RANTES (CCL5) (NM_002985) Human Untagged Clone

CAT#: SC118321

CCL5 (untagged)-Human chemokine (C-C motif) ligand 5 (CCL5)


  "NM_002985" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CCL5
Synonyms D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC118321 sequence for NM_002985 edited (data generated by NextGen Sequencing)
ATGAAGGTCTCCGCGGCAGCCCTCGCTGTCATCCTCATTGCTACTGCCCTCTGCGCTCCT
GCATCTGCCTCCCCATATTCCTCGGACACCACACCCTGCTGCTTTGCCTACATTGCCCGC
CCACTGCCCCGTGCCCACATCAAGGAGTATTTCTACACCAGTGGCAAGTGCTCCAACCCA
GCAGTCGTCTTTGTCACCCGAAAGAACCGCCAAGTGTGTGCCAACCCAGAGAAGAAATGG
GTTCGGGAGTACATCAACTCTTTGGAGATGAGCTAG

Clone variation with respect to NM_002985.2
>OriGene 5' read for NM_002985 unedited
CCGCAGAGGGAAAGCACGTGGACCTCGCACGCCTCTTCCCCAGTACCAGAAGGTCTCCGC
GGCAGCCCTCGCTGTCATCCTCATTGCTACTTGCCCTCTGCGCTCCTGCATCTGCCTCCC
CTTATTCCTCGGACACCACACCCTGCTGCTTTGCCTACATTGCCCGCCCACTGCCCCGTG
CCCACATCAAGGAGTATTTCTACACCAGTGGCAAGTGCTCCAACCCAGCAGTCGTCTTTG
TCACCCGAAAGAACCGCCAAGTGTGTGCCAACCCAGAAAAGAAATGGGTTCGGGAGTACA
TCAACTCTTTGGAGATGAGCTAGGATGGAGAGTCCTTGAACCTGAACTTACACAAATTTG
CCTGTTTCTGCTTGCTCTTGTCCTAGCTTGGGAGGCTTCCCCTCACTATCCTACCCCACC
CGCTCCTTGAAGGGCCCAGATTCTACCACACAGCAGCAGTTACAAAAACCTTCCCCAGGC
TGGAATGGTGCTCTACGCCCTGTGTAATCCAACACTTTTGGAAGCCCAGGTGGGTTGGAT
CACCTGANGTCAGGAGTTCGAGACCAGCCTGNCCAACATGATGAAACCCCATCTCTACTA
AAAATACAAAAAATTAGCCGGGCGTGGTAGCGGGCGCCTGTAGTCCCGCTACTCCGGAGG
CTGAGGCAGGAGAATGGCGTGAACCCCGGAGGCGGAACTTGCAGTGAGCCGAGATCGCGC
CACTGCACTTCCACCTGGGCGACAGACCGAGACTCCCTCTTCAAAAAAAAAAAAAAAAAA
AAAATCCACTCTTAAATTGCGGCCGCGGTCCTAGCTTGTTTCCTGAACAGATCCCCGGTG
GGATCCCCTGTAACCCCTCCCCCATGCCCTTTCTTGCACCTGAAAA
>OriGene 3' read for NM_002985 unedited
GCCGCAATCTAAAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTGAAACGAGTCTCGCTCTG
TCGCCCAAGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGT
TCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCTACCAC
GCCCGGCTAATTTTTTGTATTTTTAGTAAAGATGGGGTTTCATCATGTTGGCCAGGCTGG
TCTCGAACTCCTGACCTCAGGGGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTAC
ACGCGTGAGCCACCACGTCCAGCCTGGGGAAGGGTTTTGTAACTGCTGCTGTGTGGTAGA
ATCTGGGCCCTTCAAGGAGCGGGTGGGGTATGATAGTGAGGGGAAGCCTCCCAAGCTAGG
ACAAGAGCAAGCAGAAACAGGCAAATTTGTGTAAGTTCAAGTTCAAGGACTCTCCACCCT
AACTCATCTCCAAAGAGTTGATGTACTCCCGAACCCATTTCTTCTCTGGGTTGGCACACA
CTTGGCGGGTCTTTCGGGTGACAAAGACCACTGCTGGGTTGGAGCACTTGCCACGGGGTA
GAAATACTCCCTGATGTGGGCCCGGGGCACTGGGCCGCCAATGTAAGCAAAACACCAAGG
CGGGGGGTCCCAGGAATATGGGGAAGCAGATGCAGGATCCCCAAAGGCACTTTCATTGAA
GATTACCTTCGAAGGCCGCCCAGGAAAACCTTAGGTTCCCCTGGGAAAAGGCTTCCCAAG
ATCACCTGCCGTGCCCTCTCGCCGAATTGCCGCCCGCCCTATACGAGCCGGTTAACAAAT
CCCGCGGGTCCCAAACGACCCCTCGTTTTTATACCTCCCCCCTCACCCCTCACCCCCTTT
GCGTAATGGGGGGGGTTTTTCACTCTTGAAAGCCGTGTTTGGGGCAAAAATTCCCTGTAC
GCTGGGGTGCAACGCCACCCT
Restriction Sites NotI-NotI     
ACCN NM_002985
Insert Size 850 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002985.2, NP_002976.2
RefSeq Size 1237 bp
RefSeq ORF 276 bp
Locus ID 6352
Cytogenetics 17q12
Domains IL8
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway
Gene Summary 'This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]'
Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform 1.

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