RAB8A (NM_005370) Human Untagged Clone

CAT#: SC116777

RAB8A (untagged)-Human RAB8A, member RAS oncogene family (RAB8A)


  "NM_005370" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol RAB8A
Synonyms MEL; RAB8
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116777 sequence for NM_005370 edited (data generated by NextGen Sequencing)
ATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGATCGGGGACTCGGGGGTGGGG
AAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAACTCCACTTTTATCTCCACC
ATAGGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGGCAAGAGAATTAAACTGCAG
ATATGGGACACAGCCGGTCAGGAACGGTTTCGGACGATCACAACGGCCTACTACAGGGGT
GCAATGGGCATCATGCTGGTCTACGACATCACCAACGAGAAGTCCTTCGACAACATCCGG
AACTGGATTCGCAACATTGAGGAGCACGCCTCTGCAGACGTCGAAAAGATGATACTCGGG
AACAAGTGTGATGTGAATGACAAGAGACAAGTTTCCAAGGAACGGGGAGAAAAGCTGGCC
CTCGACTATGGAATCAAGTTCATGGAGACCAGCGCGAAGGCCAACATCAATGTGGAAAAT
GCATTTTTCACTCTCGCCAGAGATATCAAAGCAAAAATGGACAAAAAATTGGAAGGCAAC
AGCCCCCAGGGGAGCAACCAGGGAGTCAAAATCACACCGGACCAGCAGAAGAGGAGCAGC
TTTTTCCGATGTGTTCTTCTGTGA

Clone variation with respect to NM_005370.4
>OriGene 5' read for NM_005370 unedited
CCTTGGCGACACTGCACCACAATTTTATATAGGGTGGNCGNGNAATTCGCACCAGGCTCT
CCTTTTTGCCGGCCAATGGGAGGTGCGCTTGGGATGATTAAGGATCCGCGCTCCGATCGC
CCCCTCCCAGGTCTCCCCGTGACTGGTGGGACGCAGGGGCGGGCGTCGGCCGCGGTGACG
CGCAGCGGGCCTGGAGCCAATAAGGGGCGGTTTTTTTTGCTGATGGACGGTGCTGGTGGC
CAGTGGAGAGGCGCTGGCTGCACTTACCGTCGGGGAGAGAGTGTCATATGGTGAAGACCT
ACGATTACCTGTTCAAGCTGCTGATGATCGGGGACTCGGTGGTGGGGAAGACCTGTGTCC
TGTTTCGATTCTCCGAGGACGTCTTCAACTCCACTTTTATCTCCACTATAGGAATTGATT
TTAAAATTAGGAGCATAGAGCTCGATGGCAAAAGAATTAAACTGTAGATATGGGACACAG
CTGGTCTGGAACGGTTTCGGACGATCACACTGGACTACTACAGGGGTGCAATGGGCATCA
TGTTGGTCTACGAAATTATCAACGTAGAGTTCTTCCCCAACATCCGGAACTGGATTTCAA
CATTGAGGAGTCCGCCTCTGCAGACGTCTTAAAGATGAATCCTCGGCACCATCTGTGACG
TCACTGACCAACAAACATGTTTCTTAGGACACGGTGAAAAACGCTGGGTTTTTAATTATG
GTATCAGTTTATGGTGACCACCTCCAAGGTCCCACATTACTGTGGCACAGTGATTTTTCA
TTTCTTTTCTCAGATATCATAGCTAATAGGCCCAAAAATTGGGAAGTACCATCCTCCTAG
GGGTGCCACCTTGGAGTTCAAACTTCCATGAACCTCCTACAAAGGAGCTCTTTTTTCACA
GTGTTCTTTTCGTAGCACCACCCTTATTTTGCGCTCCCCACCCTAATGATTGCCTCGTT
>OriGene 3' read for NM_005370 unedited
TGAGGCAGGGGTACACAGGGCATGCCACCCGGGTATCTGTTCAGGAAAACAGCTATGACC
GCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGACTTTAAA
ATGAGCTTTAATTTGTTTGTTTTCCTTAAGTGCATTTATCGATGTAAACAGAGCATGTTA
GATATTTTTGGGGAGAGCAGACTATTGCTGATATGTTGGTTTTAATTCAAAAGAAACGAT
GATGCCTATGGTTTGGATTGACAGCCGCTTAAGGAGGAAAAAAAAAAAAAGAAAGAAAAA
AAGAAAGGGGTGGTGACACCCCCCTGGCGTGGTTGACCTGGTCCCAGTCGCAGTCCCTAT
GGGACAGCAGATCTGTCAAAACAGAACCCAATGATGACGGCTGAAAATCAAGCCAGACTG
CTGTGCGGTCAGCTTGCCGCCGTGGAATGCCTTGTGTCTTGGCCATGTCCAGCCAAGGGT
ACAACGTGCTTGTTCCCGATCACCCAGGTTTGCCATTGGAAGTCAAAGACAGAATCGCTT
CATGGCACTTCAGATGTGGAAAAATAAAAATCTCATCTAAAAAGAACGTCCGATTTGGAG
ATAGCGGGAGGACACGAAGGAGTGGGGGCCATTTTGGTGCTGAGAGGAGGGTGCCCCAAC
TTCAAGAAGACCATGTGACGGCTGTGGTTGTTTTCGGGGTCATTTGAAACACACACAGCG
TCCCCTTGATGCTCGATGGGGACCGCAAACGGGCCTGCANACCTAACCCCTGTCTGTGGA
CAAGAGAGGCTGCTCAAGGCTTCTTTCCTTCTAATGCTTTACACAGGATTCCCTCTTTGT
GGCTTTCTTTGGTTTACAATAAAAAAAG
Restriction Sites NotI-NotI     
ACCN NM_005370
ORF Size 624 bp
Insert Size 2300
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_005370.4, NP_005361.2
RefSeq Size 2194
RefSeq ORF 624
Locus ID 4218
Domains ras, RAN, RAS, RHO, RAB, ARF
Protein Families Druggable Genome, Transcription Factors
Gene Summary The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]

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