LONP1 (NM_004793) Human Untagged Clone

CAT#: SC117111

LONP1 (untagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LONP1
• Synonyms: CODASS; hLON; LON; LonHS; LONP; PIM1; PRSS15
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_004793, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGC
  TGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCAGCGGACCTGCGA
  CGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGGGCCAATGGCGGGGGTTTTGGGAA
  GCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAG
  CCGGCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGAT
  CCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAG
  ATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATG
  TCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCA
  CACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGA
  CACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACA
  AGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGA
  GCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCAC
  GAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCA
  TTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAA
  CCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTG
  GAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCA
  AGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCA
  GGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAG
  TTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCA
  AGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTC
  CATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGAC
  CACTACGGCATGGAGGACGTCAAGAAACGCATCCTGGAGTTCATTGCCGTTAGCCAGCTCCGCGGCTCCA
  CCCAGGGCAAGATCCTCTGCTTCTATGGCCCCCCTGGCGTGGGTAAGACCAGCATTGCTCGCTCCATCGC
  CCGCGCCCTGAACCGAGAGTACTTCCGCTTCAGCGTCGGGGGCATGACTGACGTGGCTGAGATCAAGGGC
  CACAGGCGGACCTACGTGGGCGCCATGCCCGGGAAGATCATCCAGTGTTTGAAGAAGACCAAGACGGAGA
  ACCCCCTGATCCTCATCGACGAGGTGGACAAGATCGGCCGAGGCTACCAGGGGGACCCGTCGTCGGCACT
  GCTGGAGCTGCTGGACCCAGAGCAGAATGCCAACTTCCTGGACCACTACCTGGACGTGCCCGTGGACTTG
  TCCAAGGTGCTGTTCATCTGCACGGCCAACGTCACGGACACCATCCCCGAGCCGCTGCGAGACCGTATGG
  AGATGATCAACGTGTCGGGCTACGTGGCCCAGGAGAAGCTGGCCATTGCGGAGCGCTACCTGGTGCCCCA
  GGCTCGCGCCCTGTGTGGCTTGGATGAGAGCAAGGCCAAGCTGTCATCGGACGTGCTGACGCTGCTCATC
  AAGCAGTACTGCCGCGAGAGCGGTGTCCGCAACCTGCAGAAGCAAGTGGAGAAGGTGTTACGGAAATCGG
  CCTACAAGATTGTCAGCGGCGAGGCCGAGTCCGTGGAGGTGACGCCCGAGAACCTGCAGGACTTCGTGGG
  GAAGCCCGTGTTCACCGTGGAGCGCATGTATGACGTGACACCGCCCGGCGTGGTCATGGGGCTGGCCTGG
  ACCGCAATGGGAGGCTCCACGCTGTTTGTGGAGACATCCCTGAGACGGCCACAGGACAAGGATGCCAAGG
  GTGACAAGGATGGCAGCCTGGAGGTGACAGGCCAGCTGGGGGAGGTGATGAAGGAGAGCGCCCGCATAGC
  CTACACCTTCGCCAGAGCCTTCCTCATGCAGCACGCCCCCGCCAATGACTACCTGGTGACCTCACACATC
  CACCTGCATGTGCCCGAGGGCGCCACCCCCAAGGACGGCCCAAGCGCAGGCTGCACCATCGTCACGGCCC
  TGCTGTCCCTGGCCATGGGCAGGCCTGTCCGGCAGAATCTGGCCATGACTGGCGAAGTCTCCCTCACGGG
  CAAGATCCTGCCTGTTGGTGGCATCAAGGAGAAGACCATTGCGGCCAAGCGCGCAGGGGTGACGTGCATC
  GTCCTGCCAGCCGAGAACAAGAAGGACTTCTACGACCTGGCAGCCTTCATCACCGAGGGCCTGGAGGTGC
  ACTTCGTGGAACACTACCGGGAGATCTTCGACATCGCCTTCCCGGACGAGCAGGCAGAGGCGCTGGCCGT
  GGAACGGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004793 unedited
  GTAACGTCAAAATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACCAGTGGCG
  GCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCG
  ATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGC
  CAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGG
  GGCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGC
  GAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGGGGGGCAGCGCGGGC
  GCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCG
  CACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATC
  GAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCT
  TATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTG
  GATGAAATCTACCACACGGNGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGA
  CAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGT
  GGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTNCAAGCGGGG
  CAAGAAGGAGGCGGAAGACGAGCTGAGCGCCGGCACCCGGCGGAGCTGGCGATGGAGCCC
  ACCCTGAGCTCCCGGCTGAGTGCTCAGGTTGGAGGTAGAAAACGTTGTCCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004793 unedited
  CTTGGACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTACGGCAAAGGACTTTAATCATTAAATACCTTTTAT
  GCCACACTTTGATTAACCCCACTGAGGCCCCTGGGATCTGGGTCACTGGACCAAACTGCT
  CGCTCGGGGGCTCCACTGCCAGGTCCGGGCCCCCTCCCCACAGCGCTAATTTTTGGCCCA
  AACAGGGCCTGACATCCCCCCCCTGCAGTCCCGGGGGGGCCGTCACCGTTCCACGGCCAG
  CGCCTTTGCCTGTTTTTCCGGAAAGGCAATGTCAAAAATCTCCCGGTAGTGTTCCACAAA
  GGGCACCTCCAGGCCCTCGGGGATAAAGGCTGCCAGGTCAAAAAAATCCTTTTTGTTTTC
  GGTTGGCAGGACAATGCACGTCACCCCTGCCCCCTTGGCCGAAATGGTTTTTTCCTTGAT
  GCCACCAACAGGCAGGATCTTGCCCGGGAGGGAAACTTCCCCAGTCATGGCCAAATTTTG
  CCGGACAGGCCTGCCCATGGCCAGGGACAACAGGGCCGTAACAATGGGGCAACCTGCCCT
  TGGGCCGTCCTTGGGGGGGGCCCCCTCGGGCCATGCAGGGGGATGTGTGAGGCCCCAGGT
  ATTATTGGCGGGGGGCGTGCTGCATAGAGGAGGCTCTGGCCAAGGTTAGGCTATGCGGGC
  GCTTTCCTTATCACCCCCCCAGGTGGCCTGTCACTCCAGCTGGCATCCTTGCACCCTTGC
  ATCCTTGGCTTGGGGCCGTTAAAGGGATGCCCCCAAAACGGGGGAACCTCCCTTGGNGGT
  CCGGCCAACCCATACACCCGGGGGGGGGTGACATTTAAATGCCCTCCCGGGGAACCGGCT
  CCCCAAAAACCCGGGGTTTTTGGGCGACCTCCCAGGTCTGCCTCGCGGTGAATTTTTAGG
  CCTATTCCAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004793
• ORF Size: 2814 bp
• Insert Size: 3460
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_004793.1, NP_004784.1
• RefSeq Size: 3221
• RefSeq ORF: 2814
• Locus ID: 9361
• Domains: LON, AAA, AAA
• Protein Families: Druggable Genome, Protease
• Gene Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
  Transcript Variant: This variant (1) encodes the longest isoform (1).