SEPTIN5 (NM_002688) Human Untagged Clone

CAT#: SC118516

41522 (untagged)-Human septin 5 (SEPT5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SEPTIN5
• Synonyms: CDCREL; CDCREL-1; CDCREL1; H5; HCDCREL-1; PNUTL1; SEPT5
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118516 sequence for NM_002688 edited (data generated by NextGen Sequencing)
  ATGAGCACAGGCCTGCGGTACAAGAGCAAGCTGGCGACCCCAGAGGACAAGCAGGACATT
  GACAAGCAGTACGTGGGCTTCGCCACACTGCCCAACCAGGTGCACCGCAAGTCGGTGAAG
  AAAGGCTTTGACTTCACACTCATGGTGGCTGGTGAGTCAGGCCTGGGGAAGTCCACACTG
  GTCCACAGCCTCTTCCTGACAGACTTGTACAAGGACCGGAAGCTGCTCAGTGCTGAGGAG
  CGCATCAGCCAGACGGTAGAGATTCTAAAACACACGGTGGACATTGAGGAGAAGGGAGTC
  AAGCTGAAGCTCACCATCGTGGACACGCCGGGATTCGGGGACGCTGTCAACAACACCGAG
  TGCTGGAAGCCCATCACCGACTATGTGGACCAGCAGTTTGAGCAGTACTTCCGTGATGAG
  AGCGGCCTCAACCGAAAGAACATCCAAGACAACCGAGTGCACTGCTGCCTATACTTCATC
  TCCCCCTTCGGGCATGGGCTGCGGCCAGTGGATGTGGGTTTCATGAAGGCATTGCATGAG
  AAGGTCAACATCGTGCCTCTCATCGCCAAAGCTGACTGTCTTGTCCCCAGTGAGATCCGG
  AAGCTGAAGGAGCGGATCCGGGAGGAGATTGACAAGTTTGGGATCCATGTATACCAGTTC
  CCTGAGTGTGACTCGGACGAGGATGAGGACTTCAAGCAGCAGGACCGGGAACTGAAGGAG
  AGCGCGCCCTTCGCCGTTATAGGCAGCAACACGGTGGTGGAGGCCAAGGGGCAGCGGGTC
  CGGGGCCGACTGTACCCCTGGGGGATCGTGGAGGTGGAGAACCAGGCGCATTGCGACTTC
  GTGAAGCTGCGCAACATGCTCATCCGCACGCATATGCACGACCTCAAGGACGTGACGTGC
  GACGTGCACTACGAGAACTACCGCGCGCACTGCATCCAGCAGATGACCAGCAAACTGACC
  CAGGACAGCCGCATGGAGAGCCCCATCCCGATCCTGCCGCTGCCCACCCCGGACGCCGAG
  ACTGAGAAGCTTATCAGGATGAAGGATGAGGAACTGAGGCGCATGCAGGAGATGCTGCAG
  AGGATGAAGCAGCAGATGCAGGACCAGTGA
  
  Clone variation with respect to NM_002688.5
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002688 unedited
  CGGCCGGCGAATTCGCACGAGGGCGCGGAGGGGCCGCTCACCCCGCAGCCCGGCCTCGGC
  CTCCGCCGCTTGTCGTCGCGCCCCGCCCGCGAGCCCGCCCCGCACGTCCCCCGCCGGCGG
  CCACCATGAGCACAGGCCTGCGGTACAAGAGCAAGCTGGCGACCCCAGAGGACAAGCAGG
  ACATTGACAAGCAGTACGTGGGCTTCGCCACACTGCCCAACCAGGTGCACCGCAAGTCGG
  TGAAGAAAGGCTTTGACTTCACACTCATGGTGGCTGGTGAGTCAGGCCTGGGGAAGTCCA
  CACTGGTCCACAGCCTCTTCCTGACAGACTTGTACAAGGACCGGAAGCTGCTCAGTGCTG
  AGGAGCGCATCAGCCAGACGGTAGAGATTCTAAAACACACGGTGGACATTGAGGAGAAGG
  GAGTCAAGCTGAAGCTCACCATCGTGGACACGCCGGGATTCGGGGACGCTGTCAACAACA
  CCGAGTGCTGGAAGCCCATCACCGACTATGTGGACCAGCAGTTTGAGCAGTACTTCCGTG
  ATGAGAGCGGCCTCAACCGAAAGAACATCCAAGACAACCGAGTGCACTGCTGCCTATACT
  TCATCTCCCCCTTCGGGCATGGGCTGCGGCCAGTGATGTTGGGTTTCATGAAGGCATTGA
  NTGAGAAGGTCAACATCGTGCCTCTCATCGCAAAGCTGACTGTCTTGTCCAAATTGGATC
  CNGAAGCTGANGNANCGGATCCNGNAAGNGAATTGAACAGTTTTTGGGATCCATGTTTTA
  CCCAGTCCCTTGATTGTGACTTCGACCAAGGATGAGGACTTCAAGCAGCAGACCGGGACT
  GGAAGGAAACGCGCCTTTCCCGTATAGCGACACCGGGGGGGGGGAGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002688 unedited
  NATATCTTGCCCGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGCGGTCACCAACATTGTTCTCCTG
  TCACCAAGACAGGACCCGGGTTTTACAACGGAAAAAAACGGGGCCTTGTGGGGGGGGAAG
  GGATCATGCGGGGGGGAACATTGGGGGGCCTAAGCTTAAGATCCCGGCCCACCACAAGGG
  GGCTGGGGAAAAAAGGCCTCCAGCGAGGGCCGGGGACCGCCCCCAAAGTTGCCCGGAGGG
  GGGTTACCCCCCAAGGCCCCGGGGGCCCTCCAAGTCGGGCCGGGCTTTGGAAAAAGGGGG
  TAAACGGTCACAACCCCCCTCCTTGGAACCTTTGGCCTCCTTTTGTTTGGGGGGCTCCCA
  TTTGATTTAACCCAACCCTTCCCCCTAGGGGTTTGGGGATAAAGGAAAACTCGGCCCCCC
  TCGACAAAAAATGGGGGCTCAACACTCCCTGGGGGACCCCCGGGAACAGGCAAAGGAGGG
  CTCCCAAGTCCCTTTTGCACACTGGGGCCGGGAACAAACCCACGATCCTGGGAAACCTTT
  TTTGCCTAACTTTGCCTGCCTGCCAAAACAAGGCCTGGGGGTTTTGGGTGGCTGGGACCC
  CCCCGGGGGCGGGGGGAAAAGGCAAAGGGAGGCCGGATTTCTTGAAATTCCCGCCCCACT
  TTCCCTCCTGTTCCCCCCAGGGCACAAAAGAGGCCACTGGGGGGGGGGGCTTCGGTCCAC
  GGCCCCTTGGAACAAACAACATGACCTGGGAGGGGGGGGGGCCCCAAAATAAAATAAGGG
  ACCTTGGGGGCTGGTGCCCCCGGTCTCCCGGGGGAGAACAAATCCGCGCTGTGTTCCAAG
  GGGCCAAGGGCTCCCCGCAACAACCCGGTTTTCCCCCGCACCACACCGCCCCCCGTTATG
  GGTTCTTCTTTGCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002688
• Insert Size: 2080 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002688.3, NP_002679.2
• RefSeq Size: 2080 bp
• RefSeq ORF: 1110 bp
• Locus ID: 5413
• Cytogenetics: 22q11.21
• Domains: GTP_CDC
• Protein Families: Druggable Genome
• Protein Pathways: Parkinson's disease
• Gene Summary: 'This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]'
  Transcript Variant: This variant (1) encodes the longer isoform (1).