SEPTIN5 (NM_002688) Human Untagged Clone

CAT#: SC320547

41522 (untagged)-Human septin 5 (SEPT5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SEPTIN5
• Synonyms: CDCREL; CDCREL-1; CDCREL1; H5; HCDCREL-1; PNUTL1; SEPT5
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002688.4 CTCACCCCGCAGCCCGGCCTCGGCCTCCGCCGCTTGTCGTCGCGCCCCGCCCGCGAGCCC
  GCCCCGCACGTCCCCCGCCGGCGGCCACCATGAGCACAGGCCTGCGGTACAAGAGCAAGC
  TGGCGACCCCAGAGGACAAGCAGGACATTGACAAGCAGTACGTGGGCTTCGCCACACTGC
  CCAACCAGGTGCACCGCAAGTCGGTGAAGAAAGGCTTTGACTTCACACTCATGGTGGCTG
  GTGAGTCAGGCCTGGGGAAGTCCACACTGGTCCACAGCCTCTTCCTGACAGACTTGTACA
  AGGACCGGAAGCTGCTCAGTGCTGAGGAGCGCATCAGCCAGACGGTAGAGATTCTAAAAC
  ACACGGTGGACATTGAGGAGAAGGGAGTCAAGCTGAAGCTCACCATCGTGGACACGCCGG
  GATTCGGGGACGCTGTCAACAACACCGAGTGCTGGAAGCCCATCACCGACTATGTGGACC
  AGCAGTTTGAGCAGTACTTCCGTGATGAGAGCGGCCTCAACCGAAAGAACATCCAAGACA
  ACCGAGTGCACTGCTGCCTATACTTCATCTCCCCCTTCGGGCATGGGCTGCGGCCAGTGG
  ATGTGGGTTTCATGAAGGCATTGCATGAGAAGGTCAACATCGTGCCTCTCATCGCCAAAG
  CTGACTGTCTTGTCCCCAGTGAGATCCGGAAGCTGAAGGAGCGGATCCGGGAGGAGATTG
  ACAAGTTTGGGATCCATGTATACCAGTTCCCTGAGTGTGACTCGGACGAGGATGAGGACT
  TCAAGCAGCAGGACCGGGAACTGAAGGAGAGCGCGCCCTTCGCCGTTATAGGCAGCAACA
  CGGTGGTGGAGGCCAAGGGGCAGCGGGTCCGGGGCCGACTGTACCCCTGGGGGATCGTGG
  AGGTGGAGAACCAGGCGCATTGCGACTTCGTGAAGCTGCGCAACATGCTCATCCGCACGC
  ATATGCACGACCTCAAGGACGTGACGTGCGACGTGCACTACGAGAACTACCGCGCGCACT
  GCATCCAGCAGATGACCAGCAAACTGACCCAGGACAGCCGCATGGAGAGCCCCATCCCGA
  TCCTGCCGCTGCCCACCCCGGACGCCGAGACTGAGAAGCTTATCAGGATGAAGGATGAGG
  AACTGAGGCGCATGCAGGAGATGCTGCAGAGGATGAAGCAGCAGATGCAGGACCAGTGAC
  GCTCGCCGCGGACACACCGTCCGTCTCCGGGACGCCCTCGCACCCCTGGACACCAGACCG
  GACTGTTCCCGACCCGGAGACGCGGGGCCACAGCCCCCAGCTGACCCTAATTTATTCTCA
  GCACCACCCCCTCCCAGGTCATTGTGTCTGTTTCCGAGGGGCCTGGACCGTAGCCCCCGC
  CCAGCTGGCCCTCTCTGACCTTGGGGGATCAGGAGCGAAGTTGGGCGGGACTTCAGAGAT
  CCGCCTCCCTTGCCCTTCCCCCGCCCCCGGACGGTCACAGCACCCAAACCGCAGGCCCTG
  CTCTGGCAGGCAGGCAAAGCTAGGCAGAAGAGGATTCCCAGGATCCTGGGTCTGTTCCCT
  GCCCCAGTGCTGCAGAACGGACTTGGGAGCCCTCCTTTGCCTGCTCCCGCGGGTCACCCA
  GCGAGTGCTGAGACCCCATTTTCTGTCGAGGCGGGCCGAGTCTTCCCTTATCCCCAGACG
  CCTAGCGGGCAGGGTTGGGCTGAATCAAATGGGAGCCCTCCAGACATAAGGAGGCCAGAG
  GCTGCAAGGAGCGGGGTCGTGACCGCTTACACCCCTTCTCCACAGCCCGGCCCGACCTGG
  AGGGCCCCCGGGGCACTGGGCGGTGAGCCACCTCCTGGCAACTCTCGGTGCCGTCCCCTG
  CCCTCGCTCGAGGCCTCTTCTCCCCAGCACCGCTGTGGTGTGCCGGGATCCTGAGCCTAG
  GCCTCCCGATGTTCCCACCCGCATGATCCCTTCCCGCCACACGATGCTCCGTTTTCTTCC
  GTTGTGAATGCCGCGTCCTGTCCTGGTGACAGGAGAACAATGTTGGTGAACGTCAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_002688
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002688.4, NP_002679.2
• RefSeq Size: 3525 bp
• RefSeq ORF: 1110 bp
• Locus ID: 5413
• Cytogenetics: 22q11.21
• Domains: GTP_CDC
• Protein Families: Druggable Genome
• Protein Pathways: Parkinson's disease
• Gene Summary: 'This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]'
  Transcript Variant: This variant (1) encodes the longer isoform (1).