Zyxin (ZYX) (NM_003461) Human Untagged Clone

CAT#: SC117947

ZYX (untagged)-Human zyxin (ZYX), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ZYX
• Synonyms: ESP-2; HED-2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117947 sequence for NM_003461 edited (data generated by NextGen Sequencing)
  ATGGCGGCCCCCCGCCCGTCTCCCGCGATCTCCGTTTCGGTCTCGGCTCCGGCTTTTTAC
  GCCCCGCAGAAGAAGTTCGGCCCTGTGGTGGCCCCAAAGCCCAAAGTGAATCCCTTCCGG
  CCCGGGGACAGCGAGCCTCCCCCGGCACCCGGGGCCCAGCGCGCACAGATGGGCCGGGTG
  GGCGAGATTCCCCCGCCGCCCCCGGAAGACTTTCCCCTGCCTCCACCTCCCCTTGCTGGG
  GATGGCGACGATGCAGAGGGTGCTCTGGGAGGTGCCTTCCCGCCGCCCCCTCCCCCGATC
  GAGGAATCATTTCCCCCTGCGCCTCTGGAGGAGGAGATCTTCCCTTCCCCGCCGCCTCCT
  CCGGAGGAGGAGGGAGGGCCTGAGGCCCCCATACCGCCCCCACCACAGCCCAGGGAGAAG
  GTGAGCAGTATTGATTTGGAGATCGACTCTCTGTCCTCACTGCTGGATGACATGACCAAG
  AATGATCCTTTCAAAGCCCGGGTGTCATCTGGATATGTGCCCCCACCAGTGGCCACTCCA
  TTCAGTTCCAAGTCCAGTACCAAGCCTGCAGCCGGGGGCACAGCACCCCTGCCTCCTTGG
  AAGTCCCCTTCCAGCTCCCAGCCTCTGCCCCAGGTTCCGGCTCCGGCTCAGAGCCAGACA
  CAGTTCCATGTTCAGCCCCAGCCCCAGCCCAAGCCTCAGGTCCAACTCCATGTCCAGTCC
  CAGACCCAGCCTGTGTCTTTGGCTAACACCCAGCCCCGAGGGCCCCCAGCCTCATCTCCG
  GCTCCAGCCCCTAAGTTTTCTCCAGTGACTCCTAAGTTTACTCCTGTGGCTTCCAAGTTC
  AGTCCTGGAGCCCCAGGTGGATCTGGGTCACAACCAAATCAAAAATTGGGGCACCCCGAA
  GCTCTTTCTGCTGGCACAGGCTCCCCTCAACCTCCCAGCTTCACCTATGCCCAGCAGAGG
  GAGAAGCCCCGAGTGCAGGAGAAGCAGCACCCCGTGCCCCCACCGGCTCAGAACCAAAAC
  CAGGTGCGCTCCCCTGGGGCCCCAGGGCCCCTGACTCTGAAGGAGGTGGAGGAGCTGGAG
  CAGCTGACCCAGCAGCTAATGCAGGACATGGAGCATCCTCAGAGGCAGAATGTGGCTGTC
  AACGAACTCTGCGGCCGATGCCATCAACCCCTGGCCCGGGCGCAGCCAGCCGTCCGCGCT
  CTAGGGCAGCTGTTCCACATCGCCTGCTTCACCTGCCACCAGTGTGCGCAGCAGCTCCAG
  GGCCAGCAGTTCTACAGTCTGGAGGGGGCGCCGTACTGCGAGGGCTGTTACACTGACACC
  CTGGAGAAGTGTAACACCTGCGGGGAGCCCATCACTGACCGCATGCTGAGGGCCACGGGC
  AAGGCCTATCACCCGCACTGCTTCACCTGTGTGGTCTGCGCCCGCCCCCTGGAGGGCACC
  TCCTTCATCGTGGACCAGGCCAACCGGCCCCACTGTGTCCCCGACTACCACAAGCAGTAC
  GCCCCGAGGTGCTCCGTCTGCTCTGAGCCCATCATGCCTGAGCCTGGCCGAGATGAGACT
  GTGCGAGTGGTCGCCCTGGACAAGAACTTCCACATGAAGTGTTACAAGTGTGAGGACTGC
  GGGAAGCCCCTGTCGATTGAGGCAGATGACAATGGCTGCTTCCCCCTGGACGGTCACGTG
  CTCTGTCGGAAGTGCCACACTGCTAGAGCCCAGACCTGA
  
  Clone variation with respect to NM_003461.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003461 unedited
  TTTGTAATACGACTCACTATAGGGCGGCCGCGCCGGCGCCGAGGCGGCCACCCGAGACGC
  GGCGCGCACGCTCCGGCCTGCGCAGCCCGGCCCGGCCATGGCGGCCCCCCGCCCGTCTCC
  CGCGATCTCCGTTTCGGTCTCGGCTCCGGCTTTTTACGCCCCGCAGAAGAAGTTCGGCCC
  TGTGGTGGCCCCAAAGCCCAAAGTGAATCCCTTCCGGCCCGGGGACAGCGAGCCTCCCCC
  GGCACCCGGGGCCCAGCGCGCACAGATGGGCCGGGTGGGCGAGATTCCCCCGCCGCCCCC
  GGAAGACTTTCCCCTGCCTCCACCTCCCCTTGCTGGGGATGGCGACGATGCAGAGGGTGC
  TCTGGGAGGTGCCTTCCCGCCGCCCCCTCCCCCGATCGAGGAATCATTTCCCCCTGCGCC
  TCTGGAGGAGGAGATCTTCCCTTCCCCGCCGCCTCCTCCGGAGGAGGAGGGAGGGCCTGA
  GGCCCCCATACCGCCCCCACCACAGGTACGGAGGCCTGGGAGGGGCGGCTGCACTGGACA
  CCCCCAAGGAGAGGAGAAGAGGGCCCTTTCTTCTTACCTCCCCTGCACCTCTGCCTTGGG
  GGTGGGGGGATAGAGGCATGGAATAGGTGCTCTGACCTCTGACCCTCTAGCCCAGGGAGA
  AGGTGAGCAGTATTGATTTGGAGATCGACTCTCTGTCCTCACTGCTGGATGACATGACCA
  AGAATGATCCTTTTCANAGCCCGGNTGTCATTCTGGATATGTGCCCCCACCAGTGGCCAC
  TTCATTCAGTTTCCAGTTCAGTACCAAGCCTGCAGCCCGGGGCACAGCACCCCTGGCTCC
  TTGGAAGTCCCCTTNCAGCTCCCAGCTCTGCCCCAGGTTCCGCTCCGNCTTAAACCCAAA
  ACATTTCTTGTTCAGCCCCACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003461 unedited
  GTACGCGGCCGCAATTTANGATCGAGTTTTTTTTTTTTTTTTTTGGAAAACAAGGTTTTT
  TTTTATTTGTAGCTATAGCTACAACTTGGCAGCATGGGGGAGGGTGGGAATGTCCTGGAG
  GGTCTCCCAGCCCTCCGCAAGCAGAGTACAAAGGCTGCTTGGGGGGCCGGCCGAGGGCGC
  GGGTGCAGCAGTGAAAGCAGCAGCACTAAACCTGGTGCCCCCCTCAGGTGGGGTGTCTGG
  AAGACGGTGGGCAATCCCTGCAGGATGGGCGAGGACCAGACCCCAGGGCGGGGATCCTGC
  ATCCCTAGACCATGTTGGGTCCTGGGTCAGGGCACCTGGGATGCTAGGGAGGGGTTGGAA
  ATGGGAGGGGCTAGACATCAAAACAATAACTGAGGTGGGGGCAGGTGGTCTCAGTGTGGG
  TGGTCCACAATGGGGCATGGACTGCGGTCTGAAGAGGGCCTGTCCTCACTCAGGTCTGGG
  CTCTAGCAGTGTGGCACTTCCGACAGAGCACGTGACCGTCCAGGGGGAAGCAGCCATTGT
  CATCTGCCTCAATCGACAGGGGCTTCCCGCAGTCCTCACACTTGTAACACTTCATGTGGA
  AGTTCTTGTCCAGGGCGACCACTCGCACAGTCTCATCTCGGCCAGGCTCAGGCATGATGG
  GCTCAGAGCAGACGGAGCACCTCGGCGCGTACTGCTTGTGGTAGTCGGGGACACAGTGGG
  GCCCGGTTGGCCTTGTCCACGATGAAAGAAGTGCCCTCAGGGGGCGGGCGCACACACACA
  GTGAAGCAGTGCCGGTGAAAGGCTTGCCCGGGCCCTTAACATGCGCCAATGATGGCTCCC
  CCCAGGGTTACACCTCTCCGGGNGATAGGGAACAAGCCCTCGCAGAAGGCCGCCACTCCA
  AAATGACAACTGGGTCCCTGGGN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003461
• ORF Size: 1719 bp
• Insert Size: 2390
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003461.4, NP_003452.1
• RefSeq Size: 2325
• RefSeq ORF: 1719
• Locus ID: 7791
• Domains: LIM
• Protein Pathways: Focal adhesion
• Gene Summary: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.