LATS1 (NM_004690) Human Untagged Clone

CAT#: SC117200

LATS1 (untagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1)


  "NM_004690" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol LATS1
Synonyms WARTS; wts
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_004690 edited
ATGAAGAGGAGTGAAAAGCCAGAAGGATATAGACAAATGAGGCCTAAGACCTTTCCTGCC
AGTAACTATACTGTCAGTAGCCGGCAAATGTTACAAGAAATTCGGGAATCCCTTAGGAAT
TTATCTAAACCATCTGATGCTGCTAAGGCTGAGCATAACATGAGTAAAATGTCAACCGAA
GATCCTCGACAAGTCAGAAATCCACCCAAATTTGGGACGCATCATAAAGCCTTGCAGGAA
ATTCGAAACTCTCTGCTTCCATTTGCAAATGAAACAAATTCTTCTCGGAGTACTTCAGAA
GTTAATCCACAAATGCTTCAAGACTTGCAAGCTGCTGGATTTGATGAGGATATGGTTATA
CAAGCTCTTCAGAAAACTAACAACAGAAGTATAGAAGCAGCAATTGAATTCATTAGTAAA
ATGAGTTACCAAGATCCTCGACGAGAGCAGATGGCTGCAGCAGCTGCCAGACCTATTAAT
GCCAGCATGAAACCAGGGAATGTGCAGCAATCAGTTAACCGCAAACAGAGCTGGAAAGGT
TCTAAAGAATCCTTAGTTCCTCAGAGGCATGGCCCGCCACTAGGAGAAAGTGTGGCCTAT
CATTCTGAGAGTCCCAACTCACAGACAGATGTAGGAAGACCTTTGTCTGGATCTGGTATA
TCAGCATTTGTTCAAGCTCACCCTAGCAACGGACAGAGAGTGAACCCCCCACCACCACCT
CAAGTAAGGAGTGTTACTCCTCCACCACCTCCAAGAGGCCAGACTCCCCCTCCAAGAGGT
ACAACTCCACCTCCCCCTTCATGGGAACCAAACTCTCAAACAAAGCGCTATTCTGGAAAC
ATGGAATACGTAATCTCCCGAATCTCTCCTGTCCCACCTGGGGCATGGCAAGAGGGCTAT
CCTCCACCACCTCTCAACACTTCCCCCATGAATCCTCCTAATCAAGGACAGAGAGGCATT
AGTTCTGTTCCTGTTGGCAGACAACCAATCATCATGCAGAGTTCTAGCAAATTTAACTTT
CCATCAGGGAGACCTGGAATGCAGAATGGTACTGGACAAACTGATTTCATGATACACCAA
AATGTTGTCCCTGCTGGCACTGTGAATCGGCAGCCACCACCTCCATATCCTCTGACAGCA
GCTAATGGACAAAGCCCTTCTGCTTTACAAACAGGGGGATCTGCTGCTCCTTCGTCATAT
ACAAATGGAAGTATTCCTCAGTCTATGATGGTGCCAAACAGAAATAGTCATAACATGGAA
CTATATAACATTAGTGTACCTGGACTGCAAACAAATTGGCCTCAGTCATCTTCTGCTCCA
GCCCAGTCATCCCCGAGCAGTGGGCATGAAATCCCTACATGGCAACCTAACATACCAGTG
AGGTCAAATTCTTTTAATAACCCATTAGGAAATAGAGCAAGTCACTCTGCTAATTCTCAG
CCTTCCGCTACAACAGTCACTGCAATTACACCAGCTCCTATTCAACAGCCTGTGAAAAGT
ATGCGTGTATTAAAACCAGAGCTACAGACTGCTTTAGCACCTACACACCCTTCTTGGATA
CCACAGCCAATTCAAACTGTTCAACCCAGTCCTTTTCCTGAGGGAACCGCTTCAAATGTG
ACTGTGATGCCACCTGTTGCTGAAGCTCCAAACTATCAAGGACCACCACCACCCTACCCA
AAACATCTGCTGCACCAAAACCCATCTGTTCCTCCATACGAGTCAATCAGTAAGCCTAGC
AAAGAGGATCAGCCAAGCTTGCCCAAGGAAGATGAGAGTGAAAAGAGTTATGAAAATGTT
GATAGTGGGGATAAAGAAAAGAAACAGATTACAACTTCACCTATTACTGTTAGGAAAAAC
AAGAAAGATGAAGAGCGAAGGGAATCTCGTATTCAAAGTTATTCTCCTCAAGCATTTAAA
TTCTTTATGGAGCAACATGTAGAAAATGTACTCAAATCTCATCAGCAGCGTCTACATCGT
AAAAAACAATTAGAGAATGAAATGATGCGGCTGATTTAAACTTTTATGGTGTTGGAAGCT
TTGCTGACTTCTGTAGTCTCCATTACTGTGTAGGTTGGATTATCTCAAGATGCCCAGGAT
CAAATGAGAAAGATGCTTTGCCAAAAAGAATCTAATTACATCCGTCTTAAAAGGGCTAAA
ATGGACAAGTCTATGTTTGTGAAGATAAAGACACTAGGAATAGGAGCATTTGGTGAAGTC
TGTCTAGCAAGAAAAGTAGATACTAAGGCTTTGTATGCAACAAAAACTCTTCGAAAGAAA
GATGTTCTTCTTCGAAATCAAGTCGCTCATGTTAAGGCTGAGAGAGATATCCTGGCTGAA
GCTGACAATGAATGGGTAGTTCGTCTATATTATTCATTCCAAGATAAGGACAATTTATAC
TTTGTAATGGACTACATTCCTGGGGGTGATATGATGAGCCTATTAATTAGAATGGGCATC
TTTCCAGAAAGTCTGGCACGATTCTACATAGCAGAACTTACCTGTGCAGTTGAAAGTGTT
CATAAAATGGGTTTTATTCATAGAGATATTAAACCTGATAATATTTTGATTGATCGTGAT
GGTCATATTAAATTGACTGACTTTGGCCTCTGCACTGGCTTCAGATGGACACACGATTCT
AAGTACTATCAGAGTGGTGACCATCCACGGCAAGATAGCATGGATTTCAGTAATGAATGG
GGGGATCCCTCAAGCTGTCGATGTGGAGACAGACTGAAGCCATTAGAGCGGAGAGCTGCA
CGCCAGCACCAGCGATGTCTAGCACATTCTTTGGTTGGGACTCCCAATTATATTGCACCT
GAAGTGTTGCTACGAACAGGATACACACAGTTGTGTGATTGGTGGAGTGTTGGTGTTATT
CTTTTTGAAATGTTGGTGGGACAACCTCCTTTCTTGGCACAAACACCATTAGAAACACAA
ATGAAGGTTATCAACTGGCAAACATCTCTTCACATTCCACCACAAGCTAAACTCAGTCCT
GAAGCTTCTGATCTTATTATTAAACTTTGCCGAGGACCCGAAGATCGCTTAGGCAAGAAT
GGTGCTGATGAAATAAAAGCTCATCCATTTTTTAAAACAATTGATTTCTCCAGTGACCTG
AGACAGCAGTCTGCTTCATACATTCCTAAAATCACACACCCAACAGATACATCAAATTTT
GATCCTGTTGATCCTGATAAATTATGGAGTGATGATAACGAGGAAGAAAATGTAAATGAC
ACTCTCAATGGATGGTATAAAAATGGAAAGCATCCTGAACATGCATTCTATGAATTTACC
TTCCGAAGGTTTTTTGATGACAATGGCTACCCATATAATTATCCGAAGCCTATTGAATAT
GAATACATTAATTCACAAGGCTCAGAGCAGCAGTCGGATGAAGATGATCAAAACACAGGC
TCAGAGATTAAAAATCGCGATCTAGTATATGTTTAACACACTAGTAAATAAATGTAATGA
GGATTTGTAAAAGGGCCTGAAATGCGAGGTGTTTTGAGGTTCTGAGAGTAAAATTATGCA
AATATGACAGAGCTATATATGTGTGCTCTGTGTACAATATTTTATTTTCCTAAATTATGG
GAAATCCTTTTAAAATGTTAATTTATTCCAGCCGTTTAAATCAGTATTTAGAAAAAAATT
GTTATAAGGAAAGTAAATTATGAACTGAATATTATAGTCAGTTCTTGGTACTTAAAGTAC
TTAAAATAAGTAGTGCTTTGTTTAAAAGGAGAAACCTGGTATCTATTTGTATATATGCTA
AATAATTTTAAAATACAAGAGTTTTTGAAATTTTTTTGAAAGACAGTTTTAGTTTTATCT
TGCTTTAACCAAATATGAAACATACCCCCTATTTTACAGAGCTCTTTTTTCCCCTCATAA
CCTCGTTTTTGGTAGAAAATAAGCTAGAGAAATTAAGCCATCGTGTTGGTGAGTGTTCCT
AGGCTAATGATAATCTGTATAATTCACATCCTGAAACTAAGGAATACAGGGTTGAAAAAA
TATTAATATGTTTGTCAGAAGGAAAAATAATGCATTTATCTTCCCCCCCCACCCCCCGCC
CCATGGAATATTTAATCTATTTAATCTTCTTGCATTTATTTCTCAAGAATTACTGGCTTT
AAAAGAAGCCAAAGCACTACTAGCTTTTTTTCCATATTGGTATTTTTGATGCTGCTTCCA
ATTTTAAAAGGGAACAAAGCTGCCATAAATCGAAATGTTCAATACTAAAAGCTAAAATAT
TTCTCACCATCCTAAGCAGATAATTATTTTAATTTTCATATACTTTTCCTGTATAGTAAC
TATTTTGATTATATCATCAATGTTACCTGTTTCCTCTTTCAGAACAGTGCTGCATATACA
GATTGTTATTGGCAAAGGAAAATCTGGCTATCTGGCAATATTTTACCTAAGCGCAGATTA
ATTGGTGAAAAAATTAACTCTTAAGATGGCCATTAATAATTAGGAAAGTTTACAGAGTGG
TCTTAGTAGAAAATTCAAGTCCTCCTAATTTATTTAAGGTTCAATAATGCGTTCAACATG
CCTGTTATGTATAACGCTTAGGTTCTAAGGAAGATTAAGGTTTCATACCAAAATACATGT
AGCTTATCTTTTAGGAAGGGGAAAAAGGCTCCATTTTGACCATAGTAAAATTTGTGTTGT
GTTTTATTTCCTTTTCTTAAGCTCCACTGATAAGGGATTGTTTTTATCAAAAGTTACTAT
TTGTAGATTGGAGGCATAATTTTAGTGATTTTCATACTTTTAGCTTTCTTCGCATAAAAG
CTAATTGAAACCGTATATGTAGTAAAATTAAAGGCAGAGCTGTTGCAGTTGAATTGGAGA
GTCAGGGCAAAGAACACTTATTAGCCCACACTTCCCACCTTTCTACAGGTGGTCCTTTCA
GAGCTCAGCCTGGAAAACCCACTACTGTGTTATCGTGCGTCTTTTGGGGTTAGTGGKTCT
TTTGAGAATCTGAAGGAAGCTGTGGACTCTTCCTAGAAAAAAAAACCACACATACACATA
CAATGTTGCATGCAGTTTCAAGGGATTTTGGACATATTGAAACCTATCACAGGCTGTAGG
TTATGGACCTCTGTGCCATGAGAAAATTGATACATTAAACTAAGAACTTTGTTTTTAACT
TACCAATCACTACTCAGCACATCTTATATAAGCTGATAATTTGTGATGGAAAAGGTCTGT
AGCATGTGATATAAGGTGACCTTATGAATGCCTCTCTTGCTGGTACATTAAGTTGTTTTA
ATATATCATTTGGAGGGGACTGAAATGTTAGGCTCATTACAAGCTTGATACAGAAATATT
TCTGAAGGATTTCTAATCAGAATTGTAAAACAATGTGCTATCATGAAATCGCAGTCTTCA
CCTCATGGTTCATGGAACATTTGGTTAGTCCCATAAAATCCTATGCAAAACAAAGTAGTT
CAAGAATTTTTAGGTGGGTAGTCACATTTATAAGGTATTCCTCTTACTCTTTGGGCTTTT
TCAGTCTGATTTATTTAAATTTTCATTTAGTTGTTTTACTTTTGGACTAAGGTGCAATAC
AGTAGAAGATAACTTCGTTACATTTATGTTGTAGGAAAACTAAGGTGCTGTCTCCTCCCC
CTTCCCTTCCCACAAAATCTGTATTCCCCCTATTGCTGAAATGTAACAGACACTACAAAT
TTTGTATTCTTTTTTTGTTTTTTGTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGG
AGGGCAGTGGCGCTTCACAGCTCACTGCATCCTCAACCTTGGGGGCTCACGCAGTCCTCC
CGCCTCAGCCTCCCAAGTAGCTGGGCATGCGCCACCAAGCCCAGCTAATGTTTGTATCTT
TAGTAGAGATGGGGTTTCGCCATGTTGCCCAGGTTGGTGTGGAATTCCTGGGCTCCAGTT
ATATGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGACCCACCGCGCCTGGC
GCAAATATGTATTCTTTTAAAATTTCCTCTGATACTATAAGCTTTTTGCATTTATCTGAA
GCAGTATACATGCCTTTGGTATCAGCAATTTTAACAGTTTGGATATACTTATCAGCTATC
TTATTCCAAAACTACATCTACTTCTTCCAGTATAGAATCTGGTGCTTCCTGACCAAAAAG
ATGAGAAAAACAATGTTAAAAATATAGATGCTTTCCATTGAAATGGAGTGAAAACATTGG
TTCTATATGTTTTCTTTTAAAATAATTTTCTTATTAAAAACTTGCTGTCTTTATTATACT
TACCCTTTTTATGCATATCAATAGTATTTATAAGATGTGTTCTATAATTATGTAATTGTA
GATACTGTTATGCATTGTCCAGTGACATCATAAGGCAGGCCCTACTGCTGTATCTTTTCT
ACTTTCTTATTTGTAATAGAAACTATAGAATGTATGACTAAAAAGTCACTTTGAGATTGA
CTTTTTTAAAAAGTTATTACCTTCTGCTGTTGCAAAGTGCAAAACTGTGAGTGGAATTGT
TTTATTCTGACTTAATGTGTTAGAAATTAGAGAATACAGTGGGAGGATTTTTAGACATTG
CTGCTGCTGTTACCCAAGGTATTTTAGATAAAAAATTTTAAATAAACATCCCTTTGGTAT
TTAAAGTGGAACATTTAGCCTGTTCATTTTAATCTAAAGCAAAAAGTAATTTGGGTCAAA
ATATTGGTATATTTGTAAAGCGCCTTAATATATCCCTTTGTGGAAGGCACTACACAGTTT
ACTTTTATATTGTATTGTGTATATAAGTATTTTGTATTAAAATTGAATCAGTGGCAACAT
TAAAGTTTTATAAAATCATGCTTTGTTAGAAAAAGAATTACAGCTTTGCAATATAACTAA
TTGTTTTGCATAATTCTGAATGTAATAGATATGAATAATCAGCCTGTGTTTTTAATGAAC
TTACTTTGTATTTTCCCAATCATTTTCTCTAGTGTAATGTTTGCTGGGATAATAAAAAAA
ATTCAAATCTTTCAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATA
GCTGTTTCCTGAACAGATCCCGGGTGGCATCCCTGTGACCCCTCCCCAGTGCCTCTCCGG
CCCGAG
>OriGene 5' read for NM_004690 unedited
GTCAGATTTTGTAATACGACTTACTATAGGGCGGCCGCGAAATTCGCACCAGGCGGCGGC
GGCGGTGGCCTGGTGTTAAGGGGAGAGCCAGGTCCTTACGACCCCTGGGACGGGCCGCGC
TGGCCCGCGGCAGCCCCCCCGTTCGTCTCCCCGCTCTGCCCCACCAGGGATACTTGGGGT
TGCTGGGACGGACTCTGGCCGCCTCAGCGTCCGCCCTCAGGCCCGTGGCCGCTGTCCAGG
AGCTCTGCTCTCCCCTCCAGAGTTAATTATTTATATTGTAAAGAATTTTAACAGTCCTGG
GGACTTCCTTGAAGCATCATTTTCACTTTTGCTCAGAAGAAAGCTCTGGATCTATCAAAT
AAAGAAGTCCTTCGTGTGGGCTACATATATAGATGTTTTCATGAAGAGGAGTGAAAAGCC
AGAAGGATATAGACAAATGAGGCCTAAGACCTTTCCTGCCAGTAACTATACTGTCAGTAG
CCGGCAAATGTTACAAGAAATTCGGGAATCCCTTAGGAATTTATCTAAACCATCTGATGC
TGCTAAGGCTGAGCATAACATGAGTAAAATGTCAACCGAAGATCCTCGACAAGTCAGAAA
TCCACCCAAATTTGGGACGCATCATAAAGCCTTGCAGGAAATTCGAAACTCTCTGCTTCC
ATTTGCAAATGAAACAAATTCTTCTCGGAGTACTTCAGAAGTTAATCCACAAATGCTTCA
AGACTTGCAAGCTGCTGGATTTGATGAGGATATGGTTATACAAGCTCTTCAGAAACTAAC
ACAGAATATAGAAGCAGCAATTGAATCATTAGTAAATGAGTACCAAGATCCTCGACGAGA
GCAGATGCTGCAGCAGCTGCCAGACCTATTATGCCAGCATGAAACCGGGGATGTGCAGNC
ATCAGTTAACCGCANACAGAGCTGGAAAGGGTCTAAAGATNCCTATTCCTCAGAGCATGG
NCCGCCN
Restriction Sites NotI-NotI     
ACCN NM_004690
ORF Size 3393 bp
Insert Size 4700
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_004690.2, NP_004681.1
RefSeq Size 4756
RefSeq ORF 3393
Locus ID 9113
Domains UBA, pkinase
Protein Families Druggable Genome, Protein Kinase
Gene Summary The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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