG
TTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGG
TCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTT
ATTATATTGTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGAT
TAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCA
TCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAATCAATGGAGTTGTTAAAATACA
TTGAAGAGAGATTACATACTCTAGAGGAAGAAANGAAGAACTAGCTCAGTTNCAGAAGTG
GGATANAATGAGACGAGCCCTGGNATATACCATTTACAATCAGAACTTACGAGACTCGTG
CCAACTTGATGAGCTTTCTGCTAGCGAGAGACTAGTGGAGAANAATCCAGACATTAGAGA
TGCTCAGC
>OriGene 3' read for NM_005445 unedited
GCGGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTAGTCATAAAACCGATTATT
TAATTGAAGCTATAAAAAAGGTAGTATAAGTGATAAAATAATTAGGAAAGAATATTTAGC
ATGTTTCAAAACATTTAAAATAGGAGCAGAACATTTTACAAAAAGTTGTACAGGAAATTA
AATTCTTAAACTATCAGTACAAACATGACATTACAGAGTATCTTATAAAATACAAAGACA
AATATAAAAGGACTATGATGCTTTAAGTCTGAAAACTATTGGCCAAATATTTAGGTTTAA
ATTTACAGTTCCTGGGTATGAGAATCATATTACTATATACATCTCCCAAACCAGTAGGTA
GTATTTTCCAATTAACCATGTGTGGTATCATCTTCTACAAAGTCTTTGGCCATCTCTGCT
GTGATCACATCAATATGACTAACCTTATTTCTGAACTTTACACCATAGAATTTGTCAGCT
GACTCAAGCAGTTCAGGCCTAAAAGTAGTTGTAATAAACTGAGCATGTACAGCAAGTTCC
ATAATCATATCTGACACAGCCTTTCTGTGCTGAGCATCCAGAGCCTGGTCAATTTCATCA
AACAAGTAAAATGGAGCCGGGTCACATTTCTGAATGGCANAAATCAGAGCAAGGGCTACC
AAGGATTTCTGTCCACCTGAAAAGCTGTGCATTNCTCTCATTTCACCTTGTTTTCCTGGA
AATGACACCCTAATTCCAACTCCAGTAAACTGTTCAACTGATGGGACACTGCTTTGTGAG
CCANAACCCCTNTNNACTTTACCACTNCCTTTNTNCTTNATCTTGAAGACTGACTGGCCC
TCCACATTTCCTTTCTTTATCACCAAAGTAGCTTTGCCACCAGGTACTAACTTCTGGGAT
ACTTCACTTGAGTTCCTANATAACTGGTTTGAAGNTTACTGGAATACCTCATATTTCCGA
GGTTCAGGACCTTCCTA
Restriction Sites NotI-NotI     
ACCN NM_005445
ORF Size 3654 bp
Insert Size 4700
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_005445.3, NP_005436.1
RefSeq Size 4131
RefSeq ORF 3654
Locus ID 9126
Domains SMC_N, SMC_C
Protein Families Druggable Genome
Protein Pathways Cell cycle, Oocyte meiosis
Gene Summary This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

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