TrkC (NTRK3) (NM_002530) Human Untagged Clone

CAT#: SC118578

NTRK3 (untagged)-Human neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 2


  "NM_002530" in other vectors (8)

Reconstitution Protocol

USD 1,670.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol NTRK3
Synonyms gp145(trkC); GP145-TrkC; TRKC
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_002530 edited
ATGGATGTCTCTCTTTGCCCAGCCAAGTGTAGTTTCTGGCGGATTTTCTTGCTGGGAAGC
GTCTGGCTGGACTATGTGGGCTCCGTGCTGGCTTGCCCTGCAAATTGTGTCTGCAGCAAG
ACTGAGATCAATTGCCGGCGGCCGGACGATGGGAACCTCTTCCCCCTCCTGGAAGGGCAG
GATTCAGGGAACAGCAATGGGAACGCCAGTATCAACATCACGGACATCTCAAGGAATATC
ACTTCCATACACATAGAGAACTGGCGCAGTCTTCACACGCTCAACGCCGTGGACATGGAG
CTCTACACCGGACTTCAAAAGCTGACCATCAAGAACTCAGGACTTCGGAGCATTCAGCCC
AGAGCCTTTGCCAAGAACCCCCATTTGCGTTATATAAACCTGTCAAGTAACCGGCTCACC
ACACTCTCGTGGCAGCTCTTCCAGACGCTGAGTCTTCGGGAATTGCAGTTGGAGCAGAAC
TTTTTCAACTGCAGCTGTGACATCCGCTGGATGCAGCTCTGGCAGGAGCAGGGGGAGGCC
AAGCTCAACAGCCAGAACCTCTACTGCATCAACGCTGATGGCTCCCAGCTTCCTCTCTTC
CGCATGAACATCAGTCAGTGTGACCTTCCTGAGATCAGCGTGAGCCACGTCAACCTGACC
GTACGAGAGGGTGACAATGCTGTTATCACTTGCAATGGCTCTGGATCACCCCTTCCTGAT
GTGGACTGGATAGTCACTGGGCTGCAGTCCATCAACACTCACCAGACCAATCTGAACTGG
ACCAATGTTCATGCCATCAACTTGACGCTGGTGAATGTGACGAGTGAGGACAATGGCTTC
ACCCTGACGTGCATTGCAGAGAACGTGGTGGGCATGAGCAATGCCAGTGTTGCCCTCACT
GTCTACTATCCCCCACGTGTGGTGAGCCTGGAGGAGCCTGAGCTGCGCCTGGAGCACTGC
ATCGAGTTTGTGGTGCGTGGCAACCCCCCACCAACGCTGCACTGGCTGCACAATGGGCAG
CCTCTGCGGGAGTCCAAGATCATCCATGTGGAATACTACCAAGAGGGAGAGATTTCCGAG
GGCTGCCTGCTCTTCAACAAGCCCACCCACTACAACAATGGCAACTATACCCTCATTGCC
AAAAACCCACTGGGCACAGCCAACCAGACCATCAATGGCCACTTCCTCAAGGAGCCCTTT
CCAGAGAGCACGGATAACTTTATCTTGTTTGACGAAGTGAGTCCCACACCTCCTATCACT
GTGACCCACAAACCAGAAGAAGACACTTTTGGGGTATCCATAGCAGTTGGACTTGCTGCT
TTTGCCTGTGTCCTGTTGGTGGTTCTCTTCGTCATGATCAACAAATATGGTCGACGGTCC
AAATTTGGAATGAAGGGTCCCGTGGCTGTCATCAGTGGTGAGGAGGACTCAGCCAGCCCA
CTGCACCACATCAACCACGGCATCACCACGCCCTCGTCACTGGATGCCGGGCCCGACACT
GTGGTCATTGGCATGACTCGCATCCCTGTCATTGAGAACCCCCAGTACTTCCGTCAGGGA
CACAACTGCCACAAGCCGGACACGTATGTGCAGCACATTAAGAGGAGAGACATCGTGCTG
AAGCGAGAACTGGGTGAGGGAGCCTTTGGAAAGGTCTTCCTGGCCGAGTGCTACAACCTC
AGCCCGACCAAGGACAAGATGCTTGTGGCTGTGAAGGCCCTGAAGGATCCCACCCTGGCT
GCCCGGAAGGATTTCCAGAGGGAGGCCGAGCTGCTCACCAACCTGCAGCATGAGCACATT
GTCAAGTTCTATGGAGTGTGCGGCGATGGGGACCCCCTCATCATGGTCTTTGAATACATG
AAGCATGGAGACCTGAATAAGTTCCTCAGGGCCCATGGGCCAGATGCAATGATCCTTGTG
GATGGACAGCCACGCCAGGCCAAGGGTGAGCTGGGGCTCTCCCAAATGCTCCACATTGCC
AGTCAGATCGCCTCGGGTATGGTGTACCTGGCCTCCCAGCACTTTGTGCACCGAGACCTG
GCCACCAGGAACTGCCTGGTTGGAGCGAATCTGCTAGTGAAGATTGGGGACTTCGGCATG
TCCAGAGATGTCTACAGCACGGATTATTACAGGGTGGGAGGACACACCATGCTCCCCATT
CGCTGGATGCCTCCTGAAAGCATCATGTACCGGAAGTTCACTACAGAGAGTGATGTATGG
AGCTTCGGGGTGATCCTCTGGGAGATCTTCACCTATGGAAAGCAGCCATGGTTCCAACTC
TCAAACACGGAGGTCATTGAGTGCATTACCCAAGGTCGTGTTTTGGAGCGGCCCCGAGTC
TGCCCCAAAGAGGTGTACGATGTCATGCTGGGGTGCTGGCAGAGGGAACCACAGCAGCGG
TTGAACATCAAGGAGATCTACAAAATCCTCCATGCTTTGGGGAAGGCCACCCCAATCTAC
CTGGACATTCTTGGCTAG
>OriGene 5' read for NM_002530 unedited
CTGTTCACGATGTTGAAAACTCGNACTNCACTNTGAGGGNCGGACCGCCNAATCGGCACG
AGGCTCCTCTTTTTTAGAAGCAGCGATCGGAGAGGATGTCTCTCTTTGCCCAGCCAAGTG
TAGTTTCTGGCGGATTTTCTTGCTGGGAAGCGTCTGGCTGGACTATGTGGGCTCCGTGCT
GGCTTGCCCTGCAAATTGTGTCTGCAGCAAGACTGAGATCAATTGCCGGCGGCCGGACGA
TGGGAACCTCTTCCCCCTCCTGGAAGGGCAGGATTCAGGGAACAGCAATGGGAACGCCAG
TATCAACATCACGGACATCTCAAGGAATATCACTTCCATACACATAGAGAACTGGCGCAG
TCTTCACACGCTCAACGCCGTGGACATGGAGCTCTACACCGGACTTCAAAAGCTGACCAT
CAAGAACTCAGGACTTCGGAGCATTCAGCCCAGAGCCTTTGCCAAGAACCCCCATTTGCG
TTATATAAACCTGTCAAGTAACCGGCTCACCACACTCTCGTGGCAGCTCTTCCAGACGCT
GAGTCTTCGGGAATTGCAGTTGGAGCAGAACTTTTTCAACTGCAGCTGTGACATCCGCTG
GATGCAGCTCTGGCAGGAGCAGGGGGAGGCCAAGCTCAACAGCCAGAACCTCTACTGCAT
CAACGCTGATGGCTCCCAGCTTCCTCTCTTCCGCATGAACATCAGTCAGTGTGACCTTCC
TGAGATCAGCGTGAGCCACGTTAACCTGACCGTACGAGAGGGTGACCATGCTGTTATCAC
TTGCAATGGCTCCTGGACCACCCCTTCCTGATGTGGACTGAATAGTTACTGGGCTGCAGT
CCATTCACACTCACCAGGACAATCTGAAACTGGACCATGTTCATGCCCATCAACTGACGC
TTGTGCATGTGACCAGTGAAGACACTGCCTTCACCTGT
>OriGene 3' read for NM_002530 unedited
CTTTCCAGGGCCAGGNATAGCACTGGGGAGGGGTCACAGGNATGCCACCCGGGATCTGTT
CAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCA
GTGTTGTATGTGTAGCAGGCACTTGAGTTTATATGAAGATGTTCGCTTCAGTCAAGGATG
GAAGGAGTTGTGAGGTGGAAGGGAGATGTGAGGCAGGGAGAGAGGAGGCAACAGAGTATG
AATTCATGACCACCAGCCACCACTAGCCAAGAATGTCCAGGTAGATTGGGGTGGCCTTCC
CCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCTCT
GCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAA
CACGACCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCT
TTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCACTCTCTGTAG
TGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTC
CTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCT
TCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCCAGTCTCGGTGCACAAAGT
GCTGGGAGGCCAGGTACACCATACCCGNAGCGATCTGACTGGNCATGTGGAGCATTTGGG
AGAGCCCCAGCTCACCCTTGGCCTGCGGTGGCTGTCCATCCACAAGATCATTGCATCTGG
CCATGGGCCCTGANNGACTTATCANGTCTCATGCTTCATGANCAAGACATGAGAGAGGGG
GCCCCATCGCCNCACTCATAGACTTGCATGGCTATGCTNCAGTTGGGAGCACTCGGCTCT
TTGAATCTTCGCACCGGGGTGAATCT
Restriction Sites NotI-NotI     
ACCN NM_002530
Insert Size 2800 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002530.2, NP_002521.2
RefSeq Size 2818 bp
RefSeq ORF 2478 bp
Locus ID 4916
Cytogenetics 15q25.3
Domains LRRNT, LRRCT, pkinase, TyrKc, LRR, S_TKc, ig, IG
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Neurotrophin signaling pathway
Gene Summary 'This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]'
Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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