RAB8A (NM_005370) Human Untagged Clone

CAT#: SC320702

RAB8A (untagged)-Human RAB8A, member RAS oncogene family (RAB8A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RAB8A
• Synonyms: MEL; RAB8
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005370.4 GCTCGGTGCTGATGGACGGTGCTGGTGGCCAGTGGAGAGGCGCTGGCCGCACTTCCCGTC
  GGGGAGAGAGTGTAATATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGATCGG
  GGACTCGGGGGTGGGGAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAACTC
  CACTTTTATCTCCACCATAGGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGGCAA
  GAGAATTAAACTGCAGATATGGGACACAGCCGGTCAGGAACGGTTTCGGACGATCACAAC
  GGCCTACTACAGGGGTGCAATGGGCATCATGCTGGTCTACGACATCACCAACGAGAAGTC
  CTTCGACAACATCCGGAACTGGATTCGCAACATTGAGGAGCACGCCTCTGCAGACGTCGA
  AAAGATGATACTCGGGAACAAGTGTGATGTGAATGACAAGAGACAAGTTTCCAAGGAACG
  GGGAGAAAAGCTGGCCCTCGACTATGGAATCAAGTTCATGGAGACCAGCGCGAAGGCCAA
  CATCAATGTGGAAAATGCATTTTTCACTCTCGCCAGAGATATCAAAGCAAAAATGGACAA
  AAAATTGGAAGGCAACAGCCCCCAGGGGAGCAACCAGGGAGTCAAAATCACACCGGACCA
  GCAGAAGAGGAGCAGCTTTTTCCGATGTGTTCTTCTGTGAGGAACACCGCCTTACTCTGA
  GCCTCGCTCAGCCCAGCTGACTGTGCCTGTTCTGAGTGAGCCCCTCACTCAGCCGGGGCC
  CTCCCACCTCCAACGCCCCGCCCACGCCGCGGCCACCGGGCCCACGGCCACCAGAATGCA
  ATTGAGAAATCGTTTATTTTAGTAACTGTCTGATCTTTTTCAACTTTGGAGATGGAATAA
  GTTAAAAATTTGCTATTTTTCCTGTAACATCTGCTGAACGGGCCCACCCACACGTTGTAT
  ATTCAGAGAGAGAGAGGGAGTCAAGGTGTGACCGTCGACCACAGCCAGTGTCAGGCCTCT
  GCCTCTGGGCCTTTGCTTTGTGGCCTCACTGCAACACAAAGCTCCACCAGGAGGCTGGTT
  CACGTCCCCTACCACGGAAGCGAGGTCCCAGAAGGCCAGCGGTGGTTCCAGGAGCAACAG
  CTCCCAAACCCTGAGCAAGGCAACCGATCGCCAGGACCAGGAAGCATCACCCAGGAGATT
  TGGCGCCCACTTCCACCTCTTCTCTCAGTTTTGGACAAGTGACAAACCATTTTGCCCCCT
  CACTCTTCTTTTTTAACTGTTAAACCAAAGGAAAGCACAAATGAAGGAAATCCTGTGTAA
  AGCATTGAGAAGGAAAGAAGCCTGGAGCAGCCTCTCCTGTCCACAGCCAGGGGTTAGGTC
  TGCAGGCCCGTCTGCGGTCCCCATCGAGCATCAAGGGGACGCTGTGTGTGCTGCAAGTGA
  CCCCGAAAACAACCACAGCCGTCACATGGTCCTCCTGAAGTTGGGGCACCCTCCTCTCAG
  CACCAAAATGGCCCCCACTCCTTCGTGTCCTCCCGCTATCTCCAAATCGGACGTTCTTTC
  TAGCTGAGATTTTTATTTTTCCACATCTGTAGTGCCATGAAGCGATTCTGTCTTTGACTT
  CCAATGGCAAACCTGGGTGATCGGGAACAAGCACGTTGTACCCTTGGCTGGACATGGCCA
  AGACACAAGGCATTCCACGGCGGCAAGCTGACCGCACAGCAGTCTGGCTTGATTTTCAGC
  CGTCATCATTGGGTTCTGTTTTGACAGCTCTGCTGTCCCATAGGGACTGCGACTGGGACC
  AGGTCAACCACGCCAGGGGGGTGTCACCAGCCTTTTCTTTTTTTCTTTCTTTTTTTTTTT
  TTCCTCCTTAAGCTGCTGTCAATCCAAACCATTGGCATCATCGTTTCTTTTCAATTAAAA
  CCAACATATCAGCAATAGTCTGCTCTCCCCGGGAATCTCTAACATGCTCTGTTTACATCG
  ATAAATGCACTTAAGGAAAACAAACAAATTAAAGCTCATCTTAAAGTCCAAAAAAAAAAA
  AAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005370.4 unedited
  CCGATGTGTATACGACTCCTATAGGGCGGGAGGAAACCGGCACCAGGGCTCGGTGCTGAT
  GGACGGAGCTGGTGGCCAGTGGAGAGGCGCTGGCCGCACTTCCCGTCGGGGAGAGAGTGT
  AATATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGATCGGGGACTCGGGGGTG
  GGGAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAACTCCACTTTTATCTCC
  ACCATAGGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGGCAAGAGAATTAAACTG
  CAGATATGGGACACAGCCGGTCAGGAACGGTTTCGGACGATCACAACGGCCTACTACAGG
  GGTGCAATGGGCATCATGCTGGTCTACGACATCACCAACGAGAAGTCCTTCGACAACATC
  CGGAACTGGATTCGCAACATTGAGGAGCACGCCTCTGCAGACGTCGAAAAGATGATACTC
  GGGAACAAGTGTGATGTGAATGACAAGAGACAAGTTTCCAAGGAACGGGGAGAAAAGCTG
  GCCCTCGACTATGGAATCAAGTTCATGGAGACCCAGCGCGAAGGCCACCATCAATGTGGA
  AAATGCATTTTTCACCTCTCGCCAGAGATATCCAAGCAAAATGGACAAAAAATTGGAAAG
  GCAACAGCCCCCAGGGGAGCAACCCAGGGAGTCAAAATTCACACCGGGACCCATCCAGAG
  AGGAGCAGCTTTTTCCCGATGTGTTCCTTCTGTTGAGGAACACGGCCTTACTCTTGAGCC
  CTCGGCTCAGCCCAACCTGACTGTGCCTGGTTCTGAGTGTGAGTCCCTTACTCAGCCGGG
  GGCTTTCAACTTCAAGGCCCGCACACGCCTGGGGCCACCCGGGGCCCACGGGGCGCACGA
  AAGCAGTTGAGAACGGATATTTAAATACTGTCTGAATCTTTTCACTTTGGGAATATGCGA
  TCATAGGTAGAAAGTGTAGGACTATTATATTCTCAATATACTCCTGTCTGTCG
• Restriction Sites: Please inquire
• ACCN: NM_005370
• ORF Size: 624 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005370.4, NP_005361.2
• RefSeq Size: 2194
• RefSeq ORF: 624
• Locus ID: 4218
• Domains: ras, RAN, RAS, RHO, RAB, ARF
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]