Tyrosyl tRNA synthetase (YARS) (NM_003680) Human Untagged Clone

CAT#: SC117859

YARS (untagged)-Human tyrosyl-tRNA synthetase (YARS)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: YARS
• Synonyms: CMTDIC; TYRRS; YRS; YTS
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117859 sequence for NM_003680 edited (data generated by NextGen Sequencing)
  ATGGGGGACGCTCCCAGCCCTGAAGAGAAACTGCACCTTATCACCCGGAACCTGCAGGAG
  GTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTAAAATTTACTGG
  GGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGTCAAAGATTGCA
  GACTTCTTAAAGGCAGGGTGTGAGGTAACAATTCTGTTTGCGGACCTCCACGCATACCTG
  GATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACTATGAGAATGTG
  ATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGTTCATCAAAGGC
  ACTGATTACCAGCTCAGCAAAGAGTACACACTAGATGTGTACAGACTCTCCTCCGTGGTC
  ACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGGAGCACCCTTTG
  CTGAGTGGCCTCTTATACCCCGGACTGCAGGCTTTGGATGAAGAGTATTTAAAAGTAGAT
  GCCCAATTTGGAGGCATTGATCAGAGAAAGATTTTCACCTTTGCAGAGAAGTACCTCCCT
  GCACTTGGCTATTCAAAACGGGTCCATCTGATGAATCCTATGGTTCCAGGATTAACAGGC
  AGCAAAATGAGCTCTTCAGAAGAGGAGTCCAAGATTGATCTCCTTGATCGGAAGGAGGAT
  GTGAAGAAAAAACTGAAGAAGGCCTTCTGTGAGCCAGGAAATGTGGAGAACAATGGGGTT
  CTGTCCTTCATCAAGCATGTCCTTTTTCCCCTTAAGTCCGAGTTTGTGATCCTACGAGAT
  GAGAAATGGGGTGGAAACAAAACCTACACAGCTTACGTGGACCTGGAAAAGGACTTTGCT
  GCTGAGGTTGTACATCCTGGAGACCTGAAGAATTCTGTTGAAGTCGCACTGAACAAGTTG
  CTGGATCCAATCCGGGAAAAGTTTAATACCCCTGCCCTGAAAAAACTGGCCAGCGCTGCC
  TACCCAGATCCCTCAAAGCAGAAGCCAATGGCCAAAGGCCCTGCCAAGAATTCAGAACCA
  GAGGAGGTCATCCCATCCCGGCTGGATATCCGTGTGGGGAAAATCATCACTGTGGAGAAG
  CACCCAGATGCAGACAGCCTGTATGTAGAGAAGATTGACGTGGGGGAAGCTGAACCACGG
  ACTGTGGTGAGCGGCCTCGTACAGTTCGTGCCCAAGGAGGAACTGCAGGACAGGCTGGTA
  GTGGTGCTGTGCAACCTGAAACCCCAGAAGATGAGAGGAGTCGAGTCCCAAGGCATGCTT
  CTGTGTGCTTCTATAGAAGGGATAAACCGCCAGGTTGAACCTCTGGACCCTCCGGCAGGC
  TCTGCTCCTGGTGAGCACGTGTTTGTGAAGGGCTATGAAAAGGGCCAACCAGATGAGGAG
  CTCAAGCCCAAGAAGAAAGTCTTCGAGAAGTTGCAGGCTGACTTCAAAATTTCTGAGGAG
  TGCATCGCACAGTGGAAGCAAACCAACTTCATGACCAAGCTGGGCTCCATTTCCTGTAAA
  TCGCTGAAAGGGGGGAACATTAGCTAG
  
  Clone variation with respect to NM_003680.3
  1218 g=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003680 unedited
  GGCGCCCCGTTCCACGCTAGGGCGGTAGGCAAGTCCGGTGGGAGGTCTATATAAGCAGAG
  CTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTC
  GGCACGAGCGACGGTGACCCAGGAAGGGGCTCTGGTGCCGGGCTGAGCGGGGGAAGCAGG
  GGTAGCGGAGCCATGGGGGACGCTCCTTTTTTGTTGAGAAACTGCACCTTATCACCCGGA
  ACCTGCAGGAGGTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTA
  AAATTTACTGGGGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGT
  CAAAGATTGCAGACTTCTTAAAGGCAGGGTGTGAGGTAACAATTCTGTTTGCGGACCTCC
  ACGCATACCTGGATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACT
  ATGAGAATGTGATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGT
  TCATCAAAGGCACTGATTACCAGCTCAGCAAAGAGTACACACTAGATGTGTACAGACTCT
  CCTCCGTGGTCACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGG
  AGCACCCTTTGCTGAGTGGCCTCTTATACCCCGGACTGCAAGCTTTGGATGAAGAGTATT
  TAAAAGTAGATGCCCAATTTGGNANGCATTGATCAGAGAAAGATTTTCACCCTTGCAGAG
  AAGTACCTCCCTGCACTTGGCTATTCAAACGGGTCCATCTGATGAATCCTATGGTTCCGG
  ATTAAACAGCAGCANAATGAGCTCTTCAGAAGAGGAGTCAAGTATGATCTCCTTGATCGG
  AAAGGAGATGTGAAGAAAAAACTGTAGAAGGCCTTCTGGGAGCCAGGAATGTGGANAACA
  TGGGGTTCTGTCTTCATCAGCATGTCTTTTTTCCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003680
• ORF Size: 1587 bp
• Insert Size: 2600
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003680.2, NP_003671.1
• RefSeq Size: 3137
• RefSeq ORF: 1587
• Locus ID: 8565
• Domains: tRNA-synt_1b, tRNA_bind
• Protein Families: Druggable Genome
• Protein Pathways: Aminoacyl-tRNA biosynthesis
• Gene Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]