APLP1 (NM_005166) Human Untagged Clone

CAT#: SC116888

APLP1 (untagged)-Human amyloid beta (A4) precursor-like protein 1 (APLP1), transcript variant 2


  "NM_005166" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol APLP1
Synonyms APLP
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116888 sequence for NM_005166 edited (data generated by NextGen Sequencing)
ATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTG
CCGCTGCTGCTGCCACTATTGCTGCTGCTTCTGCGCGCGCAGCCCGCCATCGGGAGCCTG
GCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGC
GGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGC
TCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCG
GAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGC
GGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGC
CTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCAC
CAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCC
TGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGAT
CGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGG
ACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCT
GAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCT
CCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTG
GTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATG
CCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGT
AGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAG
AACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACT
CTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTC
ATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAG
GCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAG
CAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAG
AAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTG
AATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAA
ATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCT
GGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCC
ATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATG
AACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTC
CACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAG
GCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATG
CTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGAC
CCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAAC
CCCACTTACCGCTTCCTGGAGGAACGACCCTGA

Clone variation with respect to NM_005166.3
>OriGene 5' read for NM_005166 unedited
CCGCACTTCTATAGGCGGCCGCGCAATTCGCACGAGGCATGGGGCCCGCCAGCCCCGCTG
CTCGCGGTCTAAGGGGGCGCCCGGGCCAGCCGCCGCTGCCGCTGCTGCTGCCACTATTGC
TGCTGCTTCTGCGCGCGCAGCCCGCCATCGGGAGCCTGGCCGGTGGGAGCCCCGGCGCGG
CCGAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGG
ACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACC
CGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGG
AGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCT
GCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTG
AGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTG
AGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCC
TGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATG
TGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCA
CCCGTCCTGGCCCCCGGNGAGCANAGTANAGGGGGCTGANGACGANGAAGAGGAGAATCC
TTCCACAGCCAGTAGATGATACTTCGTGGAGCCTCCGCAGCTGAAAAGAGAGGGNAAACG
GTCCCACCCCAGCTCCATACCTNGCAGTGGTCGGNAAGTCACTCCACCCGAGCCACAGAA
GGGGGTGAATATTACTTTGGCTGCCTGGGAATCATGGACCCAGGGGTCCTGAGGGCANAT
GGACTNAAGGACCTAGAGCCCT
>OriGene 3' read for NM_005166 unedited
ACTTCCAGGGCCGGNAAAGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTC
AGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGGT
AGGGAAGAGGACTTTATTGGGATGTTAGTAGGGAAACATGAGAGGGTGAATTCCAGGGAA
TAGACACTAGGACCAAGGTGGCGGTCACCTTAAAGAGCCATAAATAAACTTAAAAAATAA
ATTAAGGTGAGGAGGTGCCACGTGGGGAGGCTGCTGGGACTATCTGGGAATTCTTAGGGA
TGGAATTTTGGAATTGGAAAGGGGAAATAAGAATTTCCAGCCGTCTCACAAAAGGGTGTG
AAATGATCACTTCAAGACTCCCTGCTGCCCTAGGCTGGGAGTTGGGGTTCTGGGGCTCCA
GGAAGAGGGGAGGTCTGGGCTCGGCTGAAGGGGTGAAGGGGGCCGGGTCAGGGTCGTTCC
TCCAGGAAGCGGTAAGTGGGGTTCTCATAGCCGTGCCGCTGCAGTTCGCGGAGCTGCTGC
TCCTCCAGGGTCAGCATGGGGTCCACCTCCACCACGCCATGGCTGATAGCCCCGTNAGGC
TTCTTCCTGCGCAGGAGCAGCATGGAGAGGACGATGAGGGAGCCTCCGCCCGCTCCCATG
ATCAGCAGACCCGACACAGCCTCACGGGACACCCCTGTCCCAGCTGGTGCCAGCTCATCC
CTCTGAATCTNCGATGAGTGGGAAAGGGAAACCCCTTGGAACAGACGCATTCACCTTTCG
CTATACTGGTCCAGCGGGTTCATCTTCTCTTCTCAGGGGATGCGCATCTTGTTCTGTGAC
CTTTNGGAGGTAATNGGGGGGGGGTCATCTTGATCTGGAGCTGCACCCACCTTGNCTCCT
GTGCCCAGGGGGAGGGGCTTCATACTGAACCAGTGTGTTAANGGAAAGGGAGCTTTGGTT
TTTTGGGCGATCTCACACAGNNGNNGGNNTTNT
Restriction Sites NotI-NotI     
ACCN NM_005166
Insert Size 2440 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005166.3, NP_005157.1
RefSeq Size 2447 bp
RefSeq ORF 1953 bp
Locus ID 333
Cytogenetics 19q13.12
Domains A4_EXTRA
Protein Families Druggable Genome, Transmembrane
Gene Summary 'This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

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