SH2D1A (NM_002351) Human Untagged Clone

CAT#: SC118690

SH2D1A (untagged)-Human SH2 domain containing 1A (SH2D1A), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SH2D1A
• Synonyms: DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002351 edited
  ATGGACGCAGTGGCTGTGTATCATGGCAAAATCAGCAGGGAAACCGGCGAGAAGCTCCTG
  CTTGCCACTGGGCTGGATGGCAGCTATTTGCTGAGGGACAGCGAGAGCGTGCCAGGCGTG
  TACTGCCTATGTGTGCTGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAA
  ACAGGTTCTTGGAGTGCTGAGACAGCACCTGGGGTACATAAAAGATATTTCCGGAAAATA
  AAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTGCAGTAT
  CCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATAAGAGAAGAT
  CCTGATGTCTGCCTGAAAGCCCCATGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002351 unedited
  GGTCAAAATTTGTAAACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGGAGTCAGG
  TGGTTGACTTGTGCCTGGCTGCAGTAGCAGCGGCATCTCCCTTGCACAGTTCTCCTCCTC
  GGCCTGCCCAAGAGTCCACCAGGCCATGGACGCAGTGGCTGTGTATCATGGCAAAATCAG
  CAGGGAAACCGGCGAGAAGCTCCTGCTTGCCACTGGGCTGGATGGCAGCTATTTGCTGAG
  GGACAGCGAGAGCGTGCCAGGCGTGTACTGCCTATGTGTGCTGTATCACGGTTACATTTA
  TACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACAGCACCTGGGGT
  ACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCA
  AGGCATTGTAATACCTCTGCAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACA
  AGGTACTACAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGAAGAANAAT
  AAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAG
  ATAATACAGTTCGGTGAGCTACAAATGCATTTCTAAAGCCATTGTAGTCCTGTAATGGAA
  GCATCTAGCATGTCGTCAAAGCTGANATGGACTTTTGTACATAGTGAGGAGCTTNTGAAC
  GAGGATTGGGAAAAAGNTATTCCCCGTAGTATTTTCAGTTATTATATTTACAAATGGGAA
  ACAAANGGATNATGAATACTTTATAAAGGATTAAATGTCATTTCTGNNCCAATATAATAA
  AAATATCCTCCATTTTTTGTGAAAAGCTTCATTTTTAGTGAAATATATTTTATAGCTACT
  AATTTTAAAANTGTCTGCNNTGATGATGGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002351 unedited
  NTTCTACTTGNACGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTAAAGCTT
  TCAAACACTTTATTTAAATGTGAAAGACTTGATGATTCAAAAAAAGCTTTTTTTCAAAAA
  AAGGCTCTTGGAAGTGAACATGCAAACATAATTCATATGTTTAGGATTATTCCAGAATGA
  ACACATTATAGAGTTAAAATTAGTTACGCCTATTACAATTTAAACTCAAGCCATATAATT
  AAAAATTATTAAACCTATGCAACTTATTATGAAAGTAGGATTTTTAAATTCCTTTACAAG
  TTCATGTGATGCTTTTACCTCAAGAAATGGTAAACCACCCATAATGCATTACTCAGGCCA
  CACTCCACTTTTGTACTCCCACGGCATCCATATTAAATGCTCAGAAATCAGGTCTTGCCA
  GTACATGGAGAATAGCTCTGTCTCTCAGCAGTTCACTAATTAAAACCAAGTTCACCAACA
  CCCATACACAATCCAGAATTCCCAGTTATTATTTTACAGTGAAGCTTAGCCTTTTCATAT
  GGCCCATGGACCAGAGTATTTGCACTGACCTATCTATCTGCCTCTAAAGACCAGATCTAC
  CTACACACGGGGAACCTCGCTTATCATGTACTTATCAACTTTCATTGGTATTTTTTCCTT
  GGCTTTTATTGGTATTNTCTTTCACTGGCTTTTATCGNTATTTTCTTTCACTGTCTTTTA
  TCGNTATTGTTTTCTCGTCCACAAGACAGTGAACTGAGAGCAGGGACCAGGTGTTTTTAC
  TTCTATGCCCTCAGCGCCCTATTATGTNTGNTGAGTGAATGAANTCTGTGAGCCCTGTNG
  CAAAGTGACATANTATCAATCACAAAATCACCAAAATATTAATGTGAGAAGAAAATGCCG
  CATAAAATCTGTATCTCGTGGTAGTTTCAATCACTTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002351
• Insert Size: 2390 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002351.1, NP_002342.1
• RefSeq Size: 2530 bp
• RefSeq ORF: 387 bp
• Locus ID: 4068
• Cytogenetics: Xq25
• Domains: SH2
• Protein Families: Druggable Genome
• Protein Pathways: Natural killer cell mediated cytotoxicity
• Gene Summary: 'This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).