LONP1 (NM_004793) Human Untagged Clone

CAT#: SC320641

LONP1 (untagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein


  "NM_004793" in other vectors (8)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol LONP1
Synonyms CODASS; hLON; LON; LonHS; LONP; PIM1; PRSS15
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for NM_004793.2 GGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGC
TGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGT
TGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCC
CGGCAATTGGGGGCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCAT
TCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGGGGG
GCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCG
ATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTA
TCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTC
TCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGG
TCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGG
ACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGAC
AGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGT
CAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGG
CGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTG
TCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGA
CCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGC
AGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCA
CCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGC
TGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCC
TGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGC
AGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGG
AGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGG
ACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCC
GCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGG
ACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGA
AACGCATCCTGGAGTTCATTGCCGTTAGCCAGCTCCGCGGCTCCACCCAGGGCAAGATCC
TCTGCTTCTATGGCCCCCCTGGCGTGGGTAAGACCAGCATTGCTCGCTCCATCGCCCGCG
CCCTGAACCGAGAGTACTTCCGCTTCAGCGTCGGGGGCATGACTGACGTGGCTGAGATCA
AGGGCCACAGGCGGACCTACGTGGGCGCCATGCCCGGGAAGATCATCCAGTGTTTGAAGA
AGACCAAGACGGAGAACCCCCTGATCCTCATCGACGAGGTGGACAAGATCGGCCGAGGCT
ACCAGGGGGACCCGTCGTCGGCACTGCTGGAGCTGCTGGACCCAGAGCAGAATGCCAACT
TCCTGGACCACTACCTGGACGTGCCCGTGGACTTGTCCAAGGTGCTGTTCATCTGCACGG
CCAACGTCACGGACACCATCCCCGAGCCGCTGCGAGACCGTATGGAGATGATCAACGTGT
CGGGCTACGTGGCCCAGGAGAAGCTGGCCATTGCGGAGCGCTACCTGGTGCCCCAGGCTC
GCGCCCTGTGTGGCTTGGATGAGAGCAAGGCCAAGCTGTCATCGGACGTGCTGACGCTGC
TCATCAAGCAGTACTGCCGCGAGAGCGGTGTCCGCAACCTGCAGAAGCAAGTGGAGAAGG
TGTTACGGAAATCGGCCTACAAGATTGTCAGCGGCGAGGCCGAGTCCGTGGAGGTGACGC
CCGAGAACCTGCAGGACTTCGTGGGGAAGCCCGTGTTCACCGTGGAGCGCATGTATGACG
TGACACCGCCCGGCGTGGTCATGGGGCTGGCCTGGACCGCAATGGGAGGCTCCACGCTGT
TTGTGGAGACATCCCTGAGACGGCCACAGGACAAGGATGCCAAGGGTGACAAGGATGGCA
GCCTGGAGGTGACAGGCCAGCTGGGGGAGGTGATGAAGGAGAGCGCCCGCATAGCCTACA
CCTTCGCCAGAGCCTTCCTCATGCAGCACGCCCCCGCCAATGACTACCTGGTGACCTCAC
ACATCCACCTGCATGTGCCCGAGGGCGCCACCCCCAAGGACGGCCCAAGCGCAGGCTGCA
CCATCGTCACGGCCCTGCTGTCCCTGGCCATGGGCAGGCCTGTCCGGCAGAATCTGGCCA
TGACTGGCGAAGTCTCCCTCACGGGCAAGATCCTGCCTGTTGGTGGCATCAAGGAGAAGA
CCATTGCGGCCAAGCGCGCAGGGGTGACGTGCATCGTCCTGCCAGCCGAGAACAAGAAGG
ACTTCTACGACCTGGCAGCCTTCATCACCGAGGGCCTGGAGGTGCACTTCGTGGAACACT
ACCGGGAGATCTTCGACATCGCCTTCCCGGACGAGCAGGCAGAGGCGCTGGCCGTGGAAC
GGTGACGGCCACCCCGGGACTGCAGGCGGCGGATGTCAGGCCCTGTCTGGGCCAGAACTG
AGCGCTGTGGGGAGCGCGCCCGGACCTGGCAGTGGAGCCACCGAGCGAGCAGCTCGGTCC
AGTGACCCAGATCCCAGGGACCTCAGTCGGCTTAATCAGAGTGTGGCATAGAAGCTATTT
AATGATTAAAGTCATTTGCAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_004793.2 unedited
GCCAATTGTAATACGACTCCTATAGGGCGGCCGGGAATCGGCACGAGGGGGCTATGGCGG
CGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGA
TGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCC
AGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGG
GCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCG
AGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGGGGGGCAGCGCGGGCG
CCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGC
ACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCG
AGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTT
ATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGG
ATGAAAATCTACCAACACGGAGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGA
CAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCACCAGACAGCTGGAAGT
TGAGCCCGAGGAGCCGGAAGGCGGAGAACAAGCACAAGCCCCGCAGAACGTTCAACAGCG
GGCATAGAACGGAGGCGGAAGACGAAGCTGGAAGCCGCCAGGCACCCGGCGGAGCTTGCC
GATTGGAGCCCACCCTGAACCTCCCGGCCTTGAGTTTGCTTATTGTGGTGAGTTCAAGAC
AGCGTTTGTTCGCAGAGGTACTTTCCAGGTCACGGAAGGATGTGTAAAGCCTTGAACTGC
AGAATCTTGGAGAACAATCGCCGAAACATCTATGCCTTTGAACCTCTCTTTTTACGCGTA
Restriction Sites Please inquire     
ACCN NM_004793
ORF Size 2880 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Reference Data
RefSeq NM_004793.2, NP_004784.2
RefSeq Size 3111
RefSeq ORF 2880
Locus ID 9361
Domains LON, AAA, AAA
Protein Families Druggable Genome, Protease
Gene Summary This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Transcript Variant: This variant (1) encodes the longest isoform (1).

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