KCNA3 (NM_002232) Human Untagged Clone

CAT#: SC118765

KCNA3 (untagged)-Human potassium voltage-gated channel, shaker-related subfamily, member 3 (KCNA3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KCNA3
• Synonyms: HGK5; HLK3; HPCN3; HUKIII; KV1.3; MK3; PCN3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002232 edited
  ATGGACGAGCGCCTCAGCCTTCTGCGCTCGCCGCCGCCGCCCTCAGCCCGCCACCGCGCC
  CACCCTCCTCAGCGCCCAGCGAGCAGCGGCGGTGCCCACACGCTGGTGAACCACGGCTAC
  GCGGAGCCCGCCGCAGGCCGCGAGCTGCCGCCCGACATGACCGTGGTGCCCGGGGACCAC
  CTGCTGGAGCCGGAGGTGGCCGATGGTGGAGGGGCCCCGCCTCAAGGCGGCTGTGGCGGC
  GGCGGCTGCGACCGCTACGAGCCGCTGCCGCCCTCACTGCCGGCCGCGGGCGAGCAGGAC
  TGCTGCGGGGAGCGCGTGGTCATCAACATCTCCGGGCTGCGCTTCGAGACGCAGCTGAAG
  ACCCTTTGCCAGTTCCCCGAGACGCTGCTGGGCGACCCCAAGCGGCGCATGAGGTACTTC
  GACCCGCTCCGCAACGAGTACTTCTTCGACCGCAACCGGCCCAGCTTCGACGCCATCCTC
  TACTACTATCAGTCCGGGGGCCGCATCCGCCGGCCGGTCAACGTGCCCATCGACATTTTC
  TCCGAGGAGATCCGCTTCTACCAGCTGGGCGAGGAGGCCATGGAGAAGTTCCGCGAGGAC
  GAGGGCTTCCTGCGGGAGGAGGAGCGGCCCTTGCCCCGCCGCGACTTCCAGCGCCAGGTG
  TGGCTGCTCTTCGAGTACCCCGAGAGCTCCGGGCCGGCCCGGGGCATCGCCATCGTGTCC
  GTGCTGGTCATCCTCATCTCCATTGTCATCTTCTGCCTGGAGACGCTGCCGGAGTTCCGC
  GACGAGAAGGACTACCCCGCCTCGACGTCGCAGGACTCATTCGAAGCAGCCGGCAACAGC
  ACGTCGGGGTCCCGCGCAGGAGCCTCCAGCTTCTCCGATCCCTTCTTCGTGGTGGAGACG
  CTGTGCATCATCTGGTTCTCCTTCGAACTGCTGGTGCGGTTCTTCGCTTGTCCTAGCAAA
  GCCACCTTCTCGCGAAACATCATGAACCTGATCGACATTGTGGCCATCATTCCTTATTTT
  ATCACTCTGGGTACCGAGCTGGCCGAACGACAGGGCAATGGACAGCAGGCCATGTCTCTG
  GCCATCCTGAGGGTCATCCGCCTGGTAAGGGTCTTCCGCATCTTCAAGCTGTCGCGCCAC
  TCCAAGGGGCTGCAGATCCTCGGGCAAACGCTGAAGGCGTCCATGCGGGAGCTGGGATTG
  CTCATCTTCTTCCTCTTTATTGGGGTCATCCTTTTCTCCAGCGCGGTCTACTTTGCCGAG
  GCAGACGACCCCACTTCAGGTTTCAGCAGCATCCCGGATGCCTTCTGGTGGGCAGTGGTA
  ACCATGACAACAGTGGGTTACGGCGATATGCACCCAGTGACCATAGGGGGCAAGATTGTG
  GGATCTCTCTGTGCCATCGCCGGTGTCTTGACCATCGCATTGCCAGTTCCCGTGATTGTT
  TCCAACTTCAATTACTTCTACCACCGGGAGACAGAAGGGGAAGAGCAATCCCAGTACATG
  CACGTGGGAAGTTGCCAGCACCTCTCCTCTTCAGCCGAGGAGCTCCGAAAAGCAAGGAGT
  AACTCGACTCTGAGTAAGTCGGAGTATATGGTGATCGAAGAGGGGGGTATGAACCATAGC
  GCTTTCCCCCAGACCCCTTTCAAAACGGGCAATTCCACTGCCACCTGCACCACGAACAAT
  AATCCCAACTCTTGTGTCAACATCAAAAAGATATTCACCGATGTTTAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002232 unedited
  NGTCAAAATTTGTATACGACTCCTATAGGCGGCCGCGNAATTCGCACGAGNAGAGCATCG
  CGGCTTTGGCTGCAACAGGCGGTGGGCTCGGCTCGGGGGCGGAGGCGGCGAAAGGGCGGG
  GAGCGCGAGGAGGAGCGACCTGGCCTCACCGCTGCCGCCTCTTCCCCGCCGCATGGACGA
  GCGCCTCAGCCTTCTGCGCTCGCCGCCGCCGCCCTCAGCCCGCCACCGCGCCCACCCTCC
  TCAGCGCCCAGCGAGCAGCGGCGGTGCCCACACGCTGGTGAACCACGGCTACGCGGAGCC
  CGCCGCAGGCCGCGAGCTGCCGCCCGACATGACCGTGGTGCCCGGGGACCACCTGCTGGA
  GCCGGAGGTGGCCGATGGTGGAGGGGCCCCGCCTCAAGGCGGCTGTGGCGGCGGCGGCTG
  CGACCGCTACGAGCCGCTGCCGCCCTCACTGCCGGCCGCGGGCGAGCAGGACTGCTGCGG
  GGAGCGCGTGGTCATCAACATCTCCGGGCTGCGCTTCGAGACGCAGCTGAAGACCCTTTG
  CCAGTTCCCCGAGACGCTGCTGGGCGACCCCAAGCGGCGCATGAGGTACTTCGACCCGCT
  CCGCAACGAGTACTTCTTCGACCGCAACCGGCCCAGCTTCGACGCCATCCTCTACACTAT
  CAGTCNCGGGGGCCGCATCCGCCGGCCGGTCAACGTGCCCATCGACATTTTCTCGNAGGA
  GATCCGCTTCTACCAGCTGGGCGAGGAGGCCTTGGNANAAAGTCCGCGAGGACGAGGGCT
  TNNCTGCGGNAGGGAGGNAGCGGCCCTTGCCCCGNCGCGACTTCCACGCCCAGGGGTGGC
  TGCTCTTCGAGACCCGAGGACTCCCGGCCCGGCCCGGGCATGNCTANNGGGNCCCGGGCT
  GGGCATCTCATCTCCATTGCATCTCTGGCTGAACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002232 unedited
  AAAAAAGAGGTTGNCAGNCTGTCTTTATACTCTTCTTTGGGCACGTGTAGACTTCACTTA
  TTTATATGTAAATGGGCTAATCTATGTATGAGAGCCTTTGGTACAAAACACACCTTCACA
  AATAAAGTTGCACATAACCCAGAACATGGAATATAACACGACTATATCTCATGATTAAAC
  ACAGTCCACTACTTAATTGAAAAAAAAAAACAAANACAGTAATAGTTGGCTTGCTAGAAA
  ACAAATTTANGCTTTTCTTTCTGCAGCACTGATTATAGNTTTGGGATGATTCGATTTCAT
  CAAAATGTCAAAAGGTTGCAATGATACCTTAAAATTTTAACATTCTTAATTCTTTGAAGA
  AAAGGCTTTAATTTGCCCGCCTTTTGAAAGGAAATCCTCCAATTTAAGAGTGGTCCCTTT
  ATTAAAGGCTTTTGTTAGAGCATTTTTTTTAAGGGAACCGGGATAAAAAAATTTGGGGGG
  GGAAGGGGGACCCTGCCCCCCAAGAGGAATAACCGGGGCCCCGGTTTTTTTGCGCCCCGC
  GGTTTTAAAAGGGGGGCCTTCTTTTGGGGGGGGGGGCGGTTTTAACATTTTTTTTATGGG
  GGGGGGCTTTGTGGGGTCTTTTTTTTTCAAAAAGAGGGTCTTAATAATTTTTTAAAATTT
  TGGGGGGGGGGGGGTTTTTTTTTTTTTTTTTTTTTGGGGGGGGGGGGTTTCTCTTTTTTT
  TCCCCCGCGGGCGGGGGGGGGGGAGAGGGGGTCCCCCCCCCTTTTTTTTTTTTTTTTTTT
  TTTTTTCCCCCCCCTCTCTATTAGAGAAGAAAAACAAAAAGGGGGGTGTCCAAAACAAAA
  AAAGAAGGACCCCCCCCCCCCCCCTCCTTTATTAGGGGGGGGGGGGCCAAAACCTCAAAA
  AAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002232
• ORF Size: 1572 bp
• Insert Size: 4200
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_002232.3.

Reference Data

• RefSeq: NM_002232.2, NP_002223.2
• RefSeq Size: 3303
• RefSeq ORF: 1572
• Locus ID: 3738
• Domains: BTB, K_tetra, ion_trans
• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane
• Gene Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) encodes the functional protein.