LONP1 (NM_004793) Human Untagged Clone

CAT#: SC320641

LONP1 (untagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LONP1
• Synonyms: CODASS; hLON; LON; LonHS; LONP; PIM1; PRSS15
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004793.2 GGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGC
  TGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGT
  TGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCC
  CGGCAATTGGGGGCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCAT
  TCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGGGGG
  GCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCG
  ATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTA
  TCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTC
  TCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGG
  TCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGG
  ACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGAC
  AGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGT
  CAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGG
  CGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTG
  TCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGA
  CCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGC
  AGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCA
  CCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGC
  TGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCC
  TGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGC
  AGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGG
  AGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGG
  ACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCC
  GCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGG
  ACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGA
  AACGCATCCTGGAGTTCATTGCCGTTAGCCAGCTCCGCGGCTCCACCCAGGGCAAGATCC
  TCTGCTTCTATGGCCCCCCTGGCGTGGGTAAGACCAGCATTGCTCGCTCCATCGCCCGCG
  CCCTGAACCGAGAGTACTTCCGCTTCAGCGTCGGGGGCATGACTGACGTGGCTGAGATCA
  AGGGCCACAGGCGGACCTACGTGGGCGCCATGCCCGGGAAGATCATCCAGTGTTTGAAGA
  AGACCAAGACGGAGAACCCCCTGATCCTCATCGACGAGGTGGACAAGATCGGCCGAGGCT
  ACCAGGGGGACCCGTCGTCGGCACTGCTGGAGCTGCTGGACCCAGAGCAGAATGCCAACT
  TCCTGGACCACTACCTGGACGTGCCCGTGGACTTGTCCAAGGTGCTGTTCATCTGCACGG
  CCAACGTCACGGACACCATCCCCGAGCCGCTGCGAGACCGTATGGAGATGATCAACGTGT
  CGGGCTACGTGGCCCAGGAGAAGCTGGCCATTGCGGAGCGCTACCTGGTGCCCCAGGCTC
  GCGCCCTGTGTGGCTTGGATGAGAGCAAGGCCAAGCTGTCATCGGACGTGCTGACGCTGC
  TCATCAAGCAGTACTGCCGCGAGAGCGGTGTCCGCAACCTGCAGAAGCAAGTGGAGAAGG
  TGTTACGGAAATCGGCCTACAAGATTGTCAGCGGCGAGGCCGAGTCCGTGGAGGTGACGC
  CCGAGAACCTGCAGGACTTCGTGGGGAAGCCCGTGTTCACCGTGGAGCGCATGTATGACG
  TGACACCGCCCGGCGTGGTCATGGGGCTGGCCTGGACCGCAATGGGAGGCTCCACGCTGT
  TTGTGGAGACATCCCTGAGACGGCCACAGGACAAGGATGCCAAGGGTGACAAGGATGGCA
  GCCTGGAGGTGACAGGCCAGCTGGGGGAGGTGATGAAGGAGAGCGCCCGCATAGCCTACA
  CCTTCGCCAGAGCCTTCCTCATGCAGCACGCCCCCGCCAATGACTACCTGGTGACCTCAC
  ACATCCACCTGCATGTGCCCGAGGGCGCCACCCCCAAGGACGGCCCAAGCGCAGGCTGCA
  CCATCGTCACGGCCCTGCTGTCCCTGGCCATGGGCAGGCCTGTCCGGCAGAATCTGGCCA
  TGACTGGCGAAGTCTCCCTCACGGGCAAGATCCTGCCTGTTGGTGGCATCAAGGAGAAGA
  CCATTGCGGCCAAGCGCGCAGGGGTGACGTGCATCGTCCTGCCAGCCGAGAACAAGAAGG
  ACTTCTACGACCTGGCAGCCTTCATCACCGAGGGCCTGGAGGTGCACTTCGTGGAACACT
  ACCGGGAGATCTTCGACATCGCCTTCCCGGACGAGCAGGCAGAGGCGCTGGCCGTGGAAC
  GGTGACGGCCACCCCGGGACTGCAGGCGGCGGATGTCAGGCCCTGTCTGGGCCAGAACTG
  AGCGCTGTGGGGAGCGCGCCCGGACCTGGCAGTGGAGCCACCGAGCGAGCAGCTCGGTCC
  AGTGACCCAGATCCCAGGGACCTCAGTCGGCTTAATCAGAGTGTGGCATAGAAGCTATTT
  AATGATTAAAGTCATTTGCAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004793.2 unedited
  GCCAATTGTAATACGACTCCTATAGGGCGGCCGGGAATCGGCACGAGGGGGCTATGGCGG
  CGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGA
  TGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCC
  AGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGG
  GCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCG
  AGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGGGGGGCAGCGCGGGCG
  CCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGC
  ACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCG
  AGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTT
  ATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGG
  ATGAAAATCTACCAACACGGAGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGA
  CAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCACCAGACAGCTGGAAGT
  TGAGCCCGAGGAGCCGGAAGGCGGAGAACAAGCACAAGCCCCGCAGAACGTTCAACAGCG
  GGCATAGAACGGAGGCGGAAGACGAAGCTGGAAGCCGCCAGGCACCCGGCGGAGCTTGCC
  GATTGGAGCCCACCCTGAACCTCCCGGCCTTGAGTTTGCTTATTGTGGTGAGTTCAAGAC
  AGCGTTTGTTCGCAGAGGTACTTTCCAGGTCACGGAAGGATGTGTAAAGCCTTGAACTGC
  AGAATCTTGGAGAACAATCGCCGAAACATCTATGCCTTTGAACCTCTCTTTTTACGCGTA
• Restriction Sites: Please inquire
• ACCN: NM_004793
• ORF Size: 2880 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004793.2, NP_004784.2
• RefSeq Size: 3111
• RefSeq ORF: 2880
• Locus ID: 9361
• Domains: LON, AAA, AAA
• Protein Families: Druggable Genome, Protease
• Gene Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
  Transcript Variant: This variant (1) encodes the longest isoform (1).