MAFK (NM_002360) Human Untagged Clone

CAT#: SC118696

MAFK (untagged)-Human v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) (MAFK)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MAFK
• Synonyms: NFE2U; P18
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002360 edited
  ATGACGACTAATCCCAAACCGAATAAGGCATTAAAGGTCAAGAAGGAGGCGGGCGAGAAC
  GCCCCGGTGCTCAGCGATGATGAGCTGGTGTCCATGTCGGTGCGGGAGCTGAACCAGCAC
  CTGCGGGGTCTCACCAAGGAGGAGGTGACCCGCCTGAAGCAGCGTCGGCGCACACTCAAG
  AACCGCGGCTACGCGGCCAGCTGCCGCATCAAGCGGGTGACGCAGAAGGAGGAGCTGGAG
  CGGCAGCGCGTGGAGCTGCAGCAGGAGGTGGAGAAGCTGGCGCGTGAGAACAGCAGCATG
  CGGCTGGAGCTGGACGCCCTGCGCTCCAAGTACGAGGCGCTGCAGACCTTCGCGCGCACC
  GTGGCCCGGGGACCTGTGGCGCCCTCCAAGGTGGCCACCACCAGCGTCATCACCATCGTC
  AAGTCCACCGAGCTCTCCTCCACCTCCGTGCCCTTCTCGGCTGCATCCTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002360 unedited
  NNNNGGTTTAAATTTGTATACGACTCACTATAGGGCGGCCGCGNAATTCGCACCAGGGGG
  CACCTTGTGCTGTGCAGGTGCAGACGTCTTCTCTGACCTCAGGGAGAGTCAGAACAGGAA
  GCAGCCACTGCCGGCGCCTGCTGGTCACCCCACAGTGCCGGCGGCTGCAGCCCAGCTACG
  AGTTCCAGGGAGCTCTGTCCTGGTGACCGTGCCCGGGTTATGACGACTAATCCCAAACCG
  AATAAGGCATTAAAGGTCAAGAAGGAGGCGGGCGAGAACGCCCCGGTGCTCAGCGATGAT
  GAGCTGGTGTCCATGTCGGTGCGGGAGCTGAACCAGCACCTGCGGGGTCTCACCAAGGAG
  GAGGTGACCCGCCTGAAGCAGCGTCGGCGCACACTCAAGAACCGCGGCTACGCGGCCAGC
  TGCCGCATCAAGCGGGTGACGCANAAGGAGGAGCTGGAGCGGCAGCGCGTGGAGCTGCAG
  CAGGAGGTGGAGAAGCTGGCGCGTGAGAACAGCAGCATGCGGCTGGAGCTGGACGCCCTG
  CGCTCCAAGTACGAGGCGCTGCAGACCTTCGCGCGCACCGTGGCCCGGGGACCTGTGGCG
  CCCTCCAAGGTGGCCACCACCAGCGTCATCACCATCGTCAAGTCCACCGAGCTCTCCTCC
  ACCTCCGTGCCCTTCTCGGCTGCATCCTANTGCCGGCNCGGGGCGGNGGGTGGCCGGCGG
  CGGGCCGCGGTCATGCGGGTGGGGGCACACCCCTCGTACCTGTCACTGGGATGCAGACTC
  TCGACATCCGAGTCCAAGCGCCAGGCCCCTCGGGCGCAGGCAGCTCACACCAAGAAGAGA
  CTGTATTGCAGGGTGAAGAGTGGGCTCCCCGTGCCCCANAGCTGCACGCCCGGTCACAGA
  ACACTTACGCCCGNCACCTGTTCCCGCAGGAGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002360
• ORF Size: 471 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_002360.2, NP_002351.1
• RefSeq Size: 1581
• RefSeq ORF: 471
• Locus ID: 7975
• Domains: bZIP_Maf, BRLZ
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites. [supplied by OMIM, Nov 2008]