Kallikrein 6 (KLK6) (NM_002774) Human Untagged Clone

CAT#: SC118402

KLK6 (untagged)-Human kallikrein-related peptidase 6 (KLK6), transcript variant A

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLK6
• Synonyms: Bssp; hK6; Klk7; PRSS9; PRSS18; SP59
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118402 sequence for NM_002774 edited (data generated by NextGen Sequencing)
  ATGAAGAAGCTGATGGTGGTGCTGAGTCTGATTGCTGCAGCCTGGGCAGAGGAGCAGAAT
  AAGTTGGTGCATGGCGGACCCTGCGACAAGACATCTCACCCCTACCAAGCTGCCCTCTAC
  ACCTCGGGCCACTTGCTCTGTGGTGGGGTCCTTATCCATCCACTGTGGGTCCTCACAGCT
  GCCCACTGCAAAAAACCGAATCTTCAGGTCTTCCTGGGGAAGCATAACCTTCGGCAAAGG
  GAGAGTTCCCAGGAGCAGAGTTCTGTTGTCCGGGCTGTGATCCACCCTGACTATGATGCC
  GCCAGCCATGACCAGGACATCATGCTGTTGCGCCTGGCACGCCCAGCCAAACTCTCTGAA
  CTCATCCAGCCCCTTCCCCTGGAGAGGGACTGCTCAGCCAACACCACCAGCTGCCACATC
  CTGGGCTGGGGCAAGACAGCAGATGGTGATTTCCCTGACACCATCCAGTGTGCATACATC
  CACCTGGTGTCCCGTGAGGAGTGTGAGCATGCCTACCCTGGCCAGATCACCCAGAACATG
  TTGTGTGCTGGGGATGAGAAGTACGGGAAGGATTCCTGCCAGGGTGATTCTGGGGGTCCG
  CTGGTATGTGGAGACCACCTCCGAGGCCTTGTGTCATGGGGTAACATCCCCTGTGGATCA
  AAGGAGAAGCCAGGAGTCTACACCAACGTCTGCAGATACACGAACTGGATCCAAAAAACC
  ATTCAGGCCAAGTGA
  
  Clone variation with respect to NM_002774.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002774 unedited
  ATACGACTCACTAAGGCGGCCGCGACATTCGCACGAGTGGGCTGGCTGGCTCGCTCTCTC
  CTGGGGACACAGAGGTCGGCAGGCAGCACACAGAGGGACCTACGGGCAGCTGTTCCTTCC
  CCCGACTCAAGAATCCCCGGAGGCCCGGAGGCCTGCAGCAGGAGCGGCCATGAAAAAGCT
  GATGGTGGTGCTGAGTCTGAATGCTGCAGCCTGGGCAGAGGAGCAGAATAAGTTGGTGCA
  TGGCGGACCCTTGCGACAAGACATCTCACCCCTACCAAGCTGCCCTCTACACCTCGGGCC
  ACTTGCTCTGTGGTGGGGTCCTTATCCATCCACTGTGGGTCCTCACAGCTGCCCACTGCA
  AAAAACCGAATCTTCAGGTCTTCCTGGGGAAGCATAACCTTCGGCAAAGGGAGAGTTCCC
  AGGAGCAGAGTTCTGTTGTCCGGGCTGTGATCCACCCTGACTATGATGCCGCCAGCCATG
  ACCAGGACATCATGCTGTTGCGCCTGGCACGCCCAGCCAAACTCTCTGAACTCATCCAGC
  CCCTTCCCCTGGAGAGGGACTGCTCAGCCAACACCACCAGCTGCCACATCCTGNGCTGGG
  GCAAGACAGCAGATGGTGATTTCCCTGACACCATCCAGTGTGCATACATCCACCTGGGTG
  TCCCGTGAGGGAGTGTGAGCATNGCCTACCCTGGCCAGAATACCCAAACATGGTTGTGTG
  CTGGGGATGAAAAAGTACGGNAAGGATTCCTGCCAGGGTGAATCTGGGGGGTCCGCTGGT
  ATGNTGAGAACCACTNNCGAGCCNTGTGTCATGGGGGTACATNCCCTTGTGATCAAGGNA
  GAGCCAGNAGTCTACAACCACGTCTGCAAATCACGAACTGGATCCAAAAAACATCAGGCA
  AANTGACCNTGAATGTGAAATTTACCTNCCGACCTACCACCACTGGNNTGTNCAAAAACG
  NNCTAAACTAAACTA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002774 unedited
  TGGCCCAGGTGCTATTCCATGTATGTCATAGGTGTGAAACCTTAAATCTTTCCAACAGCC
  ACTGCCTTATGGAGACTGTATCATCCTTATCTTCATCTTACAGGTGAGAAAAATCTGCAG
  TGAAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002774
• Insert Size: 1530 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002774.3, NP_002765.1
• RefSeq Size: 1527 bp
• RefSeq ORF: 735 bp
• Locus ID: 5653
• Cytogenetics: 19q13.41
• Domains: Tryp_SPc
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: 'This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]'
  Transcript Variant: This variant (A), also called the classical form, is the most frequently occurring transcript. Variants A and B encode the same isoform (A).