RAB8A (NM_005370) Human Untagged Clone

CAT#: SC320702

RAB8A (untagged)-Human RAB8A, member RAS oncogene family (RAB8A)


  "NM_005370" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol RAB8A
Synonyms MEL; RAB8
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for NM_005370.4 GCTCGGTGCTGATGGACGGTGCTGGTGGCCAGTGGAGAGGCGCTGGCCGCACTTCCCGTC
GGGGAGAGAGTGTAATATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGATCGG
GGACTCGGGGGTGGGGAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAACTC
CACTTTTATCTCCACCATAGGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGGCAA
GAGAATTAAACTGCAGATATGGGACACAGCCGGTCAGGAACGGTTTCGGACGATCACAAC
GGCCTACTACAGGGGTGCAATGGGCATCATGCTGGTCTACGACATCACCAACGAGAAGTC
CTTCGACAACATCCGGAACTGGATTCGCAACATTGAGGAGCACGCCTCTGCAGACGTCGA
AAAGATGATACTCGGGAACAAGTGTGATGTGAATGACAAGAGACAAGTTTCCAAGGAACG
GGGAGAAAAGCTGGCCCTCGACTATGGAATCAAGTTCATGGAGACCAGCGCGAAGGCCAA
CATCAATGTGGAAAATGCATTTTTCACTCTCGCCAGAGATATCAAAGCAAAAATGGACAA
AAAATTGGAAGGCAACAGCCCCCAGGGGAGCAACCAGGGAGTCAAAATCACACCGGACCA
GCAGAAGAGGAGCAGCTTTTTCCGATGTGTTCTTCTGTGAGGAACACCGCCTTACTCTGA
GCCTCGCTCAGCCCAGCTGACTGTGCCTGTTCTGAGTGAGCCCCTCACTCAGCCGGGGCC
CTCCCACCTCCAACGCCCCGCCCACGCCGCGGCCACCGGGCCCACGGCCACCAGAATGCA
ATTGAGAAATCGTTTATTTTAGTAACTGTCTGATCTTTTTCAACTTTGGAGATGGAATAA
GTTAAAAATTTGCTATTTTTCCTGTAACATCTGCTGAACGGGCCCACCCACACGTTGTAT
ATTCAGAGAGAGAGAGGGAGTCAAGGTGTGACCGTCGACCACAGCCAGTGTCAGGCCTCT
GCCTCTGGGCCTTTGCTTTGTGGCCTCACTGCAACACAAAGCTCCACCAGGAGGCTGGTT
CACGTCCCCTACCACGGAAGCGAGGTCCCAGAAGGCCAGCGGTGGTTCCAGGAGCAACAG
CTCCCAAACCCTGAGCAAGGCAACCGATCGCCAGGACCAGGAAGCATCACCCAGGAGATT
TGGCGCCCACTTCCACCTCTTCTCTCAGTTTTGGACAAGTGACAAACCATTTTGCCCCCT
CACTCTTCTTTTTTAACTGTTAAACCAAAGGAAAGCACAAATGAAGGAAATCCTGTGTAA
AGCATTGAGAAGGAAAGAAGCCTGGAGCAGCCTCTCCTGTCCACAGCCAGGGGTTAGGTC
TGCAGGCCCGTCTGCGGTCCCCATCGAGCATCAAGGGGACGCTGTGTGTGCTGCAAGTGA
CCCCGAAAACAACCACAGCCGTCACATGGTCCTCCTGAAGTTGGGGCACCCTCCTCTCAG
CACCAAAATGGCCCCCACTCCTTCGTGTCCTCCCGCTATCTCCAAATCGGACGTTCTTTC
TAGCTGAGATTTTTATTTTTCCACATCTGTAGTGCCATGAAGCGATTCTGTCTTTGACTT
CCAATGGCAAACCTGGGTGATCGGGAACAAGCACGTTGTACCCTTGGCTGGACATGGCCA
AGACACAAGGCATTCCACGGCGGCAAGCTGACCGCACAGCAGTCTGGCTTGATTTTCAGC
CGTCATCATTGGGTTCTGTTTTGACAGCTCTGCTGTCCCATAGGGACTGCGACTGGGACC
AGGTCAACCACGCCAGGGGGGTGTCACCAGCCTTTTCTTTTTTTCTTTCTTTTTTTTTTT
TTCCTCCTTAAGCTGCTGTCAATCCAAACCATTGGCATCATCGTTTCTTTTCAATTAAAA
CCAACATATCAGCAATAGTCTGCTCTCCCCGGGAATCTCTAACATGCTCTGTTTACATCG
ATAAATGCACTTAAGGAAAACAAACAAATTAAAGCTCATCTTAAAGTCCAAAAAAAAAAA
AAAAAAAA
>OriGene 5' read for NM_005370.4 unedited
CCGATGTGTATACGACTCCTATAGGGCGGGAGGAAACCGGCACCAGGGCTCGGTGCTGAT
GGACGGAGCTGGTGGCCAGTGGAGAGGCGCTGGCCGCACTTCCCGTCGGGGAGAGAGTGT
AATATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGATCGGGGACTCGGGGGTG
GGGAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAACTCCACTTTTATCTCC
ACCATAGGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGGCAAGAGAATTAAACTG
CAGATATGGGACACAGCCGGTCAGGAACGGTTTCGGACGATCACAACGGCCTACTACAGG
GGTGCAATGGGCATCATGCTGGTCTACGACATCACCAACGAGAAGTCCTTCGACAACATC
CGGAACTGGATTCGCAACATTGAGGAGCACGCCTCTGCAGACGTCGAAAAGATGATACTC
GGGAACAAGTGTGATGTGAATGACAAGAGACAAGTTTCCAAGGAACGGGGAGAAAAGCTG
GCCCTCGACTATGGAATCAAGTTCATGGAGACCCAGCGCGAAGGCCACCATCAATGTGGA
AAATGCATTTTTCACCTCTCGCCAGAGATATCCAAGCAAAATGGACAAAAAATTGGAAAG
GCAACAGCCCCCAGGGGAGCAACCCAGGGAGTCAAAATTCACACCGGGACCCATCCAGAG
AGGAGCAGCTTTTTCCCGATGTGTTCCTTCTGTTGAGGAACACGGCCTTACTCTTGAGCC
CTCGGCTCAGCCCAACCTGACTGTGCCTGGTTCTGAGTGTGAGTCCCTTACTCAGCCGGG
GGCTTTCAACTTCAAGGCCCGCACACGCCTGGGGCCACCCGGGGCCCACGGGGCGCACGA
AAGCAGTTGAGAACGGATATTTAAATACTGTCTGAATCTTTTCACTTTGGGAATATGCGA
TCATAGGTAGAAAGTGTAGGACTATTATATTCTCAATATACTCCTGTCTGTCG
Restriction Sites Please inquire     
ACCN NM_005370
ORF Size 624 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Reference Data
RefSeq NM_005370.4, NP_005361.2
RefSeq Size 2194
RefSeq ORF 624
Locus ID 4218
Domains ras, RAN, RAS, RHO, RAB, ARF
Protein Families Druggable Genome, Transcription Factors
Gene Summary The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]

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